Patents by Inventor David C. Watkin

David C. Watkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180291412
    Abstract: The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in a Pseudomonas fluorescens organism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such as E. coli in comparable circumstances. Processes for improved production of isolated mammalian, particularly human, proteins are provided.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 11, 2018
    Inventors: Diane M. Retallack, Charles H. Squires, David C. Watkins, Stacey L. Lee, Frank H. Gaertner, Robert Shutter
  • Patent number: 10041102
    Abstract: The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in a Pseudomonas fluorescens organism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such as E. coli in comparable circumstances. Processes for improved production of isolated mammalian, particularly human, proteins are provided.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: August 7, 2018
    Assignee: PFENEX INC.
    Inventors: Diane M. Retallack, Charles H. Squires, David C. Watkins, Stacey L. Lee, Frank H. Gaertner, Robert Shutter
  • Publication number: 20170051327
    Abstract: The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in a Pseudomonas fluorescens organism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such as E. coli in comparable Circumstances Processes for improved production of isolated mammalian, particularly human, proteins are provided.
    Type: Application
    Filed: August 5, 2016
    Publication date: February 23, 2017
    Inventors: Diane M. Retallack, Charles H. Squires, David C. Watkins, Stacey L. Lee, Frank H. Gaertner, Robert Shutter
  • Patent number: 9458487
    Abstract: The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in a Pseudomonas fluorescens organism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such as E. coli in comparable circumstances Processes for improved production of isolated mammalian, particularly human, proteins are provided.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: October 4, 2016
    Assignee: PFENEX, INC.
    Inventors: Diane M. Retallack, Charles H. Squires, David C. Watkins, Stacey L. Lee, Frank H. Gaertner, Robert Shutter
  • Patent number: 9453251
    Abstract: The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in a Pseudomonas fluorescens organism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such as E. coli in comparable circumstances Processes for improved production of isolated mammalian, particularly human, proteins are provided.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: September 27, 2016
    Assignee: PFENEX INC.
    Inventors: Diane M. Retallack, Charles H. Squires, David C. Watkins, Stacey L. Lee, Frank H. Gaertner, Robert Shutter
  • Patent number: 6071535
    Abstract: The present invention provides for liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver entrapped load material or materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The liposomes of the invention are used to encapsulate both hydrophobic and hydrophilic load materials. The liposomes formed accordingly are capable of delivering their loads upon the occurrence of a trigger or control condition.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: June 6, 2000
    Assignee: Collaborative Laboratories, Inc.
    Inventors: James A. Hayward, David C. Watkins, Duncan T. Aust
  • Patent number: 5935572
    Abstract: A composition containing a protease and glycosidase is provided for removing nits in the treatment of lice infestation. The protease and glycosidase are separated from each other to prevent the protease from hydrolyzing the glycosidase Separation is accomplished by encapsulating either the protease or glycosidase in a lipidic bilayer vesicle while leaving the other outside the vesicle. The protease and glycosidase destroy complex carbohydrate and protein in nit shells, nit embryos and substances secreted by adult lice. In a method of treatment, an infestation site such as hair is treated with a pediculoside and then with the composition containing a protease and glycosidase, and nits are removed such as by washing.
    Type: Grant
    Filed: January 10, 1997
    Date of Patent: August 10, 1999
    Assignee: Collaborative Laboratories, Inc.
    Inventors: James A. Hayward, David C. Watkins
  • Patent number: 5874105
    Abstract: A liposome for use in encapsulating both hydrophobic and hydrophilic substances (i.e., a "payload"),is disclosed which is capable of delivering their load upon the occurrence of a trigger or control condition. The liposomes are formed to stably encapsulate a particular active agent to form a delivery vehicle for the agent. The liposomes of the delivery vehicle are stable in a particular environment but become unstable or permeable if passed from the stable environment (e.g., characteristic of a particular pH and/or temperature and/or ionic strength) to a changed or unstable environment, thereby delivering their payload.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: February 23, 1999
    Assignee: Collaborative Laboratories, Inc.
    Inventors: David C. Watkins, Thomas J. Vichroski, James A. Hayward
  • Patent number: 5750882
    Abstract: Method and apparatus for measuring the permeability of polymer film materials such as used in super-insulation powder-filled evacuated panels (PEPs) reduce the time required for testing from several years to weeks or months. The method involves substitution of a solid non-outgassing body having a free volume of between 0% and 25% of its total volume for the usual powder in the PEP to control the free volume of the "body-filled panel". Pressure versus time data for the test piece permit extrapolation to obtain long term performance of the candidate materials.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: May 12, 1998
    Assignee: Lockheed Martin Energy Research Corporation
    Inventors: Gerard M. Ludtka, Thomas G. Kollie, David C. Watkin, David G. Walton
  • Patent number: 5545593
    Abstract: A method of aligning layers in an integrated circuit device includes associating an alignment target (10, 50) with each layer. Each alignment target (10, 50) has multiple edges created through a boxed frame configuration (16, 18). During semiconductor device fabrication, each alignment target (10, 50) is formed into an alignment structure (200) on the semiconductor wafer. For correspondingly aligned layers, one alignment target of one layer falls within the alignment target of a correspondingly aligned layer within the alignment structure (200). The edges of each alignment target (10, 50) are scanned to determine a center point for each alignment target (10, 50). The layers of the corresponding alignment targets (10, 50) are aligned if the center points calculated from the scanning process performed on the edges of each alignment target coincide along x-axis and y-axis planes.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: August 13, 1996
    Assignee: Texas Instruments Incorporated
    Inventors: David C. Watkins, Lowell M. Bramer, Christopher F. Gerling
  • Patent number: 4755050
    Abstract: According to the invention there is provided a standard for monitoring the calibration of optical line width measuring machines which includes an opaque sheet having two spaced apart slots. Preferably, the sheet material is a metal such as chromium deposited on a transparent substrate.
    Type: Grant
    Filed: July 18, 1986
    Date of Patent: July 5, 1988
    Assignee: Texas Instruments Incorporated
    Inventor: David C. Watkins