Patents by Inventor David Chien

David Chien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic reagents from west nile virus
    Patent number: 8475808
    Abstract: Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: July 2, 2013
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: William Andrews, David Chien, Qui-Lim Choo, Stephen Coates, Doris Coit, Charles Harrington, Susan Hilt, Michael Houghton, Angelica Medina-Selby, Sergio Pichuantes, Yiu-Lian Fong
  • HCV multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof
    Patent number: 7871625
    Abstract: Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV immunoassays including the modified MEFAs are also described.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: January 18, 2011
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Chien, Doris Coit, Carlos George-Nascimento, Sansan Lin, Angelica Medina-Selby, Laura Tandeske
  • Elisa assays using prion-specific peptide reagents
    Publication number: 20090130774
    Abstract: Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described for use in detecting PrPsc in biological samples. In particular, ELISA assays are described.
    Type: Application
    Filed: January 13, 2006
    Publication date: May 21, 2009
    Inventors: David Peretz, Melissa Michelitsch, Celine Hu, Xuemei Wang, Man Gao, Michael Connolly, Thomas Horn, Ronald Zuckermann, David Chien
  • Isolation of pathogenic prions
    Publication number: 20090099343
    Abstract: Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described. Methods of using the reagents for isolation and purification of the PrPsc isoform are described.
    Type: Application
    Filed: January 13, 2006
    Publication date: April 16, 2009
    Inventors: David Peretz, Melissa Michelitsch, Celine Hu, David Chien, John Hall, Xuemei Wang, Man Gao
  • HCV non-structural protein mutants and uses thereof
    Patent number: 7491808
    Abstract: Modified HCV non-structural proteins are described. The proteins include modified NS3 domains such that proteolytic activity of the NS3 molecule is inhibited. The modified proteins retain conformational epitopes. HCV immunoassays including the modified NS3 molecules are also described.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: February 17, 2009
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Chien, Doris Coit, Celine Hu, Sansan Lin, Angelica Medina-Selby
  • Intracellular production of hepatitis C E1 and E2 truncated polypeptides
    Patent number: 7429385
    Abstract: Methods for obtaining recombinantly produced, C-terminally truncated, E1 and E2 polypeptides from cell lysates are disclosed. The intracellularly expressed truncated molecules display improved biological properties as compared to their secreted counterparts.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: September 30, 2008
    Assignee: Novartis Vaccines & Diagnostics
    Inventors: Michael Houghton, Qui-Lim Choo, Sergio Abrignani, David Chien, Mark Selby, Edward Glazer
  • CD40-related receptor that binds CD40L
    Patent number: 7378492
    Abstract: Various embodiments of the invention provide human receptors and membrane-associated proteins (REMAP) and Q polynucleotides which identify and encode REMAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REMAP.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: May 27, 2008
    Assignee: Incyte Corporation
    Inventors: Narinder K. Chawla, Henry Yue, Thomas W. Richardson, Joseph P. Marquis, Patricia M. Lehr-Mason, Ann E. Gorvad, Shanya D. Becha, Amy E. Kable, Anita Swarnakar, Pei Jin, Phillip R. Hawkins, David Chien, Jayalaxmi Ramkumar, Uyen K. Tran, April J. A. Hafalia, Mariah R. Baughn, Soo Yeun Lee, Xin Jiang, Alan A. Jackson, Reena Khare, Sean A. Bulloch
  • Cell adhesion and extracellular matrix proteins
    Publication number: 20070276126
    Abstract: Various embodiments of the invention provide human cell adhesion and extracellular matrix proteins (CADECM) and polynucleotides which identify and encode CADECM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CADECM.
    Type: Application
    Filed: August 12, 2003
    Publication date: November 29, 2007
    Inventors: Vicki Elliott, Reena Khare, Brooke Emerling, Amy Kable, Uyen Tran, Pei Jin, Shanya Becha, Joseph Marquis, Anita Swarnakar, Narinder Chawla, Jayalaxmi Ramkumar, April Hafalia, Soo Lee, Xin Jiang, Alan Jackson, Thomas Richardson, Julie Blake, Jonathan Wang, David Chien, Yonghong Yang
  • ROLLING WALKER
    Publication number: 20070235067
    Abstract: A rolling walker includes a collapsible frame, a pair of upwardly extending push arms coupled to an upper portion of the frame, and at least one pair of wheel units coupled to a lower portion of the frame. The collapsible frame is configured for movement between an unfolded use position and a folded storage position.
    Type: Application
    Filed: March 30, 2006
    Publication date: October 11, 2007
    Applicant: Cosco Management, Inc.
    Inventors: Bradley Gale, Joshua Trimble, David Chien, Sean Ho
  • Immunogenic reagents from west nile virus
    Publication number: 20070092538
    Abstract: Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
    Type: Application
    Filed: May 21, 2004
    Publication date: April 26, 2007
    Inventors: William Andrews, David Chien, Qui-Lim Choo, Stephen Coates, Doris Coit, Charles Harrington, Susan Hilt, Michael Houghton, Angelica Medina-Selby, Sergio Pichuantes
  • HCV assay
    Patent number: 7166426
    Abstract: An HCV antigen/antibody/antigen assay is provided. The assay employs an isolated first antigen from a region of the HCV polyprotein, and an HCV multiple epitope fusion antigen that includes an epitope from the same region of the polyprotein as the first antigen. Both the first antigen and the multiple epitope fusion antigen bind antibodies present in an HCV-infected sample.
