Patents by Inventor David C. Flyer

David C. Flyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified rapid expansion methods(“modified-REM”) for in vitro propagation of T lymphocytes
    Patent number: 6890753
    Abstract: The present invention provides a modified rapid expansion method (termed “low-PBMC-REM” or “modified-REM”), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes, without using the large excesses of peripheral blood mononuclear cells (PBMC) or EBV-transformed lymphoblastoid cells (LCL) characteristic of high-PBMC-REM. Clonal expansions of greater than 500-fold can be achieved within a single stimulation cycle of about 8-14 days.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: May 10, 2005
    Inventors: David C. Flyer, Kim W. Clary
  • Modified rapid expansion methods ("modified-REM") for in vitro propagation of T lymphocytes
    Publication number: 20020197716
    Abstract: The present invention provides a modified rapid expansion method (termed “low-PBMC-REM” or “modified-REM”), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes, without using the large excesses of peripheral blood mononuclear cells (PBMC) or EBV-transformed lymphoblastoid cells (LCL) characteristic of high-PBMC-REM. Clonal expansions of greater than 500-fold can be achieved within a single stimulation cycle of about 8-14 days.
    Type: Application
    Filed: September 17, 2001
    Publication date: December 26, 2002
    Inventors: David C. Flyer, Kim W. Clary
  • Modified rapid expansion methods (“modified-REM”) for in vitro propagation of T lymphocytes
    Patent number: 6316257
    Abstract: The present invention provides a modified rapid expansion method (termed “low-PBMC-REM” or “modified-REM”), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes, without using the large excesses of peripheral blood mononuclear cells (PBMC) or EBV-transformed lymphoblastoid cells (LCL) characteristic of high-PBMC-REM. Clonal expansions of greater than 500-fold can be achieved within a single stimulation cycle of about 8-14 days.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: November 13, 2001
    Assignee: Targeted Genetics Corporation
    Inventors: David C. Flyer, Kim W. Clary