Abstract: Provided are polypeptides, nucleic acids, vectors, cells and compositions useful for treating bacterial infections, particularly bacterial vaginosis (BV) and related conditions, particularly endolysin polypeptides derived from Gardnerella spp. Also provided is use of amino acid sequences to create a chimeric polypeptide having anti-Gardnerella spp. activity. Methods of treatment using the polypeptides, nucleic acids, vectors, cells and compositions are also provided.

Abstract: A method/system monitors and controls operational aspects of devices in a space, for example a living, office or other human-occupied space or storage space, in a building, such as turning lights on/off, raising/lowering blinds, maintaining or changing temperature, and other operational aspects. Sensors monitor energy usage of the devices in the space, and a controller/engine compares the monitored energy usage with reference energy usage to validate whether the devices are performing as expected. A temperate set-versus-anomaly detection technique may use temperature set point adjustments by a user (during a timeframe) to determine whether an anomaly exists that requires changes in the central plant of the building.

Abstract: A method/system monitors and controls operational aspects of devices in a space, for example a living, office or other human-occupied space or storage space, in a building, such as turning lights on/off, raising/lowering blinds, maintaining or changing temperature, and other operational aspects. Sensors monitor energy usage of the devices in the space, and a controller/engine compares the monitored energy usage with reference energy usage to validate whether the devices are performing as expected. A temperate set-versus-anomaly detection technique may use temperature set point adjustments by a user (during a timeframe) to determine whether an anomaly exists that requires changes in the central plant of the building.

Abstract: The present disclosure describes systems, methods, kits, and devices for detecting and treating a fungal infection in a subject. In particular, provided herein are host gene markers that can be used for identifying and treating an Aspergillus infection. The methods, devices, kits, and systems disclosed herein are used to classify subjects based on the expression levels of the identified gene markers. In some embodiments, the Aspergillus infection comprises an infection with Aspergillus fumigatus.

Abstract: Abstract Provided are polypeptides, nucleic acids, vectors, cells and compositions useful for treating bacterial infections, particularly bacterial vaginosis (BV) and related conditions, particularly endolysin polypeptides derived from Gardnerella spp. Also provided is use of amino acid sequences to create a chimeric polypeptide having anti-Gardnerella spp. activity. Methods of treatment using the polypeptides, nucleic acids, vectors, cells and compositions are also provided.

Abstract: The present invention relates to the discovery that certain microRNAs are differentially expressed in Idiopathic Pulmonary Fibrosis. The present invention provides for diagnostic methods, therapeutic methods, and kits related to these differentially expressed microRNAs.

Abstract: The present invention involves one or more computers that provide software controls to enable a web application to interface with a personal trusted device. The server side of the computer system comprises: a server-based framework process; a device for receiving requests from the client computer and determining which software controls to send in response; and a device for digitally signing and encrypting the software controls before sending them to the client computer so that their authenticity can be verified. The client side of the computer system comprises: a client web browser that runs on a computer; a device for transmitting requests to the server computer and for receiving responses from those requests; a device for decrypting software controls so that the authenticity of their digital signature can be verified; and a connection to one or more personal trusted devices. An authentication proxy may be used to mutually authenticate a client user and server process using personal trusted devices.

Abstract: A dynamic mate inferencing system permits display and manipulation of a computer model, including features of allowing a user to select a feature of the model, determining a characteristic geometry of the feature, dynamically previewing the mating of the feature to a component of the model, allowing the user to alternate between different mating scenarios, and permitting the user to mate the feature to the component in the previewed geometry.