Abstract: The invention relates to a method for auto-configuring a wavelength selective switch (WSS) device having an output port and a plurality of input ports and coupled to a WSS controller. When connected to a WDM optical network, the WSS controller is programmed to utilize one or more optical channel monitors (OCM) coupled to the input and/or output ports to detect which of the wavelengths are present at the input ports. Wavelengths that are not detected on any input port are blocked by the WSS. Any wavelength detected as present at one and only one input port is switched by the WSS to the output port. If a wavelength is detected at two or more input ports, it is either blocked by the WSS at each of the input ports until user intervention, or is blocked at all but one of the input ports as defined by assigned port priorities.

Abstract: The invention relates to a method for auto-configuring a wavelength selective switch (WSS) device having an output port and a plurality of input ports and coupled to a WSS controller. When connected to a WDM optical network, the WSS controller is programmed to utilize one or more optical channel monitors (OCM) coupled to the input and/or output ports to detect which of the wavelengths are present at the input ports. Wavelengths that are not detected on any input port are blocked by the WSS. Any wavelength detected as present at one and only one input port is switched by the WSS to the output port. If a wavelength is detected at two or more input ports, it is either blocked by the WSS at each of the input ports until user intervention, or is blocked at all but one of the input ports as defined by assigned port priorities.

Abstract: The invention relates to a method for auto-configuring a wavelength selective switch (WSS) device having an output port and a plurality of input ports and coupled to a WSS controller. When connected to a WDM optical network, the WSS controller is programmed to utilize one or more optical channel monitors (OCM) coupled to the input and/or output ports to detect which of the wavelengths are present at the input ports. Wavelengths that are not detected on any input port are blocked by the WSS. Any wavelength detected as present at one and only one input port is switched by the WSS to the output port. If a wavelength is detected at two or more input ports, it is either blocked by the WSS at each of the input ports until user intervention, or is blocked at all but one of the input ports as defined by assigned port priorities.

Abstract: The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are specifically associated with the DNA encoding them through non-covalent protein:DNA binding. The method describes ways of making the library itself, DNA molecules encoding the library and uses of the expression library.

Abstract: A method is selects membrane-translocating peptides (MTPs) from a peptide display library that are capable of crossing or penetrating a lipid membrane. A plurality of nucleic acid constructs that encode displayed peptides are expressed, resulting in the formation of a plurality of nucleic acid-peptide complexes, each complex comprising at least one displayed peptide associated with the corresponding nucleic acid construct encoding the displayed peptide; the complexes are exposed to a population of membrane-encapsulated compartments, allowing a translocating reaction to occur; complexes that remain unassociated with the membrane are removed; optionally complexes that are associated with the membrane are removed; and internalized nucleic acid-peptide complexes are recovered. The membrane-encapsulated compartments may be artificial vesicles such as liposomes, or populations of one or more cell types.

Abstract: The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are specifically associated with the DNA encoding them through non-covalent protein:DNA binding. The method describes ways of making the library itself, DNA molecules encoding the library and uses of the expression library.

Abstract: The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are specifically associated with the DNA encoding them through non-covalent protein:DNA binding. The method describes ways of making the library itself, DNA molecules encoding the library and uses of the expression library.

Abstract: The invention relates to a method for auto-configuring a wavelength selective switch (WSS) device having an output port and a plurality of input ports and coupled to a WSS controller. When connected to a WDM optical network, the WSS controller is programmed to utilize one or more optical channel monitors (OCM) coupled to the input and/or output ports to detect which of the wavelengths are present at the input ports. Wavelengths that are not detected on any input port are blocked by the WSS. Any wavelength detected as present at one and only one input port is switched by the WSS to the output port. If a wavelength is detected at two or more input ports, it is either blocked by the WSS at each of the input ports until user intervention, or is blocked at all but one of the input ports as defined by assigned port priorities.

Abstract: A method is provided for selecting membrane-translocating peptides (MTPs) from a peptide display library that are capable of crossing or penetrating a lipid membrane. A plurality of nucleic acid constructs that encode displayed peptides are expressed, resulting in the formation of a plurality of nucleic acid-peptide complexes, each complex comprising at least one displayed peptide associated with the corresponding nucleic acid construct encoding the displayed peptide; the complexes are exposed to a population of membrane-encapsulated compartments, allowing a translocating reaction to occur; complexes that remain unassociated with the membrane are removed; optionally complexes that are associated with the membrane are removed; and internalised nucleic acid-peptide complexes are recovered. The membrane-encapsulated compartments may be artificial vesicles such as liposomes, or populations of one or more cell types.

Abstract: The present invention relates to nucleotide sequences which encode polypeptides of antibodies against the p53 protein in vertebrates, and to the polypeptides and antibodies (or fragments thereof) encoded by those nucleotide sequences. The invention also relates to nucleotide sequences and polypeptide sequences for use in the development of diagnostic and therapeutic compositions, and to methods of using those diagnostic and therpeutic compositions in the diagnosis and treatment of cancer, rheumatoid arthritis and other disease states which exhibit abnormalities of p53.

Abstract: The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are specifically associated with the DNA encoding them through non-covalent protein:DNA binding. The method describes ways of making the library itself, DNA molecules encoding the library and uses of the expression library.