Patents by Inventor David D. Halbert

David D. Halbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamers and uses thereof
    Patent number: 10942184
    Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: March 9, 2021
    Assignee: Caris Science, Inc.
    Inventors: David D. Halbert, Valeriy Domenyuk, David Spetzler, Tassilo Hornung, Frank Schafer, Nianqing Xiao
  • Biomarkers for theranostics
    Patent number: 9128101
    Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: September 8, 2015
    Assignee: Caris Life Sciences Switzerland Holdings GmbH
    Inventors: David D. Halbert, George Poste, Michael Klass, David Spetzler, Traci Pawlowski, Daniel Holterman
  • BIOMARKERS FOR THERANOSTICS
    Publication number: 20130287772
    Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
    Type: Application
    Filed: March 1, 2011
    Publication date: October 31, 2013
    Applicant: Caris Life Sciences Luxembourg Holdings
    Inventors: David D. Halbert, Christine Kuslich, George Poste, Micheal Klass, Daniel Spetzler, Andrea Tasinato, Daniel Holterman