Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

Abstract: A primer removal tool (10) includes a receiving member (12) pivotally coupled to a guide rod assembly (14). An actuating member (16) is pivotally coupled to the receiving member (12) and the guide rod assembly (14). A first spring (18) is coupled between the receiving member (12) and the guide rod assembly (14). A second spring (20) is coupled between the guide rod assembly (14) and the actuating member (16). Pressure applied between the receiving member (12) and the actuating member (16) compresses the first spring (18) to allow the guide rod assembly (14) to enter the receiving member (12). Additional pressure compresses the second spring (20) to force the guide rod assembly (14) to move toward a press plate (24) of the receiving member (12). The guide rod assembly (14) forces a shell casing (30) against the press plate (24) to allow a de-priming pin (22) of the guide rod assembly (14) to separate a spent primer (32) from the shell casing (30) through an aperture (26) of the press plate (24).