Abstract: The present invention relates to boron containing compounds of Formula (I) X—Y—Z ??Formula (I) that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

Abstract: The present invention relates to boron containing compounds of Formula (IA): that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

Abstract: A dipole antenna apparatus, and method of manufacture of such an apparatus, are provided. The antenna apparatus has a conductive plate extending in a first plane, and a pair of conductive elements arranged to form a dipole antenna, where the pair of conductive elements are located in a second plane parallel to the first plane. Each conductive element forms a conductive ring in the second plane that surrounds a non-conductive inner area. The first conductive element in the pair of conductive elements has a conductive bridge extending across the conductive ring to divide the non-conductive inner area into at least two portions. A conductive connection then extends from the conductive bridge to the conductive plate.

Abstract: A dipole antenna apparatus, and method of manufacture of such an apparatus, are provided. The antenna apparatus has a conductive plate extending in a first plane, and a pair of conductive elements arranged to form a dipole antenna, where the pair of conductive elements are located in a second plane parallel to the first plane. Each conductive element forms a conductive ring in the second plane that surrounds a non-conductive inner area. The first conductive element in the pair of conductive elements has a conductive bridge extending across the conductive ring to divide the non-conductive inner area into at least two portions. A conductive connection then extends from the conductive bridge to the conductive plate.

Abstract: The present invention relates to PDE4 inhibitor (R)-4-(5-(4-methoxy-3-propoxyphenyl)pyridin-3-yl)-1,2-oxaborolan-2-ol including the crystalline monohydrate thereof.

Abstract: The present invention relates to boron containing compounds of Formula (I) X—Y—Z?? Formula (I) that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

Abstract: An apparatus and method for loading ammunition magazines that allows for loading in an efficient and fast manner, proper storage of ammunition and limited, if any, contact between the user and the lead coating of the ammunition. The apparatus relieves thumb fatigue and blisters due to the circular indent that depresses the button on the magazine. The apparatus is also designed to prevent fouling because of the lack of contact between the wax and residue of the bullet and the mechanical device.

Abstract: The present invention relates to boron containing compounds of Formula (I) X—Y—Z?? Formula (I) that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

Abstract: An apparatus and method for loading ammunition magazines that allows for loading in an efficient and fast manner, proper storage of ammunition and limited, if any, contact between the user and the lead coating of the ammunition. The apparatus relieves thumb fatigue and blisters due to the circular indent that depresses the button on the magazine. The apparatus is also designed to prevent fouling because of the lack of contact between the wax and residue of the bullet and the mechanical device.

Abstract: An article tracking system including: a plurality of tags, each tag being attached to a respective article in use and including: a power supply; a tag transceiver that transmits or receives messages; and a tag processing device; a number of tag readers, each tag reader including: at least one reader transceiver that transmits or receives messages; and, a reader processing device in communication with the at least one tag reader; and, at least one processing system in communication with the number of tag readers, and wherein in use each tag reader: generates a message; and, transmits the message to one or more tags within an operating range of the reader, wherein ones of the one or more tags in a passive operating mode are responsive to the message to: receive the message; selectively change a tag operating mode; and, if the message is a broadcast message, transmit a tag message at least partially indicative of an identity of the tag; receives any tag messages; generates location data at least partially indica

Abstract: A preferred form of the invention relates to the field of orthopaedic medicine, and in particular to a means for quickly and easily achieving the desired position of the ring of an external fixator frame relative to the lens of an x-ray machine. A particularly preferred form of the invention relates to a device to assist radiographers in obtaining the desired alignment of external fixator frame rings in relation to the lens of an x-ray machine.

Abstract: An object monitoring system, including a slave system having slave processors (14, 16) and a plurality of cameras (10) for monitoring one or more objects, images of the cameras (10) being processed by respective ones of the slave processor (14, 16), and the slave processors including sensors (30) assigned to respective cameras (10) and at least parts of the fields of view of the cameras (10) to detect predetermined characteristics of the at least parts and generate a trigger in response thereto. A master system has to master processor (20) including agents (34) assigned to at least one of the objects and having one or more of the sensors (30) allocated thereto, the agents (34) each generating an event on receiving triggers from the one or more allocated sensors (30). An event system (6) receives the events and determines whether an alarm condition exists. A user interface system (8) can configure the sensors (30) and agents (34) and respond to events.

Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, Het and m are as defined in the description. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors.

Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, m and n are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.

Abstract: A method is provided for making an enantiomerically pure compound of the formula: in which R and R? represent C1?C10 alkyl, C2?C10 alkenyl or C3?C10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conjugate addition is carried out between an organometallic nucleophile that provides a group R as defined above and (R)-4-acetoxycyclopent-2-en-1-one, (S)-4-acetoxycyclopent-2-en-1-one or a similar compound in which acetoxy is replaced by another leaving group to give, e.g.

Abstract: The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize steroselectively analogs of gabapentin (Neurontin®) of Formulas (I), (II), (III) and (IV) wherein R is C1-C10 alkyl or C3-C10 cycloalkyl and pharmaceutically acceptable salts thereof.

Abstract: The compounds of the instant invention are bicyclic amino acids useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathological disorders, and sleep disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.

Abstract: The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these compounds and to their use as anti-tumour agents.

Abstract: The compounds of the instant invention are bicyclic amino acids useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathological disorders, and sleep disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.