Patents by Inventor David D. Manning

David D. Manning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid phase micro-extraction (SPME) devices
    Patent number: 9861909
    Abstract: Provided herein are improved solid phase micro-extraction (SPME) devices, systems comprising such devices, and methods of use and manufacture thereof. In particular, SPME devices provided herein are configured to prevent damage (e.g., to the device and/or to a system in which they are employed) incurred, for example, through user error.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: January 9, 2018
    Assignee: Smiths Detections Inc.
    Inventors: David D. Manning, Kenneth C. Schreiber, Kenneth J. Fredeen, George E. Riehm, Greg Weaver, John R. Laverack
  • LIGAND-THERAPEUTIC AGENT CONJUGATES, SILICON-BASED LINKERS, AND METHODS FOR MAKING AND USING THEM
    Publication number: 20160235858
    Abstract: The present invention relates to ligand-therapeutic agent conjugate compounds, silicon linkers for the conjugate compounds, compositions, methods for making them, and methods for the treatment of cancer using the conjugate compounds. The silicon-based linkers described herein can be used to deliver desired therapeutic agents to particular cells or tissue types targeted by the ligand.
    Type: Application
    Filed: April 29, 2016
    Publication date: August 18, 2016
    Inventors: Peter R. Guzzo, David D. Manning
  • Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
    Patent number: 9403776
    Abstract: The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: August 2, 2016
    Assignee: Albany Molecular Research, Inc.
    Inventors: Bruce F. Molino, Shuang Liu, Aruna Sambandam, Peter R. Guzzo, Min Hu, Congxiang Zha, Kassoum Nacro, David D. Manning, Matthew L. Isherwood, Kristen N. Ryan, Wenge Cui, Richard E. Olson
  • Ligand-therapeutic agent conjugates, silicon-based linkers, and methods for making and using them
    Patent number: 9352049
    Abstract: The present invention relates to ligand-therapeutic agent conjugate compounds, silicon linkers for the conjugate compounds, compositions, methods for making them, and methods for the treatment of cancer using the conjugate compounds. The silicon-based linkers described herein can be used to deliver desired therapeutic agents to particular cells or tissue types targeted by the ligand.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 31, 2016
    Assignee: Albany Molecular Research, Inc.
    Inventors: Peter R. Guzzo, David D. Manning
  • 5-HT3 receptor modulators, methods of making, and use thereof
    Patent number: 9045501
    Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: June 2, 2015
    Assignee: Albany Molecular Research, Inc.
    Inventors: Peter R. Guzzo, David D. Manning, William Earley
  • NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF
    Publication number: 20140315255
    Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
    Type: Application
    Filed: February 13, 2014
    Publication date: October 23, 2014
    Applicant: Albany Molecular Research, Inc.
    Inventors: Grant J. Carr, David D. Manning, Zhicai Yang, Cheng Guo, Jun-Ho Maeng, John RABENSTEIN
  • SOLID PHASE MICRO-EXTRACTION (SPME) DEVICES
    Publication number: 20140311985
    Abstract: Provided herein are improved solid phase micro-extraction (SPME) devices, systems comprising such devices, and methods of use and manufacture thereof. In particular, SPME devices provided herein are configured to prevent damage (e.g., to the device and/or to a system in which they are employed) incurred, for example, through user error.
    Type: Application
    Filed: November 14, 2012
    Publication date: October 23, 2014
    Applicant: Smiths Detections Inc.
