Abstract: The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.

Abstract: Combination therapies comprising novel TNF-? proteins for the treatment of TNF-? related disorders are provided herein.

Abstract: An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.

Abstract: The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.

Abstract: An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.

Abstract: Magnetic resonance images are acquired by combining images obtained using two different spatial sensitivity profiles, 1?, 2?. The transverse magnetisation is caused to adopt such a profile 1? in one direction, resulting, in two dimensions, to a series of alternating stripes of respectively strong and weak, e.g. zero, transverse magnetisation. The regions of strong transverse magnetisation correspond to regions of high sensitivity in the acquired image. A complementary sensitivity profile 2? is stored as longitudinal magnetisation. A first image is then acquired in which the pixels are centered on the regions of high sensitivity within the first sensitivity profile 1?. The complementary sensitivity profile 2? is then recalled by inserting an additional gradient pulse and then a radio-frequency pulse into the pulse sequence and a second image acquired. As with the first image, the pixels are centered on the high-sensitivity regions, but these are mid-way between those within the first sensitivity profile 1?.

Abstract: A multi-purpose hanger includes a hook portion for supporting the hanger. The hanger has a pair of opposing shoulder portions extending outwardly from the hook portion. Each of the shoulder portions has a detachable end piece in communication therewith. Each of the end pieces can be attached to their respective shoulder portions such that the end is pointed either upwardly or downwardly as required.

Abstract: A multi-purpose hanger includes a hook portion for supporting the hanger. The hanger has a pair of opposing shoulder portions extending outwardly from the hook portion. Each of the shoulder portions has a detachable end piece in communication therewith. Each of the end pieces can be attached to their respective shoulder portions such that the end is pointed either upwardly or downwardly as required.