Abstract: In one aspect, an agricultural implement includes a row unit including a frame. A center coulter can be operably coupled with the frame. A knife can be operably coupled with the frame and positioned aft of the center coulter. A diverging gap can be defined between the center coulter and the knife such that the diverging gap increases in width in the forward/aft direction as a location along the knife moves upward.

Abstract: In one embodiment, an apparatus for dispensing a liquid is disclosed. The apparatus can comprise a cap configured to connect to a container body having a chamber for containing the liquid. The cap can comprise a pour aperture through which the liquid exits the apparatus. The cap can comprise a pour lid configured to open and close the pour aperture. The cap can comprise a cap vent configured to allow air to flow from the outside environs into the chamber of the container body when the cap is connected to the container body.

Abstract: Systems and methods for dataset distinctiveness modeling are disclosed. For example, databases may be queried for datasets associated with intellectual property assets, particularly trademarks. A vector representation may be generated for the mark in question, and a vector representation may be generated for the description of goods and/or services associated with the mark. A machine learning model may be trained to predict a distinctiveness score based on the vector representations, similarity metrics between the trademark and other marks, goods and services of the other marks, and context data associated with the trademarks.

Abstract: Systems and methods for digital property authentication and management are disclosed. A document representing a trade secret may be requested to be registered with a trade secret registry. A document obfuscation value corresponding to the document may be generated and may be registered with a blockchain. A record of the registration may be generated for the trade secret registry. The registry may be searchable and/or offer functionality such as valuation, insurance provision, and/or verification, among other benefits and functionalities.

Abstract: A system is provided that considers allele fraction shifts as a function of copy number and clonal heterogeneity. The system leverages differences between allele frequencies to differentiate between somatic and normal variants in impure tumor samples. In solid tumors, stromal cells and infiltrating lymphocytes are typically interspersed among the tumor cells. The normal cell contamination in tumors can be leveraged to differentiate somatic from germline variants. We explicitly model allelic copy number and clonal sample fractions so that we can examine how these factors impact the power to detect somatic variants. The system models the copy number alterations, which can also affect the allele frequencies of both somatic and germline variants. The expected allele frequencies can be calculated. The expected allele frequencies for somatic and germline differ with tumor content for different copy number alterations.

Abstract: Disclosed herein are methods of modulating the activity of a thyroid hormone receptor beta and methods of treating disease using a pyridazinone compound.

Abstract: Methods and systems are provided for road condition classification that include one or more sensors configured to obtain sensor data pertaining to operation of a vehicle along a roadway by a human; and one or more processors that are coupled to the one or more sensors and that are configured to at least facilitate analyzing the sensor data as to one or more threshold values pertaining to the operation of the vehicle; and identifying one or more conditions of the roadway, based on the analyzing of the sensor data. Further, learned input is provided to the vehicle control system to operate with lane position behavior similar to a human driven vehicle.

Abstract: Techniques described herein are directed to analyzing intellectual-property data according to provide various intellectual property related services to organizations. In particular implementations, information related to products and/or services may be obtained from a number of data sources. Additionally, information related to intellectual-property assets, such as patents, trademarks, copyrights, trade secrets, and know-how, may be obtained. In various situations, the intellectual-property assets may be mapped to respective products and/or services. The mappings between the products and/or services and intellectual-property assets may be used to provide intellectual property related services that correspond to the intellectual-property assets, such as valuation services, strategy-related services, or risk-related services.

Abstract: Disclosed herein are adjuvanted protein vaccines comprising: a non-phospholipid liposome and one or more proteins, wherein the protein is encapsulated within the non-phospholipid liposome, and wherein the protein is selected from: (i) a modified full-length spike protein that generates IgG antibody responses for 120 days after two injections of the adjuvanted protein vaccine, by subcutaneous or intramuscular routes; (ii) a modified spike protein sequence of a coronavirus; (iii) a protein sequence from a coronavirus; and (iv) a protein from an infectious agent that generates IgG antibody responses to proteins after one or two subcutaneous or intramuscular injections. Also disclose herein are modified spike protein sequence containing a modified full-length SARS-COV-2 spike protein sequence. Methods of use of the vaccines and sequences are also disclosed herein.

Abstract: A method for processing a function command, the method that includes obtaining, by a device controller intermediary, a function command from a virtual machine, where the function command is associated with a peripheral device, making a first determination that the function command is associated with a remote peripheral device, forwarding the function command to the remote peripheral device, and in response to forwarding the function command, receiving processed data from the remote peripheral device, and providing the processed data to the virtual machine.

