Abstract: The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).

Abstract: The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).

Abstract: An apparatus and method for generating a low concentration of gas within a carrier gas flow employing one or more miniature one-piece cylinders filled under pressure with a pure gas, or a concentrated gas balanced with an inert gas or gas mixture. Released from the cylinder through a pierced or other controlled opening, the flow of the gas is regulated by a pressure regulator and a micro orifice to be blended into a steady stream of diluent gas, typically ambient air, to form a desired gas concentration. No gas is generated if the pressure of the gas in the cylinder, which is monitored constantly by a pressure transducer, is below a predetermined level. The apparatus can be built into a portable device, or an automated docking station (or calibration station) for testing and calibrating gas detection and monitoring instruments, or into a fixed gas detection system for performing such functions.

Abstract: A gas detection instrument comprises a combustible gas sensor and associated circuitry, which supplies power to the sensor and measures and displays resulting sensor response. The supplied power is switched between timed pulses of electricity and steady state electricity, with the intermittent electricity being employed only when no significant change in sensor output has been detected. Alternatively, timed pulses of electricity are maintained, and predictive software algorithms are used to give readings for gas concentration during interruption of the power supply. The sensor operation enables the instrument to respond to rapid changes in gas concentration while minimizing power consumption of the sensor.

Abstract: The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).

Abstract: A gas detection instrument comprises a combustible gas sensor and associated circuitry, which supplies power to the sensor and measures and displays resulting sensor response. The supplied power is switched between timed pulses of electricity and steady state electricity, with the intermittent electricity being employed only when no significant change in sensor output has been detected. Alternatively, timed pulses of electricity are maintained, and predictive software algorithms are used to give readings for gas concentration during interruption of the power supply. The sensor operation enables the instrument to respond to rapid changes in gas concentration while minimizing power consumption of the sensor.

Abstract: The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).

Abstract: The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).

Abstract: The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).

Abstract: The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.

Abstract: A board handling apparatus for receiving, collecting, and stacking boards cut to length by a sawing device includes a frame, a plurality of take-away conveyors adjustably secured to the frame for receiving and collecting the boards, a scissor lift mechanism secured generally under the take-away conveyors for lifting a platform, and a pair of extendable fingers operably supported on the platform for raising/extending/lowering/retracting movement for stacking the collected boards on a pallet. The take-away conveyors are adjustably secured to the frame so that their spacing can be adjusted to an optimal spacing. Also, additional take-away conveyors can be added if desired. The fingers are adjustably secured on the platform so that their spacing can be adjusted to an optimal spacing. Additional fingers can be attached to the platform if desired. Also, additional lift mechanisms can be added with additional platforms to expand the capability of the board handling apparatus.