Patents by Inventor David C. Griffiths

David C. Griffiths has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetracycline compositions
    Patent number: 11944634
    Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: April 2, 2024
    Assignee: MELINTA SUBSIDIARY CORP.
    Inventors: David C. Griffith, Serge Boyer, Scott Hecker, Michael N. Dudley
  • THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES
    Publication number: 20230277571
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: May 9, 2023
    Publication date: September 7, 2023
    Inventors: Gavin HIRST, Raja REDDY, Scott J. HECKER, Maxim TOTROV, David C. GRIFFITH, Olga RODNY, Michael N. DUDLEY, Serge Henri BOYER
  • Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 11684629
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: June 27, 2023
    Assignee: MELINTA SUBSIDIARY CORP.
    Inventors: Gavin Hirst, Raja Reddy, Scott J. Hecker, Maxim Totrov, David C. Griffith, Olga Lomovskaya, Michael N. Dudley, Serge Henri Boyer
  • BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20230151029
    Abstract: Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, ?-lactamase inhibitors (BLIs). The boronic acid derivatives disclosed herein can be used in combination with various antibiotics to treat resistant bacteria.
    Type: Application
    Filed: March 17, 2021
    Publication date: May 18, 2023
    Inventors: Raja K. Reddy, David C. Griffith, Emily Rigsbee, Serge Henri Boyer, Scott J. Hecker, Matthew Jonathan Jones
  • THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES
    Publication number: 20220125813
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: July 16, 2021
    Publication date: April 28, 2022
    Inventors: Gavin HIRST, Raja REDDY, Scott J. HECKER, Maxim TOTROV, David C. GRIFFITH, Olga LOMOVSKAYA, Michael N. DUDLEY, Serge Henri BOYER
  • TOPICAL USE OF LEVOFLOXACIN FOR REDUCING LUNG INFLAMMATION
    Publication number: 20220080047
    Abstract: The present invention relates to methods and compositions for the treatment of pulmonary inflammation. In particular, methods and compositions using aerosol levofloxacin or ofloxacin to reduce pulmonary inflammation are provided.
    Type: Application
    Filed: April 26, 2021
    Publication date: March 17, 2022
    Inventors: Michael N. DUDLEY, Ruslan Y. TSIVKOVSKI, David C. GRIFFITH, Olga RODNY
  • AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF
    Publication number: 20220047604
    Abstract: Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
    Type: Application
    Filed: March 26, 2021
    Publication date: February 17, 2022
    Inventors: Mark W. SURBER, Keith A. BOSTIAN, Michael N. DUDLEY, Olga RODNY, David C. GRIFFITH
  • Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 11090319
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: August 17, 2021
    Assignee: MELINTA SUBSIDIARY CORP.
    Inventors: Gavin Hirst, Raja Reddy, Scott J. Hecker, Maxim Totrov, David C. Griffith, Olga Lomovskaya, Michael N. Dudley, Serge Henri Boyer
  • USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS
    Publication number: 20210228589
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Application
    Filed: August 28, 2020
    Publication date: July 29, 2021
    Inventors: Jeffery S. LOUTIT, Elizabeth E. MORGAN, Michael N. DUDLEY, David C. GRIFFITH, Olga LOMOVSKAYA
  • Topical use of levofloxacin for reducing lung inflammation
    Patent number: 11020481
    Abstract: The present invention relates to methods and compositions for the treatment of pulmonary inflammation. In particular, methods and compositions using aerosol levofloxacin or ofloxacin to reduce pulmonary inflammation are provided.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: June 1, 2021
    Assignee: Horizon Orphan LLC
    Inventors: Michael N. Dudley, Ruslan Y. Tsivkovski, David C. Griffith, Olga Rodny
  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 11007206
    Abstract: Method of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester compound in combination with a carbapenem antibacterial agent such as Biapenem, and the pharmacokinetics studies thereof are provided.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: May 18, 2021
    Assignee: MELINTA SUBSIDIARY CORP.
    Inventors: David C. Griffith, Michael N. Dudley, Olga Lomovskaya
  • AEROSOL FLUOROQUINOLONE FORMULATIONS FOR IMPROVED PHARMACOKINETICS
    Publication number: 20210121472
    Abstract: The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract.
    Type: Application
    Filed: June 16, 2020
    Publication date: April 29, 2021
    Inventors: David C. GRIFFITH, Michael N. DUDLEY, Mark W. SURBER, Keith A. BOSTIAN, Olga RODNY
  • Aerosolized fluoroquinolones and uses thereof
    Patent number: 10987357
    Abstract: Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: April 27, 2021
    Assignee: Horizon Orphan, LLC
    Inventors: Mark W. Surber, Keith A. Bostian, Michael N. Dudley, Olga Rodny, David C. Griffith
  • METHODS OF TREATING BACTERIAL INFECTIONS WITH MINOCYCLINE
    Publication number: 20210052608
    Abstract: Disclosed herein are methods of treating carbapenem-resistant bacterial infections in a subject using various dosages of minocycline.
    Type: Application
    Filed: April 26, 2019
    Publication date: February 25, 2021
    Applicant: Melinta Therapeutics, Inc.
    Inventors: Karen FUSARO, David C. GRIFFITH, Jeffrey S. LOUTIT
  • Use of aerosolized levofloxacin for treating cystic fibrosis
    Patent number: 10792289
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 6, 2020
    Assignee: Horizon Orphan LLC
    Inventors: Jeffery S. Loutit, Elizabeth E. Morgan, Michael N. Dudley, David C. Griffith, Olga Lomovskaya
  • Aerosol fluoroquinolone formulations for improved pharmacokinetics
    Patent number: 10722519
    Abstract: The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: July 28, 2020
    Assignee: Horizon Orphan LLC
    Inventors: David C. Griffith, Michael N. Dudley, Mark W. Surber, Keith A. Bostian, Olga Rodny
  • THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES
    Publication number: 20200222434
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: March 24, 2020
    Publication date: July 16, 2020
    Inventors: Gavin HIRST, Raja REDDY, Scott J. HECKER, Maxim TOTROV, David C. GRIFFITH, Olga RODNY, Michael N. DUDLEY, Serge Henri BOYER
  • CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20200147111
    Abstract: Method of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester compound in combination with a carbapenem antibacterial agent such as Biapenem, and the pharmacokinetics studies thereof are provided.
    Type: Application
    Filed: January 17, 2020
    Publication date: May 14, 2020
    Inventors: David C. GRIFFITH, Michael N. DUDLEY, Olga RODNY
  • Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 10639318
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: May 5, 2020
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 10561675
    Abstract: Method of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester compound in combination with a carbapenem antibacterial agent such as Biapenem, and the pharmacokinetics studies thereof are provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 18, 2020
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: David C. Griffith, Michael N. Dudley, Olga Rodny