Patents by Inventor David C. Howson
David C. Howson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11603550Abstract: Systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance are disclosed.Type: GrantFiled: April 11, 2017Date of Patent: March 14, 2023Assignee: Accelerate Diagnostics, Inc.Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
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Publication number: 20220099671Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: May 12, 2021Publication date: March 31, 2022Applicant: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Patent number: 11054420Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: November 30, 2017Date of Patent: July 6, 2021Assignee: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20180080932Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: November 30, 2017Publication date: March 22, 2018Applicant: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Patent number: 9841422Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: July 11, 2014Date of Patent: December 12, 2017Assignee: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20170218426Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.Type: ApplicationFiled: April 11, 2017Publication date: August 3, 2017Applicant: Accelerate Diagnostics, Inc.Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
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Patent number: 9677109Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.Type: GrantFiled: March 13, 2014Date of Patent: June 13, 2017Assignee: Accelerate Diagnostics, Inc.Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
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Patent number: 9657327Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: GrantFiled: March 15, 2013Date of Patent: May 23, 2017Assignee: Accelerate Diagnostics, Inc.Inventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Publication number: 20150225762Abstract: Generally provided are methods for rapid culture of microorganisms in a sample, including methods for growth and recovery of live microbial cells directly from a sample. Various features include enabling growth of microorganisms in a sample along with a reduction of sample debris that may interfere with microorganism detection, and reduction in toxicities that may inhibit microorganism growth. Further methods for selectively degrading non-viable microbial cells, are provided, for enhanced detection of viable microbial cells following a growth period.Type: ApplicationFiled: September 10, 2013Publication date: August 13, 2015Applicant: ACCELERATE DIAGNOSTICS, INC.Inventors: Steven W. Metzger, Kenneth Robert Hance, David C. Howson
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Patent number: 8895255Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: February 8, 2013Date of Patent: November 25, 2014Assignee: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20140323340Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: July 11, 2014Publication date: October 30, 2014Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20140278136Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Accelerate Diagnostics, Inc.Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
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Patent number: 8460887Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: February 8, 2010Date of Patent: June 11, 2013Assignee: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20120077206Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: ApplicationFiled: December 5, 2011Publication date: March 29, 2012Applicant: Accelr8 Technology CorporationInventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Patent number: 8071319Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: GrantFiled: January 28, 2008Date of Patent: December 6, 2011Assignee: Accelr8 Technology CorporationInventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Publication number: 20100136570Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: February 8, 2010Publication date: June 3, 2010Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Patent number: 7687239Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: July 8, 2004Date of Patent: March 30, 2010Assignee: Accelrs Technology CorporationInventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20080241858Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: ApplicationFiled: January 28, 2008Publication date: October 2, 2008Inventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Patent number: 7341841Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: GrantFiled: December 16, 2005Date of Patent: March 11, 2008Assignee: Accelr8 Technology CorporationInventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Patent number: 5368030Abstract: The device of the present application, an adhesive disk, relates to non-invasive multi-modality radiographic surface markers and provides means for marking patients and diagnostic images taken of those patients through different methods including X-Ray, Computerized Tomography, Positron Emission Tomograph, and Nuclear Magnetic Resonance Imaging among others. The device of the present application also provides means for enabling the accurate location of internal structures of a patient.Type: GrantFiled: September 9, 1992Date of Patent: November 29, 1994Assignee: Izi CorporationInventors: Simion J. Zinreich, Eva S. Zinreich, David C. Howson