Abstract: Embodiments of an inline inspection (“ILI”) tool (10) of this disclosure include a plurality of composite field systems (20) arranged circumferentially about the body of the ILI tool, each composite field system including multiple magnetic circuits (60) to produce a composite or resultant angled field © relative to the target, along with a sensor array or circuit (40) configured for magnetic flux leakage (“MFL”) or magnetostrictive electro-magnetic acoustic transducers (“EMAT”) implementations. In embodiments, the pole magnets (61) of the magnetic circuits are oriented in the axial direction of the tool body rather than in the direction of the resultant angled field. The same is true of the sensors (43). This composite field system approach provides options to design geometries that were not previously possible in prior art single-circuit helical MFL designs and EMAT designs.

Abstract: Embodiments of an inline inspection (“ILI”) tool (10) of this disclosure include a plurality of composite field systems (20) arranged circumferentially about the body of the ILI tool, each composite field system including multiple magnetic circuits (60) to produce a composite or resultant angled field © relative to the target, along with a sensor array or circuit (40) configured for magnetic flux leakage (“MFL”) or magnetostrictive electro-magnetic acoustic transducers (“EMAT”) implementations. In embodiments, the pole magnets (61) of the magnetic circuits are oriented in the axial direction of the tool body rather than in the direction of the resultant angled field. The same is true of the sensors (43). This composite field system approach provides options to design geometries that were not previously possible in prior art single-circuit helical MFL designs and EMAT designs.

Abstract: Embodiments of an inline inspection (“ILP”) tool (10) of this disclosure include a plurality of composite field systems (20) arranged circumferentially about the body of the IL1 tool, each composite field system including multiple magnetic circuits (60) to produce a composite or resultant angled field © relative to the target, along with a sensor array or circuit (40) configured for magnetic flux leakage (“MFL”) or magnetostrictive electro-magnetic acoustic transducers (“EMAT”) implementations. In embodiments, the pole magnets (61) of the magnetic circuits are oriented in the axial direction of the tool body rather than in the direction of the resultant angled field. The same is true of the sensors (43). This composite field system approach provides options to design geometries that were not previously possible in prior art single-circuit helical MFL designs and EMAT designs.

Abstract: There is provided a polymer having a side chain of general formula (I) in which R may be any suitable alkyl, oxyalkyl, aryl or oxyaryl linking group R is preferably C1-6 alkyl (especially —CH2—), a benzene group or a group —CH2—O-Phe-. Generally, the side chain will be attached to an ethylene moiety forming part of the backbone of the polymer. Preferred polymers include polystyrene. The polymer is useful as a support for solid phase chemical reactions especially combinatorial chemical synthesis.

Abstract: There is provided a polymer having a side chain of general formula (I) in which R may be any suitable alkyl, oxyalkyl, aryl or oxyaryl linking group R is preferably C1-6 alkyl (especially —CH2—), a benzene group or a group —CH2—O—Phe—. Generally, the side chain will be attached to an ethylene moiety forming part of the backbone of the polymer. Preferred polymers include polystyrene. The polymer is useful as a support for solid phase chemical reactions especially combinatorial chemical synthesis.

Abstract: The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included.The compounds are expected to be especially useful in asthma and rheumatoid arthritis.

Abstract: Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.

Abstract: Methods for using substituted phenoxy-, 1-, and 2-naphthalenyloxy-, indenyl-, indolyl-, benzo[b]-furanyl-, and benzo[b]thienylcarboxamides of 7,8-(substituted-diamino)-1-oxaspiro[4.5]decanes as cerebrovascular, diuretic, and antiinflammatory agents are disclosed. Pharmaceutical compositions employing the compounds are also disclosed.

Abstract: The invention concerns a series of novel 2-amino-monomethoxycyclohexyl amides having analgesic and neuroprotective activity. The compounds bind selectivity to the kappa opioid receptor. Pharmaceutical compositions containing the compounds, methods of using them, and processes for preparing them are also disclosed.

Abstract: Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents having very high kappa-opioid affinity and selectivity and potency and useful as analgesics, diuretics, antiinflammatory and psychotherapeutic agents are disclosed. Methods for making the compounds and pharmaceutical compositions containing them are also disclosed.

Abstract: Methods for using substituted phenoxy-, 1-, and 2-naphthalenyloxy-, indenyl-, indolyl-, benzo[b]-furanyl-, and benzo[b]thienylcarboxamides of 7,8-(substituted-diamino)-1-oxaspiro[4.5]decanes as cerebrovascular, diuretic, and antiinflammatory agents are disclosed. Pharmaceutical compositions employing the compounds are also disclosed.

Abstract: Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents having very high kappa-opioid affinity and selectivity and potency and useful as analgesics, diuretics, antiinflammatory and psychotherapeutic agents are disclosed. Methods for making the compounds and pharmaceutical compositions containing them are also disclosed.