Abstract: The invention provides compositions and methods for use in the treatment and prevention of cholestatic diseases.

Abstract: A locking mechanism includes a pin configured to movably couple to a first element of an agricultural header, wherein the first element includes one of an arm and a frame. The locking mechanism also includes a mount configured to couple to a second element of the agricultural header, wherein the second element includes the other of the arm and the frame. The pin is disposed within an opening of the mount, the opening has a first portion configured to receive the pin while the pin is in a first position and to block relative movement between the pin and the mount to block rotation of the arm, and the opening has a second portion configured to receive the pin while the pin is in a second position and to enable relative movement between the pin and the mount to enable rotation of the arm.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: An apparatus for multi-stage fracking, wherein the apparatus includes a pump configured to pump a fracking fluid into a rock region comprises a plurality of rock zones, and a computing device communicatively connected to the pump, wherein the computing device includes at least a processor, and a memory communicatively connected to the at least a processor containing instructions configuring the at least a processor to receive reservoir data, determine an optimal fracking stimulation parameter as a function of the reservoir data, identify a fracking stage as a function of the optimal fracking stimulation parameter, and adjust a pump configuration of the pump as a function of the fracking stage.

Abstract: At least one processing device, operating upon a body of text in a document, identifies occurrences of at least one content type in the body of text. The at least one processing device thereafter generates a user interface that includes portions of text from the body of text that are representative of at least some of the occurrences of the at least one content type in the document. For each content type, the occurrences corresponding to that content type can be grouped together to provide grouped content type occurrences that are subsequently collocated in the user interface. Those portions of text corresponding to the grouped content type occurrences may be arranged in alphanumeric order. The user interface may comprise at least a portion of the body of text as well as indicia indicating instances of the occurrences within the portion of the body of text.

Abstract: Described is a power transmission gate which includes a charge pump, an NMOS transistor, and a gate driver circuit configured to power (or bias or “drive”) a gate of the NMOS transistor. With this arrangement, a power transmission gate capable of achieving substantially the same resistance provided by prior art power transmission gates while having a footprint of just over one NMOS size unit is provided.

Abstract: In an aspect, an apparatus for predicting downhole conditions is disclosed. The apparatus comprises at least a processor and a memory communicatively connected to the at least a processor. The memory containing instructions configuring the at least a processor to receive a condition datum. The memory additionally contains instructions configuring the at least a processor to produce a measured downhole condition using at least a sensor. The memory instructs the processor to convert the condition datum and the measured downhole conditions into a cleansed data format using a data conversion module. The processor is instructed by the memory to identify a flagged data as a function of the cleansed condition datum and the cleansed measured downhole conditions using a downhole machine learning model. The memory instructs the processor to generate a predicted downhole condition as a function of the flagged data.

Abstract: An apparatus for generating a digital assistant is disclosed. The apparatus include at least a processor and a memory communicatively connected to the at least a processor. The memory instructs the processor to receive at least one user query from a user. The memory instructs the processor to extract a plurality of background data and a plurality of contextual data from the user dataset. The memory instructs the processor to receive at least one user query from a user. The memory instructs the processor to generate a query response as a function of the at least one user query and the contextual data using the digital assistant. The memory instructs the processor to display the query response using the digital assistant on a display device.

Abstract: An apparatus and method for fracking optimization, wherein the apparatus includes at least a processor, and a memory, wherein the memory containing instructions configuring the at least a processor to receive a reservoir datum from at least a sensing device, generate a production training data include a plurality of reservoir datums as input correlated to a plurality of optimal production parameters as output, train a fracking optimization machine-learning model using the production training data, determine an optimal production parameter as a function of the fracking optimization machine-learning model, and generating an optimal production plan as a function of the optimal production parameter.

Abstract: An apparatus and method for fracking optimization, wherein the apparatus includes at least a processor, and a memory, wherein the memory containing instructions configuring the at least a processor to receive a reservoir datum from at least a sensing device, generate a production training data include a plurality of reservoir datums as input correlated to a plurality of optimal production parameters as output, train a fracking optimization machine-learning model using the production training data, determine an optimal production parameter as a function of the fracking optimization machine-learning model, and generating an optimal production plan as a function of the optimal production parameter.

Abstract: A compromised data exchange system extracts data from websites using a crawler, detects portions within the extracted data that resemble personally identifying information (PII) data based on PII data patterns using a risk assessment module, and compares a detected portion to data within a database of disassociated compromised PII data to determine a match using the risk assessment module. A risk score may be assigned to a data item within the database in response to determining the match. In some embodiments, URL data may also be detected in the extracted data. The detected URL data represents further websites that can be automatically crawled by the system to detect further PII data.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: An apparatus for multi-stage fracking, wherein the apparatus includes a pump configured to pump a fracking fluid into a rock region comprises a plurality of rock zones, and a computing device communicatively connected to the pump, wherein the computing device includes at least a processor, and a memory communicatively connected to the at least a processor containing instructions configuring the at least a processor to receive reservoir data, determine an optimal fracking stimulation parameter as a function of the reservoir data, identify a fracking stage as a function of the optimal fracking stimulation parameter, and adjust a pump configuration of the pump as a function of the fracking stage.

Abstract: A ladar system capable of operating in a ladar mode and an optical communication mode is disclosed. When operating in the ladar mode, a ladar transmitter and ladar receiver cooperate to transmit ladar pulses that are used for ranging to targets in a field of view. When operating in an optical communication mode, ladar pulses are used to transmit data messages to locations in the field of view that are determined to have devices that are capable of receiving the optically communicated data messages.

Abstract: An apparatus and method for generating a compiled artificial intelligence (AI) model. The apparatus incudes a processor that is configured to receive data sets from user devices. The processor is further configured to convert the data sets using a machine-learning model into a cleansed data format and generate an accumulated model using the converted data sets as training data.

Abstract: Disclosed herein is a compact beam scanner assembly that includes an ellipsoidal reimaging mirror.

Abstract: Disclosed herein are a number of example embodiments that employ controllable delays between successive ladar pulses in order to discriminate between “own” ladar pulse reflections and “interfering” ladar pulses reflections by a receiver. Example embodiments include designs where a sparse delay sum circuit is used at the receiver and where a funnel filter is used at the receiver. Also, disclosed are techniques for selecting codes to use for the controllable delays as well as techniques for identifying and tracking interfering ladar pulses and their corresponding delay codes. The use of a ladar system with pulse deconfliction is also disclosed as part of an optical data communication system.

Abstract: Due to the factors such as lens distortion and camera misalignment, stereoscopic image pairs often contain vertical disparities. Introduced herein is a method and apparatus that determine and correct vertical disparities in stereoscopic image pairs using an optical flow map. Instead of discarding vertical motion vectors of the optical flow map, the introduced concept extracts and analyzes the vertical motion vectors from the optical flow map and vertically aligns the images using the vertical disparity determined from the vertical motion vectors. The introduced concept recognizes that although not apparent, vertical motion does exist in stereoscopic images and can be used to correct the vertical disparity in stereoscopic images.