Patents by Inventor David C. Gale

David C. Gale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Implantable medical devices fabricated from polymer blends with star-block copolymers
    Patent number: 8262723
    Abstract: Implantable medical devices are fabricated from polymer blends with star-block copolymers. The polymer blends include a biodegradable matrix polymer blended with a biodegradable star-block copolymer. The copolymer has at least three arms and the arms include inner segments and outer segments. The inner segments form a discrete phase within a continuous phase, the continuous phase including the matrix polymer and the outer segments. The segments can include units having acidic degradation products that enhance the degradation rate of the blend.
    Type: Grant
    Filed: April 9, 2007
    Date of Patent: September 11, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Yunbing Wang, David C. Gale, Bin Huang
  • METHOD OF FABRICATING AN IMPLANTABLE MEDICAL DEVICE WITH BIAXIALLY ORIENTED POLYMERS
    Publication number: 20120217672
    Abstract: Methods and systems for manufacturing an implantable medical device, such as a stent, from a tube with desirable mechanical properties, such as improved circumferential strength and rigidity, are described herein. Improved circumferential strength and rigidity may be obtained by inducing molecular orientation in materials for use in manufacturing an implantable medical device. Methods of inducing circumferential molecular orientation by inducing circumferential flow in a molten polymer are disclosed.
    Type: Application
    Filed: May 3, 2012
    Publication date: August 30, 2012
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Bin Huang, Stephen Schaible, Richard Kaufman, Jim Kennedy, David C. Gale, Suresh Amin, John Guardiano
  • Method of forming a stent pattern on a tube
    Patent number: 8241554
    Abstract: Methods of fabricating an implantable medical device from a tube or a sheet in an expanded or stretched state, respectively, are disclosed herein. The implantable medical device may be an endoprosthesis such as a stent. In one embodiment, the method may include radially expanding a tube about a cylindrical axis of the tube from a first diameter to a second diameter. The method may further include forming a pattern on at least a portion of the expanded tube. Additional embodiments may include forming a stent pattern on a stretched sheet from which a stent may be formed. In addition, a stent pattern may be formed on a tube that is formed from a stretched sheet.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: August 14, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Anthony J. Abbate, David C. Gale, Klaus Kleine, Svava Maria Atladottir
  • METHOD AND APPARATUS FOR DELIVERING AN AGENT TO A KIDNEY
    Publication number: 20120203174
    Abstract: A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
    Type: Application
    Filed: April 13, 2012
    Publication date: August 9, 2012
    Applicant: Abbot Cardiovascular Systems Inc.
    Inventors: Paul M. Consigny, Fozan O. El-Nounou, David C. Gale, Pamela A. Kramer-Brown
  • METHOD AND APPARATUS FOR DELIVERING AN AGENT TO A KIDNEY
    Publication number: 20120203202
    Abstract: A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
    Type: Application
    Filed: April 13, 2012
    Publication date: August 9, 2012
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Paul M. Consigny, Fozan O. El-Nounou, David C. Gale, Pamela A. Kramer-Brown
  • Method and apparatus for delivering an agent to a kidney
    Patent number: 8216209
    Abstract: A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: July 10, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Paul M. Consigny, Fozan O. El-Nounou, David C. Gale, Pamela A. Kramer-Brown
  • Method of fabricating an implantable medical device with biaxially oriented polymers
    Patent number: 8192678
    Abstract: Methods and systems for manufacturing an implantable medical device, such as a stent, from a tube with desirable mechanical properties, such as improved circumferential strength and rigidity, are described herein. Improved circumferential strength and rigidity may be obtained by inducing molecular orientation in materials for use in manufacturing an implantable medical device. Some embodiments may include inducing molecular orientation by expansion of a molten annular polymer film. Other embodiments may include inducing circumferential molecular orientation by inducing circumferential flow in a molten polymer. In certain embodiments, circumferential orientation may be induced by expansion of a polymer tube. Further embodiments may include manufacturing an implantable medical device from a biaxially oriented planar polymer film.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: June 5, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Bin Huang, Stephen Schalble, David C. Gale
  • Methods for fabricating polymer-bioceramic composite implantable medical devices
    Patent number: 8192665
    Abstract: Methods relating to polymer-bioceramic composite implantable medical devices are disclosed.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: June 5, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Bin Huang, David C. Gale
  • RGD PEPTIDE ATTACHED TO BIOABSORBABLE STENTS
    Publication number: 20120135131
    Abstract: Provided herein is a method of forming medical device that includes RGD attached to the device via a spacer compound. The method comprises providing a spacer compound comprising a hydrophobic moiety and a hydrophilic moiety, grafting or embedding the spacer compound to the surface layer of the polymer to cause the hydrophobic moiety to be grafted to or embedded within the surface layer of polymer, and attaching a chemo-attractant to the hydrophilic moiety.
    Type: Application
    Filed: February 3, 2012
    Publication date: May 31, 2012
    Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.
