Patents by Inventor David Calderwood

David Calderwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thienopyridine and furopyridine kinase inhibitors
    Publication number: 20050026944
    Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: May 3, 2004
    Publication date: February 3, 2005
    Inventors: Patrick Betschmann, Andrew Burchat, David Calderwood, Michael Curtin, Steven Davidsen, Heather Davis, Robin Frey, Howard Heyman, Gavin Hirst, Peter Hrnciar, Michael Michaelides, Melanie Muckey, Paul Rafferty, Carol Wada
  • Thienopyridine kinase inhibitors
    Publication number: 20050020619
    Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: July 24, 2003
    Publication date: January 27, 2005
    Inventors: Patrick Betschmann, Andrew Burchat, David Calderwood, Michael Curtin, Steven Davidsen, Heather Davis, Robin Frey, Howard Heyman, Gavin Hirst, Peter Hrnciar, Michael Michaelides, Paul Rafferty
  • Pyrrolopyrimidines as therapeutic agents
    Patent number: 6713474
    Abstract: Chemical compounds having structural formula I and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatiod arthritis, disorders of the immune system, trasplant rejections and imflammatory disorders.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: March 30, 2004
    Assignee: Abbott GmbH & Co. KG
    Inventors: Gavin C. Hirst, David Calderwood, Rainer Munschauer, Lee D. Arnold, David N. Johnston, Paul Rafferty
  • Pyrazolopyrimidines as therapeutic agents
    Publication number: 20040006083
    Abstract: The present invention provides compounds of Formula I, 1
    Type: Application
    Filed: July 19, 2002
    Publication date: January 8, 2004
    Inventors: Gavin C. Hirst, Paul Rafferty, Kurt Ritter, David Calderwood, Neil Wishart, Lee D. Arnold, Michael M. Friedman
  • Pyrazolopyrimidines as therapeutic agents
    Patent number: 6660744
    Abstract: The present invention is directed to pyrazolopyrimidine derivatives which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: December 9, 2003
    Assignee: Abbott GmbH & Co. KG
    Inventors: Gavin C. Hirst, Paul Rafferty, Kurt Ritter, David Calderwood, Neil Wishart, Lee D. Arnold, Michael M. Friedman
  • Kinase inhibitors
    Publication number: 20030225098
    Abstract: The present application is directed to pyrazolopyrirnidine and furopyrimidine analogs of the formula (I) 1
    Type: Application
    Filed: March 21, 2003
    Publication date: December 4, 2003
    Inventors: Gavin C. Hirst, Lee D. Arnold, Andrew Burchat, Neil Wishart, David Calderwood, Carol K. Wada, Michael R. Michaelides, Zhiqin Ji, Melanie Muckey
  • 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS
    Publication number: 20030187001
    Abstract: Chemical compounds having structural formula I 1
    Type: Application
    Filed: September 17, 1999
    Publication date: October 2, 2003
    Inventors: DAVID CALDERWOOD, LEE ARNOLD, HORMOZ MAZDIYASNI, GAVIN C. HIRST, BOJUAN B. DENG, DAVID N. JOHNSTON, PAUL RAFFERTY, GERALD B. TOMETZKI, HELEN L. TWIGGER, RAINER MUNSCHAUER
  • Method of identifying inhibitors of Lck
    Publication number: 20030175935
    Abstract: The present invention relates to polypeptides which comprise the ligand binding domain of Lck, crystalline forms of these polypeptides, and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Lck. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential selective inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain selectively.
    Type: Application
    Filed: August 5, 2002
    Publication date: September 18, 2003
    Inventors: David W. Borhani, David Calderwood, Richard W. Dixon, Gavin C. Hirst, Peter Hrnciar, Andreas Loew, Adelaine Leung, Kurt Ritter
  • Pyrrolopyrimidines as therapeutic agents
    Publication number: 20030153752
    Abstract: Chemical compounds having structural formula I 1
    Type: Application
    Filed: March 29, 2000
    Publication date: August 14, 2003
    Inventors: Gavin C. Hirst, David Calderwood, Rainer Munschauer, Lee D. Arnold, David N. Johnston, Paul Rafferty
  • Pyrazolopyrimidines as therapeutic agents
    Publication number: 20020156081
    Abstract: The present invention provides compounds of Formula I, 1
    Type: Application
    Filed: March 22, 2001
    Publication date: October 24, 2002
    Applicant: Abbott Laboratories
    Inventors: Gavin C. Hirst, Paul Rafferty, Kurt Ritter, David Calderwood, Neil Wishart, Lee D. Arnold, Michael M. Friedman