Patents by Inventor David C. Klein

David C. Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020002144
    Abstract: The present invention provides a method of producing a bisubstrate inhibitor in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell. Further provided is a method of inhibiting the activity of an acetyltransferase in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell under conditions whereby a bisubstrate inhibitor will be produced, thereby inhibiting the activity of the acetyltransferase in the cell.
    Type: Application
    Filed: July 20, 2001
    Publication date: January 3, 2002
    Applicant: The Government of the United States of America, Department of Health & Human Services
    Inventors: David C. Klein, M. A.A. Namboodiri, Joan L. Weller, Jeffrey A. Kowalak, Anthony K. Ho
  • Patent number: 5182215
    Abstract: A novel method of diagnosing pineal cell tumors by detecting S-antigen in CSF is described.
    Type: Grant
    Filed: June 19, 1989
    Date of Patent: January 26, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David C. Klein, Horst W. Korf, Jeffrey N. Bruce
  • Patent number: 5116867
    Abstract: Chemicals are disclosed which are useful for inhibiting the actions of adenosine in mammals, comprising: L-propranolol, or D-propranolol, or alprenolol and derivatives thereof for parenteral or topical administration are disclosed for purposes of achieving desired circulating concentrations in the range of 10 nanogram to 10 milligrams per kilogram.D-Propranolol is of special interest because it is relatively inactive as a .beta.-adrenergic blocking agent. Specific uses of D-propranolol include the treatment of asthma, chronic obstructive pulmonary disease, A-V node conduction disturbances; apnea of preterm infants, pulmonary hypertension, headaches, migraine, and in attention-deficit disorder. D-Propranolol might also be used as a substitute for xanthines in beverages to produce a feeling of well being, awakeness, awareness and increased performance.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: May 26, 1992
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: David C. Klein, Olga Nikodijevic
  • Patent number: 5009316
    Abstract: A test tube cassette system and cassettes for use therein. Each cassette has a plurality of sample storage test tubes formed therein. The walls of the test tubes are planar thus providing superior optical characteristics. The cassettes are preferably molded of optically clear crystal polystyrene styrene. The test tubes cassette system also includes a rack for supporting and precisely positioning a plurality of cassettes. The system may also include either a plurality of stoppers for sealing the test tubes or a filter cassette adapted for insertion into the test tubes.In accordance with a further preferred embodiment of the invention, the test tube cassette system of the present invention is particularly well adapted for automatic processing of the samples contained within the test tubes of the cassettes.
    Type: Grant
    Filed: May 12, 1989
    Date of Patent: April 23, 1991
    Inventor: David C. Klein
  • Patent number: 4877134
    Abstract: A test tube cassette system and cassettes for use therein. Each cassette has a plurality of sample storage test tubes formed therein. The walls of the test tubes are planar thus providing superior optical characteristics. The cassettes are preferably molded of optically clear crystal polystyrene styrene. The test tubes cassette system also includes a rack for supporting and precisely positioning a plurality of cassettes. The system may also include either a plurality of stoppers for sealing the test tubes or a filter cassette adapted for insertion into the test tubes.In accordance with a further preferred embodiment of the invention, the test tube cassette system of the present invention is particularly well adapted for automatic processing of the samples contained within the test tubes of the cassettes.
    Type: Grant
    Filed: March 29, 1988
    Date of Patent: October 31, 1989
    Inventor: David C. Klein