Patents by Inventor David Canner

David Canner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for overcoming immunosuppression
    Patent number: 11739156
    Abstract: The present invention discloses novel methods, compositions, and uses thereof for removing or overcoming immunosuppression. More specifically, the methods and compositions disclosed herein target effector Treg cells by modulating ST2 and/or IL-33 signaling using pharmaceutical inhibitors and/or genetic ablation, whereby the levels and/or activities of effector Treg cells in a tumor microenvironment are inhibited, and the infiltration of effector CD8+ cytotoxic T cells into tumor microenvironment increases. As a result, tumor growth is inhibited and tumor volume is reduced. The present invention also provides methods for identifying and isolating effector Treg cells in a population of heterogeneous cells.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: August 29, 2023
    Assignee: The Broad Institute, Inc. Massachusetts Institute of Technology
    Inventors: Amy Li, Rebecca H. Herbst, Aviv Regev, Tyler Jacks, David Canner
  • METHODS AND COMPOSITIONS FOR OVERCOMING IMMUNOSUPPRESSION
    Publication number: 20200216551
    Abstract: The present invention discloses novel methods, compositions, and uses thereof for removing or overcoming immunosuppression. More specifically, the methods and compositions disclosed herein target effector Treg cells by modulating ST2 and/or IL-33 signaling using pharmaceutical inhibitors and/or genetic ablation, whereby the levels and/or activities of effector Treg cells in a tumor microenvironment are inhibited, and the infiltration of effector CD8+ cytotoxic T cells into tumor microenvironment increases. As a result, tumor growth is inhibited and tumor volume is reduced. The present invention also provides methods for identifying and isolating effector Treg cells in a population of heterogeneous cells.
    Type: Application
    Filed: January 6, 2020
    Publication date: July 9, 2020
    Inventors: Amy Li, Rebecca H. Herbst, Aviv Regev, Tyler Jacks, David Canner