Abstract: The present invention relates to the use of cannabidiol (CBD) in the treatment of patients with childhood-onset epilepsy who are concurrently taking caffeine. Where the CBD is used in combination with caffeine, caution should be taken. For example, the dose of either the CBD and/or caffeine may be required to be reduced. Moreover, the patient may need to be monitored for side effects of said drug-drug interaction. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 95% of the total extract (w/w) and the other components of the extract are characterised. In particular the cannabinoid tetrahydrocannabinol (THC) has been substantially removed, to a level of not more than 0.15% (w/w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD.

Abstract: The present disclosure provides methods of treating tuberous sclerosis complex comprising administering cannabidiol and everolimus.

Abstract: The present disclosure provides methods of treating tuberous sclerosis complex comprising administering cannabidiol and everolimus.

Abstract: The present disclosure provides methods of treating tuberous sclerosis complex comprising administering cannabidiol and everolimus.

Abstract: The present disclosure provides methods of treating tuberous sclerosis complex comprising administering cannabidiol and everolimus.

Abstract: The present disclosure provides methods of treating tuberous sclerosis complex comprising administering cannabidiol and everolimus.

Abstract: Aspects of the disclosure relate to a front grille and a motor vehicle hood assembly, as well as methods of installing the front grille to the hood assembly. The front grille includes a peripheral frame with left and right members and a plurality of fasteners extending rearward from the left member and the right member. The hood assembly includes medially extending tab members and insertion gaps arranged proximate to left and right sides of a front aperture defined in the hood assembly. Each tab member is separated from each other tab member by at least one of the insertion gaps. During mounting, the plurality of fasteners of the front grille are inserted into the insertion gaps, and the front grille is slid upward relative to the hood assembly, causing the fasteners to slidably engage the tab members. Sliding engagement of the fasteners reduces stress on the front grille from hood deflection.

Abstract: Aspects of the disclosure relate to a front grille and a motor vehicle hood assembly, as well as methods of installing the front grille to the hood assembly. The front grille includes a peripheral frame with left and right members and a plurality of fasteners extending rearward from the left member and the right member. The hood assembly includes medially extending tab members and insertion gaps arranged proximate to left and right sides of a front aperture defined in the hood assembly. Each tab member is separated from each other tab member by at least one of the insertion gaps. During mounting, the plurality of fasteners of the front grille are inserted into the insertion gaps, and the front grille is slid upward relative to the hood assembly, causing the fasteners to slidably engage the tab members. Sliding engagement of the fasteners reduces stress on the front grille from hood deflection.