Abstract: The present disclosure relates to non-natural NKG2D receptors attached to mammalian cell surfaces wherein the non-natural receptors do not directly signal or directly activate the cell when the receptor is bound by cognate non-natural ?1-?2 domains of NKG2D ligands modified to specifically bind the non-natural NKG2D receptors. The non-natural ?1-?2 domains of NKG2D ligands may be attached to heterologous atoms or molecules including polypeptides, in some embodiments cytokines or modified cytokines, antibodies or fragments of antibodies.

Abstract: The present disclosure provides for a compound according to formula (I) or a pharmaceutically acceptable salt thereof as CaV1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.

Abstract: The present disclosure provides for a compound according to formula (I) or a pharmaceutically acceptable salt thereof as CaV1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.

Abstract: A bone clamp having a first jaw, an opposed second jaw and a drill guide, the drill guide being attached to the first jaw so that bone held between the first jaw and the second jaw can be drilled by a drill inserted through the drill guide, the first jaw having a longitudinal axis. The drill guide can be ball shaped at one distal end thereof that is positioned sufficiently within and retained within a corresponding cavity of the first jaw so that the angle of the drill guide can be adjusted to compound angles in the longitudinal and transverse directions in relation to the longitudinal axis of the first jaw. The bone clamp preferably comprises an organic polymer that is relatively transparent to X-rays.

Abstract: A bone clamp having a first jaw, an opposed second jaw and a drill guide, the drill guide being attached to the first jaw so that bone held between the first jaw and the second jaw can be drilled by a drill inserted through the drill guide, the first jaw having a longitudinal axis. The drill guide can be ball shaped at one distal end thereof that is positioned sufficiently within and retained within a corresponding cavity of the first jaw so that the angle of the drill guide can be adjusted to compound angles in the longitudinal and transverse directions in relation to the longitudinal axis of the first jaw. The bone clamp preferably comprises an organic polymer that is relatively transparent to X-rays.

Abstract: A method for processing an incoming electronic message containing raw data includes the steps of: providing a database having a plurality of stored records, each stored file having searchable data and output data; selecting at least a subset of the raw data from the incoming electronic message to produce search criteria; searching the database to locate a stored record having searchable data substantially matching the search criteria; and automatically replacing at least a subset of the raw data of the incoming electronic message with the output data associated with the located stored record.