Abstract: The invention relates to novel heteroaryl compounds of Formula (I), and pharmaceutically acceptable salts thereof; and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cardiovascular diseases, and methods treating sepsis or septic shock, using the novel heterocyclic compounds disclosed herein.

Abstract: The present invention relates to compounds of Formula (I) that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: wherein R1, R2, R3, R4, R6 and R10 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which MLH1 and/or PMS2 activity is implicated.

Abstract: Systems and methods for prescribing athletic activity to be performed by a user, and for adapting the prescribed athletic activity based on completed (e.g. ongoing) athletic performances by the user. A coaching plan may be automatically created that prescribes personalized athletic activities as a user trains towards a goal date. The athletic information may be received from one or more sensor devices associated with a user, and the coaching plan may be continuously or intermittently updated based on the received sensor data.

Abstract: A system for regenerating ion exchange resin can include a vehicle, a tank coupled to the vehicle and configured to supply brine and receive waste solution, a pump fluidly coupled to the tank and configured to be fluidly coupled to an ion exchange resin of an ion exchange column, a control system configured to control the pump, and one or more sensors configured to measure properties of the brine and/or waste solution and provide data to the control system. The one or more sensors can include a conductivity meter configured to measure the conductivity of the waste solution. The pump can supply brine which is configured to regenerate the ion exchange resin by removing one or more impurities from the ion exchange resin of the ion exchange column. The control system can collect data and use it to adjust system operation.

Abstract: Aspects relate to systems, methods, and apparatuses relating to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: Systems and methods for prescribing athletic activity to be performed by a user, and for adapting the prescribed athletic activity based on completed (e.g. ongoing) athletic performances by the user. A coaching plan may be automatically created that prescribes personalized athletic activities as a user trains towards a goal date. The athletic information may be received from one or more sensor devices associated with a user, and the coaching plan may be continuously or intermittently updated based on the received sensor data.

Abstract: A bushing system for use in a magnetic drive or canned motor pump, the system comprising: a bush holder having an axial recess for receiving a bush, a bush for insertion into the axial recess, the bush and bush holder each having: one or more cooperating features which abut against each other when the bush is fitted into the recess; and a recess for receiving at least part of a retention member; wherein, when the cooperating features abut, the retention member recesses on the bush holder and the bush are axially offset.

Abstract: In some embodiments, an electronic device performs techniques related to displaying personalized workout suggestions based on completed workouts. In some embodiments, an electronic device performs techniques related to starting an audio-based workout. In some embodiments, an electronic device performs techniques related to displaying information about a workout during playback of workout content. In some embodiments, an electronic device performs techniques related to displaying information about physical activity of a user relative to a group of users. In some embodiments, an electronic device performs techniques related to coordinating display of workout content among multiple devices.

Abstract: In one example, an electronic device comprises a substrate comprising a dielectric structure and a conductive structure, a first electronic component over a top side of the substrate and comprising a first transceiver, wherein the first electronic component is coupled to the conductive structure, a second electronic component coupled to the substrate and the conductive structure and comprising a second transceiver, an encapsulant over the top side of the substrate and defining a cavity, wherein the second transceiver is in the cavity and the first electronic component is covered by the encapsulant, and a lid over the top side of the substrate and covering the second electronic component. Other examples and related methods are also disclosed herein.

Abstract: In various examples, users may access a tool that automatically generates video montages from video clips of the user's gameplay according to parameterized recipes. As a result, a user may select—or allow the system to select—clips corresponding to gameplay of the user and customize one or more parameters (e.g., transitions, music, audio, graphics, etc.) of a recipe, and a video montage may be generated automatically according to a montage script output using the recipe. As such, a user may have a video montage generated with little user involvement, and without requiring any skill or expertise in video editing software. In addition, even for experienced video editors, automatic video montage generation may be a useful alternative to save the time and effort of manually curating video montages.

Abstract: A technique facilitates deployment and use of a seal rotating system without retrieving the running tool prior to a drilling operation. The running tool remains with the drill string after deployment of the seal rotating system which saves substantial time by avoiding retrieval of the running tool prior to conducting the drilling operation. According to an embodiment, a seal rotating system is mounted to the running tool and the running tool is connected into a drill string. The running tool is used to position the seal rotating system in a rotating control device housing which may be positioned along, for example, a riser. The running tool is then released from the seal rotating system and is moved downhole as part of the drill string to enable performance of a borehole drilling operation without removing the running tool.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: In various examples, users may access a tool that automatically generates video montages from video clips of the user's gameplay according to parameterized recipes. As a result, a user may select—or allow the system to select—clips corresponding to gameplay of the user and customize one or more parameters (e.g., transitions, music, audio, graphics, etc.) of a recipe, and a video montage may be generated automatically according to a montage script output using the recipe. As such, a user may have a video montage generated with little user involvement, and without requiring any skill or expertise in video editing software. In addition, even for experienced video editors, automatic video montage generation may be a useful alternative to save the time and effort of manually curating video montages.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: Systems and methods for prescribing athletic activity to be performed by a user, and for adapting the prescribed athletic activity based on completed (e.g. ongoing) athletic performances by the user. A coaching plan may be automatically created that prescribes personalized athletic activities as a user trains towards a goal date. The athletic information may be received from one or more sensor devices associated with a user, and the coaching plan may be continuously or intermittently updated based on the received sensor data.

Abstract: An assembly for offsite construction of a building, a connector for use in such an assembly, along with a method of manufacture of such a connector, and a method of construction using the assembly. The connector includes first and second buttress elements defining, respectively, a first location portion and a second location portion. The first location portion and the second location portion are configured, respectively, to receive first and second structural elements extending at transverse angles to each other. The first and second buttress elements each has first and second opposite side walls defining an access space between them for a connector to be accessed. The second side wall of the first buttress element and the second side wall of the second buttress element together define a third location portion configured to receive a third structural element extending transversely to the first and second structural elements.

Abstract: The present invention relates to compounds of Formula (II) that target the PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: wherein R2, R4, R6, Y1, Y2, A1, A2, A3, and A4 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PMS2 activity is implicated.

Abstract: The present invention relates to compounds of Formula (I) that target PMS2, a component of DNA Mismatch Repair (MMR): wherein R2, R4, R6, A1, A2, A4, L and Q are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PMS2 is implicated.

Abstract: In some embodiments, an electronic device performs techniques related to displaying personalized workout suggestions based on completed workouts. In some embodiments, an electronic device performs techniques related to starting an audio-based workout. In some embodiments, an electronic device performs techniques related to displaying information about a workout during playback of workout content. In some embodiments, an electronic device performs techniques related to displaying information about physical activity of a user relative to a group of users. In some embodiments, an electronic device performs techniques related to coordinating display of workout content among multiple devices.