Abstract: Disclosed are agents, compositions and methods of treating or controlling Botrytis infection particularly in plants. Certain agents include polynucleotide molecules that induce RNAi when administered to B. cinerea fungal cells. In particular embodiments, compositions include a fungicidally effective amount of a polynucleotide comprising at least 18, 19, 20, 21, 25, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 575, or 600 contiguous nucleotides that are essentially complementary to or comprises at least about 85%, at least about 90%, at least about 95%, at least about 98%, about 100%, or 100% sequence identity with a segment of a DNA or target gene of B. cinerea, or an RNA transcribed from the DNA or target gene.