    Type: Grant
    Filed: September 8, 2003
    Date of Patent: January 23, 2007
    Assignee: Novartis Vaccines And Diagnostics, Inc.
    Inventors: Phillip Arcangel, David Chien
  • Immune response-associated proteins
    Publication number: 20070009516
    Abstract: Various embodiments of the invention provide human immune response associated proteins (IRAP) and polynucleotides which identify and encode IRAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of IRAP.
    Type: Application
    Filed: November 25, 2003
    Publication date: January 11, 2007
    Inventors: Uyen Tran, Thomas Richardson, Shanya Becha, Vicki Elliott, Anita Swarnakar, Soo Lee, Jayalaxmi Ramkumar, Jonathan Wang, David Chien, Jagi Murage, Mili Gera, Joseph Marquis, Narinder Chawla, Lisa Nakamura, Amy Kable
  • Protease regulator screening assay
    Publication number: 20060292659
    Abstract: A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.
    Type: Application
    Filed: August 1, 2005
    Publication date: December 28, 2006
    Applicant: Chiron Corporation
    Inventors: David Chien, Mark Selby, Kevin Shoemaker, Robert Warne
  • Severe acute respiratory syndrome coronavirus
    Publication number: 20060257852
    Abstract: An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.
    Type: Application
    Filed: April 9, 2004
    Publication date: November 16, 2006
    Applicant: Chiron Corporation
    Inventors: Rino Rappuoli, Vega Masignani, Konrad Stadler, Jens Gregersen, David Chien, Jang Han, John Polo, Amy Weiner, Michael Houghton, Hyun Song, Mi-Young Seo, John Donnelly, Hans Klenk, Nicholas Valiante
  • Receptors and membrane-associated proteins
    Publication number: 20060121459
    Abstract: Various embodiments of the invention provide human receptors and membrane-associated proteins (REMAP) and Q polynucleotides which identify and encode REMAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REMAP.
    Type: Application
    Filed: February 18, 2003
    Publication date: June 8, 2006
    Inventors: Narinder Chawla, Henry Yue, Thomas Richardson, Joseph Marquis, Patricia Lehr-Mason, Ann Gorvad, Shanya Becha, Amy Kable, Anita Swarnakar, Pei Jin, Phillip Hawkins, David Chien, Jayalaxmi Ramkumar, Uyen Tran, April Hafalia, Mariah Baughn, Soo Lee, Xin Jiang, Alan Jackson, Reena Khare, Sean Bulloch
  • HCV non-structural protein mutants and uses thereof
    Publication number: 20060051745
    Abstract: Modified HCV non-structural proteins are described. The proteins include modified NS3 domains such that proteolytic activity of the NS3 molecule is inhibited. The modified proteins retain conformational epitopes. HCV immunoassays including the modified NS3 molecules are also described.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 9, 2006
    Applicant: Chiron Corporation
    Inventors: David Chien, Doris Coit, Celine Hu, Sansan Lin, Angelica Medina-Selby
  • Rabbit monoclonal antibodies to hepatitis B surface antigens and methods of using the same
    Publication number: 20060008798
    Abstract: Reagents, methods and immunodiagnostic test kits for the accurate detection of hepatitis B virus (HBV) infection are disclosed. The methods and kits employ novel rabbit monoclonal antibodies directed against HBV surface antigens (HBsAg) with mutations in the “a” determinant region of HBsAg.
    Type: Application
    Filed: June 7, 2005
    Publication date: January 12, 2006
    Inventors: David Chien, Yiu-Lian Fong, Azita Tabrizi, Heather Todd, Mark Van Cleve
  • Device and method for in-line blood testing using biochips
    Publication number: 20050048519
    Abstract: A device for in-line blood screening and testing using biochips is disclosed. The screening methods include nucleic acid amplification techniques and antibody/antigen assays to detect target molecules and agents indicative of infectious diseases or metabolic diseases.
    Type: Application
    Filed: December 12, 2003
    Publication date: March 3, 2005
    Inventors: David Chien, Bruce Phelps
  • Biological sample storage device and method for biological sample contamination testing
    Publication number: 20040209353
    Abstract: The present invention is directed to a method for screening blood and blood products that utilizes a specialized blood and blood products storage device useful for storing and testing blood or blood products comprising a container having at least one compartment with one or more sections for storing and testing the blood or blood products for a target molecule. The method utilizes a homogeneous testing system that employs ribozymes, DNAzymes or catalytic antibodies.
    Type: Application
    Filed: December 12, 2003
    Publication date: October 21, 2004
    Applicant: Chiron Corporation
    Inventors: David Chien, Bruce H. Phelps
  • Kinases and phosphatases
    Publication number: 20040203097
    Abstract: The invention provides human kinases and phosphatases (KPP) and polynucleotides which identify and encode KPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.
    Type: Application
    Filed: November 18, 2003
    Publication date: October 14, 2004
    Inventors: Henry Yue, Dyung Aina M Lu, Yalda Azimzai, Li Ding, Ernestine A Lee, April J A Hafalia, Shanya D Becha, Y Tom Tang, Preeti G. Lal, Jennifer A Griffin, Rajagopal Gururajan, Jayalaxmi Ramkumar, Vicki S Elliott, Chandra S Arvizu, Wen Luo, Anita Swarnakar, Brendan M Duggan, Uyen K Tran, Narinder K Chawla, Ameena E Gandhi, Monique G Yao, Farrah A Khan, Mariah R Baughn, Mark L Borowsky, Yeganeh Zebarjadian, Thomas W Richardson, Joseph P Marquis, David Chien, Pei Jin