Patents by Inventor David Coffen

David Coffen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
    Publication number: 20070225362
    Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
    Type: Application
    Filed: March 5, 2007
    Publication date: September 27, 2007
    Inventors: Alan Snow, Beth Nguyen, Gerardo Castillo, Virginia Sanders, Thomas Lake, Lesley Larsen, Rex Weavers, Stephen Lorimer, David Larsen, David Coffen, Charlotte Coffen
  • Lasalocid derivatives
    Patent number: 4247690
    Abstract: There is presented compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of aryl, substituted aryl, aralkyl, heteroaryl, cycloalkyl, lower alkyl, lower alkenyl, carboxy lower alkyl, carboalkoxy lower alkyl, aminoalkyl, substituted aminoalkyl, hydroxyalkyl, alkoxy alkyl, thioalkoxy alkyl and hydrogen.These compounds exhibit pharmacological activity as antihypertensive agents.Also presented are novel intermediates leading to the end products and a process to produce the end products.
    Type: Grant
    Filed: October 1, 1979
    Date of Patent: January 27, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventor: David Coffen
  • Lasalocid derivatives
    Patent number: 4193928
    Abstract: There is presented compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of aryl, substituted aryl, aralkyl, heteroaryl, cycloalkyl, lower alkyl, lower alkenyl, carboxy lower alkyl, carboalkoxy lower alkyl, aminoalkyl, substituted aminoalkyl, hydroxyalkyl, alkoxy alkyl, thioalkoxy alkyl and hydrogen.These compounds exhibit pharmacological activity as antihypertensive agents.Also presented are novel intermediates leading to the end products and a process to produce the end products.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: March 18, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: David Coffen