Abstract: A network metrics repository stores performance metrics measured during operation of a communication network, and stores fault values indicating types of network operation faults. A neural network circuit has an input layer having input nodes, a sequence of hidden layers each having a plurality of combining nodes, and an output layer having an output node. A processor generates forecasted performance metrics based on extrapolating from measured performance metrics in the network metrics repository, and provides to the input nodes of the neural network circuit the forecasted performance metrics and the measured performance metrics. The processor adapts weights and/or firing thresholds that are used by the input nodes responsive to output of the output node, and controls operation of the communication network based on output of the output node. The output node provides the output responsive to processing through the input nodes a stream of measured performance metrics and forecasted performance metrics.

Abstract: A performance anomaly detector obtains a performance metric value from a performance measurement of operation of a resource, and determines a modified Z-score based on the. Occurrence of an anomaly event for the resource is detected responsive to determining that: 1) the modified Z-score exceeds a Z-score anomaly threshold; and 2) a threshold number of other modified Z-scores, which are determined for the other performance metric values in the sequence and are within a sequence window range of the performance metric value, also exceed the Z-score anomaly threshold. A remedial action for the resource is initiated responsive to detecting the occurrence of the anomaly event for the resource.

Abstract: A method may provide performance management for a data communication network including a plurality of network elements. The method may include defining a cluster of the network elements for a performance metric, and defining one of the network elements of the cluster as a proxy network element for the cluster. A proxy baseline of the performance metric for the cluster may be calculated based on performance metric data for the proxy network element, and the performance metric for each of the network elements of the cluster may be monitored using the proxy baseline of the performance metric. Related systems and computer program products are also discussed.

Abstract: The present description includes containers having an improved puncture design that can be punctured without substantial deformation of the container. Such containers are particularly suitable for use in preparing beverages using automatic machines, particularly those used for preparation of single serve beverages. Also provided are thermoplastic materials having improved punctureability for use in containers, containers for preparation of a beverage, and methods for preparing a beverage using such containers.

Abstract: A performance anomaly detector obtains a performance metric value from a performance measurement of operation of a resource, and determines a modified Z-score based on the. Occurrence of an anomaly event for the resource is detected responsive to determining that: 1) the modified Z-score exceeds a Z-score anomaly threshold; and 2) a threshold number of other modified Z-scores, which are determined for the other performance metric values in the sequence and are within a sequence window range of the performance metric value, also exceed the Z-score anomaly threshold. A remedial action for the resource is initiated responsive to detecting the occurrence of the anomaly event for the resource.

Abstract: A method may provide performance management for a data communication network including a plurality of network elements. The method may include defining a cluster of the network elements for a performance metric, and defining one of the network elements of the cluster as a proxy network element for the cluster. A proxy baseline of the performance metric for the cluster may be calculated based on performance metric data for the proxy network element, and the performance metric for each of the network elements of the cluster may be monitored using the proxy baseline of the performance metric. Related systems and computer program products are also discussed.

Abstract: The present description includes containers having an improved puncture design that can be punctured without substantial deformation of the container. Such containers are particularly suitable for use in preparing beverages using automatic machines, particularly those used for preparation of single serve beverages. Also provided are thermoplastic materials having improved punctureability for use in containers, containers for preparation of a beverage, and methods for preparing a beverage using such containers.

Abstract: The present invention relates to a novel co-crystal of the compound of formula (I): wherein the co-former molecule is acetyl salicylic acid, to processes for the preparation of the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the prevention of arterial thrombotic complications in patients with coronary artery, cerebrovascular or peripheral vascular disease and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of a such a co-crystal.

Abstract: The present invention relates to a novel co-crystal of the compound of formula (I): wherein the co-former molecule is acetyl salicylic acid, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the prevention of arterial thrombotic complications in patients with coronary artery, cerebrovascular or peripheral vascular disease and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of a such a co-crystal.

Abstract: Methods include receiving at a receiving device a plurality of reports, each corresponding to at least one item and comprising data associated with one or more performance metrics. The methods further include identifying events for each report corresponding to at least one item using the data in the report. In addition, the methods include determining a report score for each report based on a number and type of the identified events. The methods also include outputting the report scores.

Abstract: The present invention relates to novel co-crystal forms of the compound of formula (I); wherein the co-former molecule is selected from glycolic acid, salicylic acid, decanoic (capric) acid, gentisic acid (2,5-dihydroxybenzoic acid), glutaric acid, vanillic acid (4-hydroxy-3-methoxybenzoic acid), succinic acid, malonic acid or maltol (3-hydroxy-2-methyl-4-pyrone); and to processes for their preparation, to pharmaceutical compositions containing such co-crystals, to the use of such co-crystals in the manufacture of a medicament for use in the prevention of arterial thrombotic complications in patients with coronary artery, cerebrovascular or peripheral vascular disease and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of a co-crystal of the compound of formula (I).

Abstract: Methods include receiving at a receiving device a plurality of reports, each corresponding to at least one item and comprising data associated with one or more performance metrics. The methods further include identifying events for each report corresponding to at least one item using the data in the report. In addition, the methods include determining a report score for each report based on a number and type of the identified events. The methods also include outputting the report scores.

Abstract: The present invention relates to a novel co-crystal of the compound of formula (I): wherein the co-former molecule is acetyl salicylic acid, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the prevention of arterial thrombotic complications in patients with coronary artery, cerebrovascular or peripheral vascular disease and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of a such a co-crystal.

Abstract: Polymorphs of 7-methyl-5-(3-piperazin-1-ylmethyl-[1,2,4]oxadiazol-5-yl)-2-(4-trifluoromethoxybenzyl)-2,3-dihydroisoindol-1-one mesylate salt, methods of making these polymorphs and uses thereof.

Abstract: The present invention relates to novel co-crystal forms of the compound of formula (I); wherein the co-former molecule is selected from glycolic acid, salicylic acid, decanoic (capric) acid, gentisic acid (2,5-dihydroxybenzoic acid), glutaric acid, vanillic acid (4-hydroxy-3-methoxybenzoic acid), succinic acid, malonic acid or maltol (3-hydroxy-2-methyl-4-pyrone); and to processes for their preparation, to pharmaceutical compositions containing such co-crystals, to the use of such co-crystals in the manufacture of a medicament for use in the prevention of arterial thrombotic complications in patients with coronary artery, cerebrovascular or peripheral vascular disease and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of a co-crystal of the compound of formula (I).