Patents by Inventor David C. Howson

David C. Howson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11603550
    Abstract: Systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance are disclosed.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: March 14, 2023
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
  • Publication number: 20220099671
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Application
    Filed: May 12, 2021
    Publication date: March 31, 2022
    Applicant: Accelerate Diagnostics, Inc.
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Patent number: 11054420
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: July 6, 2021
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Publication number: 20180080932
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Application
    Filed: November 30, 2017
    Publication date: March 22, 2018
    Applicant: Accelerate Diagnostics, Inc.
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Patent number: 9841422
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: December 12, 2017
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Publication number: 20170218426
    Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.
    Type: Application
    Filed: April 11, 2017
    Publication date: August 3, 2017
    Applicant: Accelerate Diagnostics, Inc.
    Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
  • Patent number: 9677109
    Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 13, 2017
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
  • Patent number: 9657327
    Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 23, 2017
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
  • Publication number: 20150225762
    Abstract: Generally provided are methods for rapid culture of microorganisms in a sample, including methods for growth and recovery of live microbial cells directly from a sample. Various features include enabling growth of microorganisms in a sample along with a reduction of sample debris that may interfere with microorganism detection, and reduction in toxicities that may inhibit microorganism growth. Further methods for selectively degrading non-viable microbial cells, are provided, for enhanced detection of viable microbial cells following a growth period.
    Type: Application
    Filed: September 10, 2013
    Publication date: August 13, 2015
    Applicant: ACCELERATE DIAGNOSTICS, INC.
    Inventors: Steven W. Metzger, Kenneth Robert Hance, David C. Howson
  • Patent number: 8895255
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: November 25, 2014
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Publication number: 20140323340
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Application
    Filed: July 11, 2014
    Publication date: October 30, 2014
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Publication number: 20140278136
    Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: Accelerate Diagnostics, Inc.
    Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
  • Patent number: 8460887
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: June 11, 2013
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Publication number: 20120077206
    Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.
    Type: Application
    Filed: December 5, 2011
    Publication date: March 29, 2012
    Applicant: Accelr8 Technology Corporation
    Inventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
  • Patent number: 8071319
    Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: December 6, 2011
    Assignee: Accelr8 Technology Corporation
    Inventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
  • Publication number: 20100136570
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Application
    Filed: February 8, 2010
    Publication date: June 3, 2010
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Patent number: 7687239
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: March 30, 2010
    Assignee: Accelrs Technology Corporation
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Publication number: 20080241858
    Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.
    Type: Application
    Filed: January 28, 2008
    Publication date: October 2, 2008
    Inventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
  • Patent number: 7341841
    Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: March 11, 2008
    Assignee: Accelr8 Technology Corporation
    Inventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
  • Patent number: 5368030
    Abstract: The device of the present application, an adhesive disk, relates to non-invasive multi-modality radiographic surface markers and provides means for marking patients and diagnostic images taken of those patients through different methods including X-Ray, Computerized Tomography, Positron Emission Tomograph, and Nuclear Magnetic Resonance Imaging among others. The device of the present application also provides means for enabling the accurate location of internal structures of a patient.
    Type: Grant
    Filed: September 9, 1992
    Date of Patent: November 29, 1994
    Assignee: Izi Corporation
    Inventors: Simion J. Zinreich, Eva S. Zinreich, David C. Howson