Abstract: Provided herein are designs of multi-specific polypeptides for binding target cells and engaging T cells. In some embodiments, the multi-specific polypeptide comprises a first binding domain that specifically binds to a T cell receptor beta variable region (TCR?V), or a T cell receptor alpha variable region (TCR?V) expressed on the T cell, and a second binding domain that specifically binds to an antigen (e.g., CD19) on the target cell, and a Fc region. In some embodiments, both the first and the second binding domains are located on the same polypeptide chain of the Fc region (e.g., a Fc region polypeptide chain comprising a Knob mutation). These multi-specific polypeptides are not only effective in killing the target cells, but also expands early memory populations that maintains and/or replenishes effector populations over time.

Abstract: Disclosed herein are polypeptides or polypeptide complexes comprising an antibody or antigen binding fragment thereof that binds to six-transmembrane epithelial antigen of the prostate-1 (STEAP-1).

Abstract: Provided herein are multispecific antibodies that selectively bind to PSMA and effector cell antigens such as CD3, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same.

Abstract: Disclosed herein are polypeptides or polypeptide complexes comprising an antibody or antigen binding fragment thereof that binds to six-transmembrane epithelial antigen of the prostate-1 (STEAP-1) and a second antibody or antigen binding fragment thereof that binds to CD3.

Abstract: A generative content tracking system may include one or more of a plurality of content container generating instructions, a processor configured to execute the content container generating instructions, and a non-transitory memory coupled to the processor configured to store the content container generating instructions. A generative content tracking system may include a communication service coupled to a network interface, the communication service configured to receive a content container generation request.

Abstract: Systems as described herein may include document scanning to identify problems with the documents. A document scanning system may determine a scope of a document scan. The system may initiate a silent mode of a browser application and send a request to access an enterprise document repository. The system may be granted read-only access and determine page elements associated with a document within the scope. Based on the page elements, the system may use a machine learning model to determine an indication of one or more problems with a document. Accordingly, the system may generate a health report for each document within the scope of the document scan.

Abstract: Described herein are compositions and formulations comprising a recombinant polypeptide. Related methods and uses of these compositions and formulations are also described herein.

Abstract: Provided herein are multispecific antibodies that selectively bind to PSMA and effector cell antigens such as CD3, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same.

Abstract: Disclosed herein are methods of inhibiting an interaction of a T cell receptor with a peptide-major histocompatibility complex comprising administering inhibitory peptides that bind to the T cell receptor without the aid of a major histocompatibility complex to inhibit the interaction, and methods of identifying the inhibitory peptides.

Abstract: Disclosed is an armored cable assembly including a core having a notched assembly tape about a plurality of conductors. A metal sheath surrounds the core.

Abstract: A generative content registration system may include a processor. A generative content registration system may include a non-transitory memory coupled to the processor configured to store a generative content registration database comprising generative content registration data. A generative content registration system may include a communication service coupled to a network interface, the communication service configured to receive generative content registration-related service requests.

Abstract: Disclosed is a cable assembly including at least one conductor and a metal sheath disposed over the at least one conductor, the metal sheath including a continuous strip of metal having a plurality of revolutions. A first revolution of the plurality of revolutions may include a first section having a curved profile extending into an interior cavity of the metal sheath, and a second section extending from the first section, the second section extending along a lengthwise axis, wherein a length of the second section, along the lengthwise axis, is at least two times as large as a diameter of the first section when the metal sheath is in a linear configuration. The first revolution may further include a third section extending from the second section, the third section including a free end terminating within a recess defined by a curved profile of a first section of an adjacent revolution.

Abstract: Disclosed herein are recombinant antibodies or antigen binding fragments thereof that comprise a CD3 binding domain that has been optimized via alanine scanning mutagenesis. In some embodiments, the recombinant antibodies or antigen binding fragments thereof further comprise an antigen binding domain.

Abstract: Disclosed herein are recombinant antibodies or antigen binding fragments thereof that comprise a CD3 binding domain that has been optimized via alanine scanning mutagenesis. In some embodiments, the recombinant antibodies or antigen binding fragments thereof further comprise an antigen binding domain.

Abstract: Disclosed is an armored cable assembly which may include a plurality of conductors and a metal sheath disposed over the plurality of conductors. The metal sheath may have a plurality of revolutions extending helically along a lengthwise axis, each of the plurality of revolutions including a first section having a curved profile, a second section extending from the first section, the second section having a planar profile, and a third section extending from the second section. The third section may include a free end angled towards an interior cavity of the metal sheath, the free end extending past a plane defined by a bottom most point of the first section of an adjacent revolution, the plane extending perpendicular to the second section.

Abstract: Provided herein are multispecific antibodies that selectively bind to EGFR and effector cell antigens such as CD3, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same.

Abstract: Provided herein are multispecific antibodies that selectively bind to PSMA and effector cell antigens such as CD3, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same.

Abstract: Disclosed is a cable assembly including at least one conductor and a metal sheath disposed over the at least one conductor, the metal sheath including a continuous strip of metal having a plurality of revolutions. A first revolution of the plurality of revolutions may include a first section having a curved profile extending into an interior cavity of the metal sheath, and a second section extending from the first section, the second section extending along a lengthwise axis, wherein a length of the second section, along the lengthwise axis, is at least two times as large as a diameter of the first section when the metal sheath is in a linear configuration. The first revolution may further include a third section extending from the second section, the third section including a free end terminating within a recess defined by a curved profile of a first section of an adjacent revolution.