Abstract: The subject matter described herein provides systems and techniques to address the challenges of growing hardware and workload heterogeneity using a Warehouse-Scale Computer (WSC) design that improves the efficiency and utilization of WSCs. The WSC design may include an abstraction layer and an efficiency layer in the software stack of the WSC. The abstraction layer and the efficiency layer may be designed to improve job scheduling, simplify resource management, and drive hardware-software co-optimization using machine learning techniques and automation in order to customize the WSC for applications at scale. The abstraction layer may embrace platform/hardware and workload diversity through greater coordination between hardware and higher layers of the WSC software stack in the WSC design. The efficiency layer may employ machine learning techniques at scale to realize hardware/software co-optimizations as a part of the autonomous WSC design.

Abstract: Various aspects include a wearable audio device having active noise reduction (ANR). In some cases, a method for processing audio signals includes receiving a noise reduction signal configured to modify an audio signal and generate a noise reduced audio signal, the noise reduction signal having a nominal loop gain; and generating an adjusted noise reduction signal in response to a detected adverse low frequency event, the adjusted noise reduction signal having a modulated loop gain configured to reduce artifacts in the noise reduced audio signal.

Abstract: Among other things, the present disclosure provides designed APOC3 oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc.

Abstract: Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample.

Abstract: The present invention relates to compositions of peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.

Abstract: The invention provides an associative polymer, a powder, and a process for making a powder including, networking one or more associative polymers and one or more optional surfactants to form a wet gel, and forming a powder from the wet gel, wherein the associative polymer(s) have a weight average molecular weight of from about 10 kDa to about 2,000 kDa.

Abstract: An anti-fouling composition, and uses thereof in the industrial preparation of ethylenically unsaturated monomers comprising at least one heteroatom, such as acrylic monomers are disclosed.

Abstract: A composite foam article is disclosed herein. The composite foam article comprises a polyurethane foam core presenting a first surface and a second surface facing opposite the first surface. A first skin is disposed on the first surface and a second skin is disposed on the second surface. The polyurethane foam core has a density of 15-80 kg/m3. The first and second skins comprise a plurality of fibers and a polymeric binder. The composite foam article has a weight per unit area of 500-1000 g/m2 and a strength of greater than 17 N at a post-compression thickness of greater than 2 mm when tested in according with SAE J949 at 23° C.

Abstract: Compositions and colloidal particles are provided that may be used to improve a papermaking process. The compositions and colloidal particles may include a polymer and an inorganic salt. A papermaking process carried out using the presently disclosed compositions and colloidal particles may produce a paper product that has increased strength properties.

Abstract: Methods and apparatus for modulating light using a tunable light modulation device. The tunable light modulation devices comprises an elastomer structure including at least one elastomer layer, a compliant electrode network of conducting fibers arranged on a first surface of the at least one elastomer layer, a patterned electric conductor arranged on a second surface of the at least one elastomer layer opposite the first surface. The patterned electric conductor includes a plurality of individually-addressable sections, and the compliant electrode network is configured to compress the at least one elastomer layer in the presence of an electric field between the compliant electrode network and one or more of the individually-addressable sections of the patterned electric conductor to produce a voltage-dependent roughening of the at least one elastomer layer.

Abstract: Disclosed herein are implantable devices coated with a reagent, and methods of preparing and utilizing such devices. The implantable device may comprise an implantable light conduit. The present disclosure enables a more precise registration between the reagent and the device implanted in the target tissue of a subject.

Abstract: A system and method for an automatic transfer switch comprising a fixed contact, a first oscillating rod communicatively and operatively connected to a first movable contact, a second oscillating rod communicatively and operatively connected to a second movable contact, a link rod communicatively and operable connected to the first and second oscillating rods, and a guide plate. The automatic transfer switch is operable to position the guide plate based at least on a state of a solenoid. A permanent magnetic actuator communicatively and operatively connected to the link rod via a third oscillating rod is operable to rotate the first oscillating rod or the second oscillating rod based at least on the position of the guide plate.

Abstract: Crucible for growing single crystals, formed from W, Mo, Re, an alloy or a base alloy of these metals, and a process for producing a crucible (2), wherein at least part of an outwardly facing outer face (4) of the crucible (2) has, at least in certain regions, a profile with a mean profile depth (a) of between 5 and 500 ?m.

Abstract: A system and method for an automatic transfer switch comprising a fixed contact, a first oscillating rod communicatively and operatively connected to a first movable contact, a second oscillating rod communicatively and operatively connected to a second movable contact, a link rod communicatively and operable connected to the first and second oscillating rods, and a guide plate. The automatic transfer switch is operable to position the guide plate based at least on a state of a solenoid. A permanent magnetic actuator communicatively and operatively connected to the link rod via a third oscillating rod is operable to rotate the first oscillating rod or the second oscillating rod based at least on the position of the guide plate.

Abstract: A facility procuring information about a distinguished property from its owner that is usable to refine an automatic valuation of the distinguished property is described. The facility displays information about the distinguished property used in the automatic valuation of the distinguished property. The facility obtains user input from the owner adjusting at least one aspect of information about the distinguished property used in the automatic valuation of the distinguished property. The facility then displays to the owner a refined valuation of the distinguished property that is based on the adjustment of the obtained user input.

Abstract: The device described herein includes self-adhering graphics presented in a multiple perspectives so that when applied to structural containers, such as cardboard boxes, the containers are transformed, child playthings.

Abstract: Systems and techniques to allow a user to design and manage business solutions. The business solution management system (150) comprises a portal layer (112), an application layer (104) and a data repository (106). The portal layer (112) comprises at least first and second agents (204, 208). The application layer (104) comprises at least first and second software applications (220, 224). The first and second agents (204, 208) provide user interfaces to the first and second software applications (220, 224). The first software application (220) is operable to allow a user to design a business solution with user parameters and user-selectable, pre-defined business process objects and pre-defined technology objects. The second software application (224) is operable to allow a user to manage the business solution. The data repository (106) comprises the pre-defined business objects (316) and pre-defined technology objects (314).

Abstract: A modular wheelchair assembly is adapted to be reconfigured between a fixed angle of tilt, a dynamically adjustable tilt-in-space configuration with the tilt axis being near the user's knees and a dynamically adjustable tilt-in-space configuration with the tilt axis being near the user's center of gravity. The reconfiguration is achieved by modifying a limited number of selectively removable components of the support assembly or the pivot assembly of the wheelchair.

Abstract: A modular wheelchair assembly is adapted to be reconfigured between a fixed angle of tilt, a dynamically adjustable tilt-in-space configuration with the tilt axis being near the user's knees and a dynamically adjustable tilt-in-space configuration with the tilt axis being near the user's center of gravity. The reconfiguration is achieved by modifying a limited number of selectively removable components of the support assembly or the pivot assembly of the wheelchair.

Abstract: A telescoping crossbar assembly for a wheelchair comprises an inner tube that is slidable within an outer tube. The head portion of a pass-through fastener bears on the inner tube through a sufficiently large head-side aperture so as to slightly deform the inner tube and to hold the two tubes by friction in mutual engagement.