Abstract: An LCS ePF-enabled resource system includes a resource system coupled to a resource management system and resource device(s) configured to provide resource functionality. The resource system includes a microvisor subsystem that the resource management system configures to provide an LCS and an ePF that is presented to the LCS as providing the resource functionality. When the microvisor subsystem receives an LCS request for the resource functionality from an LCS API subsystem in the LCS via the ePF, it transmits a microvisor request to the resource management system for the resource functionality that causes the resource management system to identify the resource device(s) for providing the resource functionality. Based on the identification of the resource device(s), the microvisor subsystem establishes a communication channel with each resource device, and provides the resource functionality to the LCS using the resource device(s) and via each communication channel, the ePF, and the LCS API subsystem.

Abstract: A method for processing a function command for a peripheral device, the method that includes obtaining, by a device controller intermediary, a function command from a virtual machine, where the function command is associated with a peripheral device, performing a lookup, in a function policy database to identify an emulated function policy associated with the function command, making a determination that the function command does not violate the emulated function policy, and in response to the determination, forwarding the function command to the peripheral device.

Abstract: A trailer towable compact telehandler having an operator cab with an internal width greater than 700 mm and a curbside weight less than 2950 kg. Also included is a telehandler having a side-mounted engine which extends through a side wall of the chassis and under a lifting arm of the telehandler. Also included is a compact tool carrier having a reduced fore-aft dimension between an attachment plane and a principal pivot member.

Abstract: Techniques described herein are directed to analyzing intellectual-property data according to provide various intellectual property related services to organizations. In particular implementations, information related to products and/or services may be obtained from a number of data sources. Additionally, information related to intellectual-property assets, such as patents, trademarks, copyrights, trade secrets, and know-how, may be obtained. In various situations, the intellectual-property assets may be mapped to respective products and/or services. The mappings between the products and/or services and intellectual-property assets may be used to provide intellectual property related services that correspond to the intellectual-property assets, such as valuation services, strategy-related services, or risk-related services.

Abstract: The present disclosure provides a novel endoscopic imaging capsule and related methods. The capsule comprises a controller which causes a camera module to capture and transmit images while still inside a patient's gastrointestinal tract, transferring them to a predesignated IP address that is accessible by external devices, allowing the images to be accessed much faster. The capsule also has a rectangular profile, with lighting elements arranged to emit light orthogonally to the rectangular profile, providing a brighter, more focused image. It can also be encased in a gelatinous film to facilitate easier swallowing.

Abstract: A system is provided that considers allele fraction shifts as a function of copy number and clonal heterogeneity. The system leverages differences between allele frequencies to differentiate between somatic and normal variants in impure tumor samples. In solid tumors, stromal cells and infiltrating lymphocytes are typically interspersed among the tumor cells. The normal cell contamination in tumors can be leveraged to differentiate somatic from germline variants. We explicitly model allelic copy number and clonal sample fractions so that we can examine how these factors impact the power to detect somatic variants. The system models the copy number alterations, which can also affect the allele frequencies of both somatic and germline variants. The expected allele frequencies can be calculated. The expected allele frequencies for somatic and germline differ with tumor content for different copy number alterations.

Abstract: Disclosed herein are subcutaneously administered, immunogenic compositions (e.g., vaccines) and methods of using and preparing the same. In some embodiments, the immunogenic compositions generate IgG antibodies to the spike proteins of the Wuhan-Hu-1, Delta B.1.617.2, and Omicron BA.1 variants of SARS-CoV-2 and may be suitable for use in preventing an infectious disease, such as SARS-CoV-2.

Abstract: A trailer towable compact telehandler having an operator cab with an internal width greater than 700 mm and a curbside weight less than 2950 kg. Also included is a telehandler having a side-mounted engine which extends through a side wall of the chassis and under a lifting arm of the telehandler. Also included is a compact tool carrier having a reduced fore-aft dimension between an attachment plane and a principal pivot member.

Abstract: Techniques described herein are directed to analyzing intellectual-property data according to provide various intellectual property related services to organizations. In particular implementations, information related to products and/or services may be obtained from a number of data sources. Additionally, information related to intellectual-property assets, such as patents, trademarks, copyrights, trade secrets, and know-how, may be obtained. In various situations, the intellectual-property assets may be mapped to respective products and/or services. The mappings between the products and/or services and intellectual-property assets may be used to provide intellectual property related services that correspond to the intellectual-property assets, such as valuation services, strategy-related services, or risk-related services.

Abstract: Systems and methods for digital property authentication and management are disclosed. A document representing a trade secret may be requested to be registered with a trade secret registry. A document obfuscation value corresponding to the document may be generated and may be registered with a blockchain. A record of the registration may be generated for the trade secret registry. The registry may be searchable and/or offer functionality such as valuation, insurance provision, and/or verification, among other benefits and functionalities.