Abstract: The present invention relates to certain novel substituted thiophene compounds and the finding that they display useful efficacy in the inhibition of the p38? MAPK enzyme. This provides for use of the compounds in various treatment methodologies related to MAPK inhibition, including the treatment of inflammation.

Abstract: A computer-implemented method of generating an image file of a 3D body model of a user wearing a garment, comprising: (i) receiving one or more two dimensional images of a model wearing a garment, which images provide a view of an outer surface of the garment; (ii) for each two dimensional image, segmenting an image of the garment to produce a set of segmented garment images; (iii) using the set of segmented garment images to generate a complete 3D garment model; (iv) receiving a 3D body model of a user; (v) simulating the complete 3D garment model worn on the 3D body model of the user and, (vi) generating an image file of the 3D body model of the user wearing the complete 3D garment model, using the simulated complete 3D garment model worn on the 3D body model of the user.

Abstract: Systems and methods for identifying comment clusters for panoramic content segments. A panoramic content segment of digital content may be hosted to client computing platforms. User comment information may be received. The user comment information may convey user comments, include time indications for a duration of a content segment, and/or include location indications for a panorama of the panoramic content segment. A comment distribution may be determined from the user comment information. A comment cluster may be identified based on the comment distribution. View information may be received from a client computing platform. Whether a view range associated with the comment cluster identified is located within or outside one or more visible ranges of viewing angles selected by the user may be determined. Alert information may be generated and/or transmitted for effectuating presentation of a notification on the client computing platform associated with the user.

Abstract: A computer-implemented method of generating an image file of a 3D body model of a user wearing a garment, comprising: (i) receiving one or more two dimensional images of a model wearing a garment, which images provide a view of an outer surface of the garment; (ii) for each two dimensional image, segmenting an image of the garment to produce a set of segmented garment images; (iii) using the set of segmented garment images to generate a complete 3D garment model; (iv) receiving a 3D body model of a user; (v) simulating the complete 3D garment model worn on the 3D body model of the user and, (vi) generating an image file of the 3D body model of the user wearing the complete 3D garment model, using the simulated complete 3D garment model worn on the 3D body model of the user.

Abstract: Systems and methods for identifying comment clusters for panoramic content segments. A panoramic content segment of digital content may be hosted to client computing platforms. User comment information may be received. The user comment information may convey user comments, include time indications for a duration of a content segment, and/or include location indications for a panorama of the panoramic content segment. A comment distribution may be determined from the user comment information. A comment cluster may be identified based on the comment distribution. View information may be received from a client computing platform. Whether a view range associated with the comment cluster identified is located within or outside one or more visible ranges of viewing angles selected by the user may be determined. Alert information may be generated and/or transmitted for effectuating presentation of a notification on the client computing platform associated with the user.

Abstract: Systems and methods for identifying comment clusters for panoramic content segments. A panoramic content segment of digital content may be hosted to client computing platforms. User comment information may be received. The user comment information may convey user comments, include time indications for a duration of a content segment, and/or include location indications for a panorama of the panoramic content segment. A comment distribution may be determined from the user comment information. A comment cluster may be identified based on the comment distribution. View information may be received from a client computing platform. Whether a view range associated with the comment cluster identified is located within or outside one or more visible ranges of viewing angles selected by the user may be determined. Alert information may be generated and/or transmitted for effectuating presentation of a notification on the client computing platform associated with the user.

Abstract: The present invention relates to certain novel substituted thiophene compounds and the finding that they display useful efficacy in the inhibition of the p38? MAPK enzyme. This provides for use of the compounds in various treatment methodologies related to MAPK inhibition, including the treatment of inflammation.

Abstract: Systems and methods for identifying comment clusters for panoramic content segments. A panoramic content segment of digital content may be hosted to client computing platforms. User comment information may be received. The user comment information may convey user comments, include time indications for a duration of a content segment, and/or include location indications for a panorama of the panoramic content segment. A comment distribution may be determined from the user comment information. A comment cluster may be identified based on the comment distribution. View information may be received from a client computing platform. Whether a view range associated with the comment cluster identified is located within or outside one or more visible ranges of viewing angles selected by the user may be determined. Alert information may be generated and/or transmitted for effectuating presentation of a notification on the client computing platform associated with the user.

Abstract: Systems and methods for identifying comment clusters for panoramic content segments. A panoramic content segment of digital content may be hosted to client computing platforms. User comment information may be received. The user comment information may convey user comments, include time indications for a duration of a content segment, and/or include location indications for a panorama of the panoramic content segment. A comment distribution may be determined from the user comment information. A comment cluster may be identified based on the comment distribution. View information may be received from a client computing platform. Whether a view range associated with the comment cluster identified is located within or outside one or more visible ranges of viewing angles selected by the user may be determined. Alert information may be generated and/or transmitted for effectuating presentation of a notification on the client computing platform associated with the user.

Abstract: The present invention provides the tertiary structure of a Hepatitis B Virus (HBV) polymerase reverse transcriptase (rt) domain from which a variant HBV polymerase mutations associated with resistance to or having reduced sensitivity to an anti-viral drug have been mapped. The present invention further provides methods of identifying, designing and/or modifying agents capable of modulating the functional activity of the HBV polymerase based on the atomic co-ordinates provided by the tertiary structure. The present invention still further provides a method of modulating HBV polymerase functional activity and agents useful for same. The agents identified in accordance with the method of the present invention are particularly useful inter alia in the treatment and/or prophylaxis of infection by an HBV resistant to or exhibiting reduced sensitivity to an anti-viral drug. The agents may also have utility as diagnostic agents such as to distinguish between resistance mutations.