Abstract: A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein A1 and A2 are independently O or S; X is selected from CH2, CD2, NR3, O, and S, where R3 is selected from hydrogen, C1-C4 linear or branched chain alkyl, halo(C1-C4)linear or branched chain alkyl, and hydroxyl(C1-C4)linear or branched chain alkyl; Y and Z are selected from C and N, where when Y is C, then Z is N, and when Y is N, then Z is C; R1 and R2 are independently selected from hydrogen, deuterium, C1-C4 linear or branched chain alkyl, etc.; or a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring; or taken together to form a C3-C6 cycloalkyl ring; or where X is CH2 or CD2, then R1 and R2 are independently selected from hydrogen, deuterium, halogen, hydroxyl, C1-C4 linear or branched chain alkyl, etc.; R4 is selected from hydrogen, deuterium, cyano, halogen, (C1-C3) alkoxy, etc.; R5 is selected from hydrogen, deuterium, halogen, C1-C3 alkoxy, amino, (C1-C4 linear or branched chain alkyl)amino, etc.

Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: A port assembly (100) is generally disclosed that has an annular port ring (110) configured for placement in a barrier wall (10). The annular port ring (110) defines a port opening (20) extending from a first end (22) to a second end (24) and an annular sealing surface (118) about the port opening (20) on the second end (24). A port cover (120) is mechanically coupleable to the annular port ring (110). The port cover (120) defines an annular mating surface (124) configured to couple to the annular sealing surface (118) of the annular port ring (110). A manually actuatable handle (130) is in mechanical communication with the port cover (120). The handle (130) extends from the first end (22) of the annular port ring (110) away from the second end (24).

Abstract: A distributed cooling system is disclosed. The system may include a first radiator to circulate a liquid coolant through the first radiator to cool the liquid coolant, a first fan, electrically connected to the first radiator, to facilitate cooling the liquid coolant, and a first temperature sensor to obtain first temperature data concerning the liquid coolant. The system may include a second radiator to circulate an oil through the second radiator to cool the oil, a second fan, electrically connected to the second radiator, to facilitate cooling the oil, and a second temperature sensor to obtain second temperature data concerning the oil. The system may include a heat exchanger to cool the liquid coolant and the oil and a controller, electrically connected to the first fan, the first temperature sensor, the second fan, and the second temperature sensor, to control the first fan and the second fan.

Abstract: A distributed cooling system is disclosed. The system may include a first radiator to circulate a liquid coolant through the first radiator to cool the liquid coolant, a first fan, electrically connected to the first radiator, to facilitate cooling the liquid coolant, and a first temperature sensor to obtain first temperature data concerning the liquid coolant. The system may include a second radiator to circulate an oil through the second radiator to cool the oil, a second fan, electrically connected to the second radiator, to facilitate cooling the oil, and a second temperature sensor to obtain second temperature data concerning the oil. The system may include a heat exchanger to cool the liquid coolant and the oil and a controller, electrically connected to the first fan, the first temperature sensor, the second fan, and the second temperature sensor, to control the first fan and the second fan.

Abstract: A port assembly (100) is generally disclosed that has an annular port ring (110) configured for placement in a barrier wall (10). The annular port ring (110) defines a port opening (20) extending from a first end (22) to a second end (24) and an annular sealing surface (118) about the port opening (20) on the second end (24). A port cover (120) is mechanically coupleable to the annular port ring (110). The port cover (120) defines an annular mating surface (124) configured to couple to the annular sealing surface (118) of the annular port ring (110). A manually actuatable handle (130) is in mechanical communication with the port cover (120). The handle (130) extends from the first end (22) of the annular port ring (110) away from the second end (24).

Abstract: A replacement glove assembly has a replacement access element defining an outermost shoulder end and an innermost hand end configured to receive a hand of a user. A replacement sealing assembly engages the outermost shoulder end of the replacement access element and defines a leading radial face defining a first coupling structure, a trailing radial face defining a second coupling structure, and an outer annular surface configured to be received by a glove port. A first glove cap has a first side and a second side opposite the first side. The first side defines a first mating structure sealably engaged with the first coupling structure of the leading radial face. The second side defines a second mating structure that is configured to sealably engage the second coupling structure of the trailing radial face of the replacement sealing assembly.

Abstract: A replacement glove assembly has a replacement access element defining an outermost shoulder end and an innermost hand end configured to receive a hand of a user. A replacement sealing assembly engages the outermost shoulder end of the replacement access element and defines a leading radial face defining a first coupling structure, a trailing radial face defining a second coupling structure, and an outer annular surface configured to be received by a glove port. A first glove cap has a first side and a second side opposite the first side. The first side defines a first mating structure sealably engaged with the first coupling structure of the leading radial face. The second side defines a second mating structure that is configured to sealably engage the second coupling structure of the trailing radial face of the replacement sealing assembly.

Abstract: A replacement glove assembly has a replacement access element defining an outermost shoulder end and an innermost hand end configured to receive a hand of a user. A replacement sealing assembly engages the outermost shoulder end of the replacement access element and defines a leading radial face defining a first coupling structure, a trailing radial face defining a second coupling structure, and an outer annular surface configured to be received by a glove port. A first glove cap has a first side and a second side opposite the first side. The first side defines a first mating structure sealably engaged with the first coupling structure of the leading radial face. The second side defines a second mating structure that is configured to sealably engage the second coupling structure of the trailing radial face of the replacement sealing assembly.

Abstract: A method and apparatus for providing an audible alarm signal. The method and apparatus includes creating a rectangular pulse signal having a desired period and a desired first amplitude, adding a shaped modulation component to the rectangular pulse signal from the desired first amplitude to a desired second amplitude to create a modulating waveform, creating a carrier signal, and combining the carrier signal and the modulating waveform to create the audible alarm signal.