Abstract: The present disclosure relates to an electrochemical reactor capable of processing an organic mixture comprising a suspension of a solid and a liquid, wherein the electrochemical reactor comprises an inner electrode, an outer electrode, wherein the inner electrode and the outer electrode are arranged concentrically forming a first cavity therebetween, a first inlet configured for introducing the liquid into the first cavity of the electrochemical reactor, a second inlet configured for introducing the solid into the first cavity of the electrochemical reactor, wherein the first inlet and the second inlet are arranged such that the liquid and the solid are introduced separately, wherein the inner electrode is configured to be rotatable around its longitudinal axis, wherein the inner electrode comprises one or more mixing elements.

Abstract: The present disclosure relates to a process for preparing a nor-opioid compound wherein an opioid precursor compound is electrochemically N-demethylated. The present disclosure further relates to a process for preparing an opioid antagonist compound, wherein an opioid precursor compound is electrochemically N-demethylated and the thus obtained nor-opioid compound is alkylated again at its secondary amine functional group.

Abstract: The present invention relates to processes useful in the preparation of morphine analogs and derivatives, such as naltrexone, naloxone and nalbuphine and intermediates in the synthesis of said morphine analogs and derivatives. In a particular example, the process begins with for example oxymorphone, oxycodone, 14-hydroxycodeinone or 14-hydroxymorphinone, and includes the formation of an oxazolidine-containing intermediate using catalytic oxidation.