Patents by Inventor David C. Prior

David C. Prior has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for collisional activation of charged particles
    Patent number: 8541737
    Abstract: A collision cell is disclosed that provides ion activation in various selective modes. Ion activation is performed inside selected segments of a segmented quadrupole that provides maximum optimum capture and collection of fragmentation products. The invention provides collisional cooling of precursor ions as well as product fragments and further allows effective transmission of ions through a high pressure interface into a coupled mass analysis instrument.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: September 24, 2013
    Assignee: Battelle Memorial Institute
    Inventors: Yehia M. Ibrahim, Mikhail E. Belov, David C. Prior
  • SYSTEM AND METHOD FOR COLLISIONAL ACTIVATION OF CHARGED PARTICLES
    Publication number: 20110127417
    Abstract: A collision cell is disclosed that provides ion activation in various selective modes. Ion activation is performed inside selected segments of a segmented quadrupole that provides maximum optimum capture and collection of fragmentation products. The invention provides collisional cooling of precursor ions as well as product fragments and further allows effective transmission of ions through a high pressure interface into a coupled mass analysis instrument.
    Type: Application
    Filed: April 28, 2010
    Publication date: June 2, 2011
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Yehia M. Ibrahim, Mikhail E. Belov, David C. Prior
  • Ion funnel ion trap and process
    Patent number: 7888635
    Abstract: An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of ˜1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of ˜10,000,000 elementary charges, 4) ion ejection time of 40 to 200 ?s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: February 15, 2011
    Assignee: Battelle Memorial Institute
    Inventors: Mikhail E. Belov, Yehia M. Ibrahim, Biran H. Clowers, David C. Prior, Richard D. Smith
  • Ion funnel ion trap and process
    Publication number: 20090294662
    Abstract: An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of ˜1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of ˜10,000,000 elementary charges, 4) ion ejection time of 40 to 200 ?s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.
    Type: Application
    Filed: May 30, 2008
    Publication date: December 3, 2009
    Inventors: Mikhail E. Belov, Yehia M. Ibrahim, Brian H. Clowers, David C. Prior, Richard D. Smith