Abstract: A system is provided that considers allele fraction shifts as a function of copy number and clonal heterogeneity. The system leverages differences between allele frequencies to differentiate between somatic and normal variants in impure tumor samples. In solid tumors, stromal cells and infiltrating lymphocytes are typically interspersed among the tumor cells. The normal cell contamination in tumors can be leveraged to differentiate somatic from germline variants. We explicitly model allelic copy number and clonal sample fractions so that we can examine how these factors impact the power to detect somatic variants. The system models the copy number alterations, which can also affect the allele frequencies of both somatic and germline variants. The expected allele frequencies can be calculated. The expected allele frequencies for somatic and germline differ with tumor content for different copy number alterations.

Abstract: Disclosed herein are methods of modulating the activity of a thyroid hormone receptor beta and methods of treating disease using a pyridazinone compound.

Abstract: Methods and systems are provided for road condition classification that include one or more sensors configured to obtain sensor data pertaining to operation of a vehicle along a roadway by a human; and one or more processors that are coupled to the one or more sensors and that are configured to at least facilitate analyzing the sensor data as to one or more threshold values pertaining to the operation of the vehicle; and identifying one or more conditions of the roadway, based on the analyzing of the sensor data. Further, learned input is provided to the vehicle control system to operate with lane position behavior similar to a human driven vehicle.

Abstract: A magnetic transmission system includes an outer gear ring including an outer plurality of permanent magnets and configured to rotate about a rotational drive axis, an inner gear ring positioned within the outer gear ring and including an inner plurality of permanent magnets magnetically coupled to the outer plurality of permanent magnets, and an eccentric bearing assembly configured to convert orbital motion of the inner gear ring about the rotational drive axis into rotational motion of the eccentric bearing assembly about a bearing rotational axis that is radially offset from the rotational drive axis, and a first drive shaft coupled to the outer gear ring and a second drive shaft coupled to the inner gear ring, wherein the outer gear ring and the inner gear ring are configured to provide a gear ratio between the first drive shaft and the second drive shaft.

Abstract: A material collection vehicle may include a vehicle body and a mounting system including a turret sealingly coupled to a boom mounting joint. The mounting system may be used for mounting a telescopic boom assembly. The boom assembly may include a bearing seal to provide for sealed fluid communication through the boom assembly. The mounting system and boom assembly may form a sealed fluid flow path from the boom assembly to the vehicle body through the mounting system.

Abstract: In one embodiment, an apparatus for dispensing a liquid is disclosed. The apparatus can comprise a cap configured to connect to a container body having a chamber for containing the liquid. The cap can comprise a pour aperture through which the liquid exits the apparatus. The cap can comprise a pour lid configured to open and close the pour aperture. The cap can comprise a cap vent configured to allow air to flow from the outside environs into the chamber of the container body when the cap is connected to the container body.

Abstract: B-cell maturation antigen (BCMA) is expressed on malignant plasma cells. The present invention provides BCMA-specific chimeric antigen receptors and cells expressing such chimeric antigen receptors. In certain embodiments, engineered cells expressing the chimeric antigen receptors of the present invention are capable of inhibiting the growth of tumors expressing BCMA. The engineered cells of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced BCMA-targeted immune response is desired and/or therapeutically beneficial. For example, engineered cells expressing the BCMA-specific chimeric antigen receptors of the invention are useful for the treatment of various cancers, including multiple myeloma.

Abstract: Techniques described herein are directed to analyzing intellectual-property data according to provide various intellectual property related services to organizations. In particular implementations, information related to products and/or services may be obtained from a number of data sources. Additionally, information related to intellectual-property assets, such as patents, trademarks, copyrights, trade secrets, and know-how, may be obtained. In various situations, the intellectual-property assets may be mapped to respective products and/or services. The mappings between the products and/or services and intellectual-property assets may be used to provide intellectual property related services that correspond to the intellectual-property assets, such as valuation services, strategy-related services, or risk-related services.

Abstract: A platform and components for an automated consumer retail utility marketplace are provided, including components for machine learning, components for gamification, and components for supporting a related consumer mobile application that enables improved visibility and control by a consumer over its interaction with energy markets.

