Abstract: The present invention provides IP4-4,6 substituted derivatives, their methods of synthesis and their uses. In some aspects, the IP4-4,6 derivative is a compound of formula I wherein R1, R3, R7, and R11 are OPO32?, and R5 and R9 are selected from the group consisting of —O(Alkyl)nX, —O(Alkyl)yCy(Alkyl2)y-Z, —O(Alkyl)yA(Alkyl)y-Z?, and their thiophosphate analogs. Also provided are methods, pharmaceutical compositions and formulations, methods of use, articles of manufacture, and kits for the treatment of diseases and conditions such as pathological crystallization-related diseases and conditions.

Abstract: This invention teaches a multi-sensor quality inference system for additive manufacturing. This invention still further teaches a quality system that is capable of discerning and addressing three quality issues: i) process anomalies, or extreme unpredictable events uncorrelated to process inputs; ii) process variations, or difference between desired process parameters and actual operating conditions; and iii) material structure and properties, or the quality of the resultant material created by the Additive Manufacturing process. This invention further teaches experimental observations of the Additive Manufacturing process made only in a Lagrangian frame of reference. This invention even further teaches the use of the gathered sensor data to evaluate and control additive manufacturing operations in real time.

Abstract: A biodegradable toy foam dart is described herein, wherein the biodegradable toy foam dart includes the biodegradable foam material. The toy foam dart includes a dart body and a dart cap.

Abstract: Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease.

Abstract: Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease.

Abstract: Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease.

Abstract: Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease.

Abstract: An animal headphone assembly for soothing a canine when the canine is exposed to distressing sounds includes a pair of headphones. Each of the headphones has a diameter sufficient to cover ears of a canine for wearing over each of a canine's ears. A plurality of straps is each coupled between each of the headphones to extend around the canine's head for retaining the headphones over the canine's ears. A sound unit is integrated into the headphones to emit sound outwardly therefrom. The sound unit stores a database comprising a plurality of musical songs to emit pleasing sounds into the canine's ears. Each of the musical songs includes concealed binaural beats to soothe the canine.

Abstract: An unmanned aerial vehicle includes a processor and a memory storing instructions executable by the processor. The instructions include receiving diagnostic information from a vehicle, processing the diagnostic information to diagnose a vehicle failure, and outputting repair instructions for addressing the vehicle failure. A corresponding method is also disclosed.

Abstract: Methods of reducing paper dusting in a papermaking process, and a low dusting tissue having increased strength are provided. Application of a polymer comprising at least one amine-containing vinylic or allylic monomer to at least one surface of a paper web during the papermaking process reduces the dusting tendency of the paper, and increases both the wet and dry strength of the paper product.

Abstract: Various examples are provided for digital sound reconstruction using piezoelectric array elements. In one example, a digital loudspeaker includes a fixed frame and an array of transducers disposed on the fixed frame. Individual transducers of the array of transducers can include a flexible membrane disposed on a piezoelectric actuation element positioned over a corresponding opening that extends through the fixed frame. In another example, a method includes forming a flexible membrane structure on a substrate and backetching the substrate opposite the flexible membrane structure. The flexible membrane structure can be formed by disposing a first electrode layer on a substrate, disposing a piezoelectric layer on the first electrode layer and disposing a second electrode layer on the piezoelectric layer. A flexible membrane layer (e.g., polyimide) can be disposed on the second electrode layer.

Abstract: Various examples are provided for digital sound reconstruction using piezoelectric array elements. In one example, a digital loudspeaker includes a fixed frame and an array of transducers disposed on the fixed frame. Individual transducers of the array of transducers can include a flexible membrane disposed on a piezoelectric actuation element positioned over a corresponding opening that extends through the fixed frame. In another example, a method includes forming a flexible membrane structure on a substrate and backetching the substrate opposite the flexible membrane structure. The flexible membrane structure can be formed by disposing a first electrode layer on a substrate, disposing a piezoelectric layer on the first electrode layer and disposing a second electrode layer on the piezoelectric layer. A flexible membrane layer (e.g., polyimide) can be disposed on the second electrode layer.

Abstract: Various examples are provided for digital sound reconstruction using piezoelectric array elements. In one example, a digital loudspeaker includes a fixed frame and an array of transducers disposed on the fixed frame. Individual transducers of the array of transducers can include a flexible membrane disposed on a piezoelectric actuation element positioned over a corresponding opening that extends through the fixed frame. In another example, a method includes forming a flexible membrane structure on a substrate and backetching the substrate opposite the flexible membrane structure. The flexible membrane structure can be formed by disposing a first electrode layer on a substrate, disposing a piezoelectric layer on the first electrode layer and disposing a second electrode layer on the piezoelectric layer. A flexible membrane layer (e.g., polyimide) can be disposed on the second electrode layer.

Abstract: An unmanned aerial vehicle includes a processor and a memory storing instructions executable by the processor. The instructions include receiving diagnostic information from a vehicle, processing the diagnostic information to diagnose a vehicle failure, and outputting repair instructions for addressing the vehicle failure. A corresponding method is also disclosed.

Abstract: A configurable storage device includes a body having a base and multiple displaceable panels connected to the base by ratchet hinges. The body is displaceable between a home position and a deployed position. The deployed position includes various different configurations for holding different items or to meet the application needs of the user.

Abstract: A high volume microfluidic system for producing emulsions includes a fluid distribution network to produce uniformly sized emulsions and encapsulates.

Abstract: A drawer assembly is provided. That drawer assembly includes a drawer and a bezel. The bezel includes an integral drawer centering device whereby smooth sliding action of the drawer in the bezel is provided. The bezel and the integral drawer centering device are molded as a unitary component.

Abstract: A sliding storage compartment assembly for a motor vehicle includes a storage bin slidably received in a storage bin holder by a dual track assembly defined by opposed sets of rails and opposed sets of cooperating tracks. Each of the opposed sets of rails and opposed sets of cooperating tracks are vertically and laterally offset one from another. Each of the opposed sets of rails and each of the opposed sets of cooperating tracks may be vertically offset one from another in a vehicle z-axis direction and laterally offset from one another in a vehicle x-axis direction. The opposed sets of cooperating tracks may be disposed on opposed side walls of the storage bin holder and the opposed sets of rails may be disposed on opposed side walls of the storage bin, or vice-versa. Console assemblies including the sliding storage compartment assembly are described.

Abstract: Various examples are provided for digital sound reconstruction using piezoelectric array elements. In one example, a digital loudspeaker includes a fixed frame and an array of transducers disposed on the fixed frame. Individual transducers of the array of transducers can include a flexible membrane disposed on a piezoelectric actuation element positioned over a corresponding opening that extends through the fixed frame. In another example, a method includes forming a flexible membrane structure on a substrate and backetching the substrate opposite the flexible membrane structure. The flexible membrane structure can be formed by disposing a first electrode layer on a substrate, disposing a piezoelectric layer on the first electrode layer and disposing a second electrode layer on the piezoelectric layer. A flexible membrane layer (e.g., polyimide) can be disposed on the second electrode layer.