    Inventors: David C. Gale, Bin Huang, Kleine Klaus
  • Polymer and metal composite implantable medical devices
    Patent number: 8172897
    Abstract: A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device. A further aspect of the invention includes device and a method of manufacturing the device that includes a mixture of a biodegradable polymer and bioerodable metallic particles. The mixture may be used to fabricate an implantable medical device or to coat an implantable medical device. In some embodiments, the metallic particles are metallic nanoparticles.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: May 8, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: David C. Gale, Bin Huang, John M Capek, John Y. Yan, Houdin Dehnad
  • Method of Fabricating Polymer blend-bioceramic composite implantable medical devices
    Patent number: 8119705
    Abstract: Methods and devices relating to polymer blend/bioceramic composite implantable medical devices are disclosed.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: February 21, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Yunbing Wang, David C. Gale
  • RGD peptide attached to bioabsorbable stents
    Patent number: 8118863
    Abstract: Provided herein is a method of forming medical device that includes RGD attached to the device via a spacer compound. The method comprises providing a spacer compound comprising a hydrophobic moiety and a hydrophilic moiety, grafting or embedding the spacer compound to the surface layer of the polymer to cause the hydrophobic moiety to be grafted to or embedded within the surface layer of polymer, and attaching a chemo-attractant to the hydrophilic moiety.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: February 21, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: David C. Gale, Bin Huang, Kleine Klaus
  • STENT HAVING CIRCUMFERENTIALLY DEFORMABLE STENTS
    Publication number: 20120041543
    Abstract: Disclosed is a method of treating a bodily lumen with a stent, the method comprising: disposing a stent within a bodily lumen, the stent comprising a plurality of deformable struts that are substantially circumferentially aligned and are configured to selectively deform in a circumferential direction in localized regions in the struts upon application of an outward radial force; and expanding the stent by applying the outward radial force, wherein the outward radial force causes selective deformation of the deformable struts in a localized region in the struts.
    Type: Application
    Filed: October 25, 2011
    Publication date: February 16, 2012
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: BIN HUANG, DAVID C. GALE
  • RGD peptide attached to bioabsorbable stents
    Patent number: 8114150
    Abstract: Provided herein is a medical device that includes RGD attached to the device via a spacer compound.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: February 14, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: David C. Gale, Bin Huang, Kleine Klaus
  • METHODS FOR IMPROVED STENT RETENTION
    Publication number: 20120024474
    Abstract: Methods for improved stent retention on an expandable member during delivery are disclosed. Methods include fabricating delivery systems including a retention layer over the stent, the expandable member, or both for improving retention of the stent on the expandable member during delivery.
    Type: Application
    Filed: October 6, 2011
    Publication date: February 2, 2012
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Bin Huang, Daniel Castro, David C. Gale, Yunbing Wang
  • METHODS FOR IMPROVED STENT RETENTION
    Publication number: 20120024460
    Abstract: Methods for improved stent retention on an expandable member during delivery are disclosed. Methods include fabricating delivery systems including a degradable or water soluble sheath over the stent, the expandable member, or both for improving retention of the stent on the expandable member during delivery.
    Type: Application
    Filed: October 6, 2011
    Publication date: February 2, 2012
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Bin Huang, Daniel Castro, David C. Gale, Yunbing Wang
  • ASSEMBLY FOR MAKING A POLYMERIC MEDICAL DEVICE
    Publication number: 20120013061
    Abstract: A polymeric tube is positioned on a polymeric mandrel and then laser cut to form an implantable medical device, such as a stent. The assembly and method reduces contamination of the inner surface of the stent, which would be caused if conventional glass or metal mandrels are used, while simultaneously reducing damage to the inner surface of the stent due to the shielding effect of the polymeric mandrel.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 19, 2012
    Inventors: Svava Maria Atladottir, David C. Gale, Klaus Kleine
  • Polymer Metal and Composite Implantable Medical Devices
    Publication number: 20110313510
    Abstract: A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device. A further aspect of the invention includes device and a method of manufacturing the device that includes a mixture of a biodegradable polymer and bioerodable metallic particles. The mixture may be used to fabricate an implantable medical device or to coat an implantable medical device. In some embodiments, the metallic particles are metallic nanoparticles.
    Type: Application
    Filed: May 27, 2011
    Publication date: December 22, 2011
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: David C. Gale, Bin Huang, John M. Capek
  • POLYMER METAL AND COMPOSITE IMPLANTABLE MEDICAL DEVICES
    Publication number: 20110307053
    Abstract: A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device.
    Type: Application
    Filed: July 7, 2011
    Publication date: December 15, 2011
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: David C. Gale, Bin Huang, John M. Capek, Houdin Dehnad
  • Assembly for manufacturing an implantable polymeric medical device
    Patent number: 8066762
    Abstract: A polymeric tube is positioned on a polymeric mandrel and then laser cut to form an implantable medical device, such as a stent. The method reduces contamination of the inner surface of the stent, which would be caused if conventional glass or metal mandrels are used, while simultaneously reducing damage to the inner surface of the stent due to the shielding effect of the polymeric mandrel.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: November 29, 2011
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Svava Maria Atladottir, David C. Gale, Klaus Kleine