Abstract: An article tracking system including: a plurality of tags, each tag being attached to a respective article in use and including: a power supply; a tag transceiver that transmits or receives messages; and a tag processing device; a number of tag readers, each tag reader including: at least one reader transceiver that transmits or receives messages; and, a reader processing device in communication with the at least one tag reader; and, at least one processing system in communication with the number of tag readers, and wherein in use each tag reader: generates a message; and, transmits the message to one or more tags within an operating range of the reader, wherein ones of the one or more tags in a passive operating mode are responsive to the message to: receive the message; selectively change a tag operating mode; and, if the message is a broadcast message, transmit a tag message at least partially indicative of an identity of the tag; receives any tag messages; generates location data at least partially indica

Abstract: Disclosed herein are adjuvanted protein vaccines comprising: a non-phospholipid liposome and one or more proteins, wherein the protein is encapsulated within the non-phospholipid liposome, and wherein the protein is selected from: (i) a modified full-length spike protein that generates IgG antibody responses for 120 days after two injections of the adjuvanted protein vaccine, by subcutaneous or intramuscular routes; (ii) a modified spike protein sequence of a coronavirus; (iii) a protein sequence from a coronavirus; and (iv) a protein from an infectious agent that generates IgG antibody responses to proteins after one or two subcutaneous or intramuscular injections. Also disclose herein are modified spike protein sequence containing a modified full-length SARS-COV-2 spike protein sequence. Methods of use of the vaccines and sequences are also disclosed herein.

Abstract: Various devices, assemblies, components, systems, and methos are provided relating to a loading and/or unloading system. An example system may include at least one lifting portion and a movement portion. The lifting portion may be configured to move a basket in a plurality of directions to assist with loading/unloading at a plurality of stations. The movement portion may be configured to transport the lifting portion in the length direction.

Abstract: A method for processing a function command for a peripheral device, the method that includes obtaining, by a device controller intermediary, a function command from a virtual machine, where the function command is associated with a peripheral device, performing a lookup, in a function policy database to identify an emulated function policy associated with the function command, making a determination that the function command does not violate the emulated function policy, and in response to the determination, forwarding the function command to the peripheral device.

Abstract: A method for processing a function command, the method that includes obtaining, by a device controller intermediary, a function command from a virtual machine, where the function command is associated with a peripheral device, making a first determination that the function command is associated with a remote peripheral device, forwarding the function command to the remote peripheral device, and in response to forwarding the function command, receiving processed data from the remote peripheral device, and providing the processed data to the virtual machine.

Abstract: An LCS ePF-enabled resource system includes a resource system coupled to a resource management system and resource device(s) configured to provide resource functionality. The resource system includes a microvisor subsystem that the resource management system configures to provide an LCS and an ePF that is presented to the LCS as providing the resource functionality. When the microvisor subsystem receives an LCS request for the resource functionality from an LCS API subsystem in the LCS via the ePF, it transmits a microvisor request to the resource management system for the resource functionality that causes the resource management system to identify the resource device(s) for providing the resource functionality. Based on the identification of the resource device(s), the microvisor subsystem establishes a communication channel with each resource device, and provides the resource functionality to the LCS using the resource device(s) and via each communication channel, the ePF, and the LCS API subsystem.

Abstract: A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, ?-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched Ci to

Abstract: A method of assembling a tandem permanent magnet motor includes the steps of using an external visual reference system to align the stator assembly of the upper permanent magnet motor with the stator assembly of the lower permanent magnet motor. The external visual reference system includes a series of external reference marks that provide a mechanism for quickly aligning the upper and lower permanent magnet motors in the field prior to installation in a well as part of an electric submersible pumping system.

Abstract: A method is provided of forming a stain assessment target for a biological material staining system. At least one region of a substrate is provided upon a support such as a microscope slide. The substrate is formed from an optically transmissive material which is an analogue of biological tissue. A biological tissue sample for inspection is also provided upon the support. The support, including the at least one region, together with the biological tissue sample and then stained by applying at least one biological tissue stain under similar staining conditions.

Abstract: A trailer towable compact telehandler having an operator cab with an internal width greater than 700 mm and a curbside weight less than 2950 kg. Also included is a telehandler having a side-mounted engine which extends through a side wall of the chassis and under a lifting arm of the telehandler. Also included is a compact tool carrier having a reduced fore-aft dimension between an attachment plane and a principal pivot member.

Abstract: Techniques described herein are directed to analyzing intellectual-property data according to provide various intellectual property related services to organizations. In particular implementations, information related to products and/or services may be obtained from a number of data sources. Additionally, information related to intellectual-property assets, such as patents, trademarks, copyrights, trade secrets, and know-how, may be obtained. In various situations, the intellectual-property assets may be mapped to respective products and/or services. The mappings between the products and/or services and intellectual-property assets may be used to provide intellectual property related services that correspond to the intellectual-property assets, such as valuation services, strategy-related services, or risk-related services.