Abstract: A portable electronic device may include a housing member, a rear cover coupled to the housing member, and a top module coupled to the housing member and including a front cover defining an exterior surface and an interior surface opposite to the exterior surface, a display stack attached to the interior surface of the front cover and comprising a flexible circuit element extending from a side of the display stack, a frame member attached to the interior surface of the front cover and extending at least partially around a periphery of the display stack, and an encapsulating structure positioned between the frame member and the display stack and at least partially encapsulating a portion of a peripheral side of the display stack and the flexible circuit element. The encapsulating structure may cover at least a portion of a bottom side of the display stack.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: Multiple inlet vacuum system having parallel exhausters, air admission valves upstream of inlets, and differential vacuum sensors and exhauster amperage sensors controlling the valves.