    Inventors: David D. Manning, Kenneth C. Schreiber, Kenneth J. Fredeen, George E. Riehm, Greg Weaver, John R. Laverack
  • ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN
    Publication number: 20140296514
    Abstract: The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
    Type: Application
    Filed: June 13, 2014
    Publication date: October 2, 2014
    Inventors: Bruce F. Molino, Shuang Liu, Aruna Sambandam, Peter R. Guzzo, Min Hu, Congxiang Zha, Kassoum Nacro, David D. Manning, Matthew L. Isherwood, Kristen N. Fleming, Wenge Cui, Richard E. Olson
  • LIGAND-THERAPEUTIC AGENT CONJUGATES, SILICON-BASED LINKERS, AND METHODS FOR MAKING AND USING THEM
    Publication number: 20140274951
    Abstract: The present invention relates to ligand-therapeutic agent conjugate compounds, silicon linkers for the conjugate compounds, compositions, methods for making them, and methods for the treatment of cancer using the conjugate compounds. The silicon-based linkers described herein can be used to deliver desired therapeutic agents to particular cells or tissue types targeted by the ligand.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: Albany Molecular Research, Inc.
    Inventors: Peter R. Guzzo, David D. Manning
  • 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF
    Publication number: 20140234443
    Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
    Type: Application
    Filed: March 10, 2014
    Publication date: August 21, 2014
    Applicant: Albany Molecular Research, Inc.
    Inventors: Peter R. GUZZO, David D. MANNING, William EARLEY
  • Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
    Patent number: 8791101
    Abstract: The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: July 29, 2014
    Assignees: Albany Molecular Research, Inc., Bristol-Myers Squibb Company
    Inventors: Bruce F. Molino, Shuang Liu, Aruna Sambandam, Peter R. Guzzo, Min Hu, Congxiang Zha, Kassoum Nacro, David D. Manning, Matthew L. Isherwood, Kristen N. Fleming, Wenge Cui, Richard E. Olson
  • Antibacterial compounds, methods of making them, and uses thereof
    Patent number: 8754054
    Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: June 17, 2014
    Assignee: Albany Molecular Research, Inc.
    Inventors: Grant J. Carr, David D. Manning, Zhicai Yang, Cheng Guo, Jun-Ho Maeng, Peter C. Michels, Matthew W. Chase
  • 5-HTreceptor modulators, methods of making, and use thereof
    Patent number: 8710046
    Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: April 29, 2014
    Assignee: Albany Molecular Research, Inc.
    Inventors: Peter R. Guzzo, David D. Manning, William Earley
  • 5-HTreceptor modulators, methods of making, and use thereof
    Patent number: 8710047
    Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: April 29, 2014
    Assignee: Albany Molecular Research, Inc.
    Inventors: David D. Manning, Christopher L. Cioffi
  • 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF
    Publication number: 20130310366
    Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
    Type: Application
    Filed: July 12, 2013
    Publication date: November 21, 2013
    Applicant: Albany Molecular Research, Inc.
    Inventors: David D. MANNING, Christopher L. CIOFFI
  • NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF
    Publication number: 20130237490
    Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
    Type: Application
    Filed: September 17, 2010
    Publication date: September 12, 2013
    Applicant: Albany Molecular Research, Inc.
    Inventors: Grant J. CARR, David D. MANNING, Zhicai YANG, Cheng GUO, Jun-Ho MAENG, John RABENSTEIN, Peter C. MICHELS, Matthew W. CHASE
  • 5-HTreceptor modulators, methods of making, and use thereof
    Patent number: 8501729
    Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: August 6, 2013
    Assignee: Albany Molecular Research, Inc.
    Inventors: David D. Manning, Christopher Lawrence Cioffi
  • Therapeutic agents, and methods of making and using the same
    Patent number: 8450307
    Abstract: In part, the present invention is directed to antibacterial compounds.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: May 28, 2013
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Bruce J. Sargent, Henry Pauls, Judd M. Berman, Jailall Ramnauth, Peter Sampson, Andras Toro, Fernando J. Martin, Matthew D. Surman, Helene Y. Decornez, David D. Manning
  • 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF
    Publication number: 20120270857
    Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 25, 2012
    Applicant: ALBANY MOLECULAR RESEARCH, INC.
    Inventors: Peter R. Guzzo, David D. Manning, William Earley
  • 2-alkylbenzoxazole carboxamides as 5HT3 modulators
    Patent number: 8278301
    Abstract: Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: October 2, 2012
    Assignee: Albany Molecular Research, Inc.
    Inventors: David D. Manning, Zhicai Yang