Patents by Inventor David D. McKemy
David D. McKemy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9932383Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. In some embodiments, an isolated or recombinant CMR1 polypeptide is directly or indirectly attached to a detectable label or fused to a second polypeptide. In some embodiments, an isolated or recombinant CMR1 polypeptide is directly or indirectly bound to a solid support.Type: GrantFiled: September 15, 2016Date of Patent: April 3, 2018Assignee: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Publication number: 20170281756Abstract: Tissue injury prompts the release of a number of proalgesic molecules that induce acute and chronic pain by sensitizing pain-sensing neurons (nociceptors) to heat and mechanical stimuli. In contrast, many proalgesics have no effect on cold sensitivity, or can inhibit cold-sensitive neurons and diminish cooling-mediated pain-relief (analgesia). Nonetheless, cold pain (allodynia) is prevalent in many inflammatory and neuropathic pain settings, with little known of the mechanisms promoting pain versus those dampening analgesia. This disclosure establishes provides methods and compositions to treat cold allodynia induced by inflammation, nerve injury, and chemotherapeutics. One such therapy is the administration of antibodies against the GFR?3 ligand, artemin.Type: ApplicationFiled: February 27, 2017Publication date: October 5, 2017Inventor: David D. McKemy
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Publication number: 20170002053Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. In some embodiments, an isolated or recombinant CMR1 polypeptide is directly or indirectly attached to a detectable label or fused to a second polypeptide. In some embodiments, an isolated or recombinant CMR1 polypeptide is directly or indirectly bound to a solid support.Type: ApplicationFiled: September 15, 2016Publication date: January 5, 2017Inventors: David JULIUS, David D. Mckemy, Werner M. Neuhausser
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Patent number: 9464130Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: GrantFiled: May 4, 2015Date of Patent: October 11, 2016Assignee: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Publication number: 20150307584Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: ApplicationFiled: May 4, 2015Publication date: October 29, 2015Inventors: DAVID JULIUS, DAVID D. MCKEMY, WERNER M. NEUHAUSSER
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Patent number: 9063125Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: GrantFiled: April 8, 2014Date of Patent: June 23, 2015Assignee: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Publication number: 20140287497Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: ApplicationFiled: April 8, 2014Publication date: September 25, 2014Applicant: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Patent number: 8728757Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: GrantFiled: May 24, 2013Date of Patent: May 20, 2014Assignee: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Publication number: 20130315833Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: ApplicationFiled: May 24, 2013Publication date: November 28, 2013Applicant: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Patent number: 8470545Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: GrantFiled: December 29, 2011Date of Patent: June 25, 2013Assignee: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Patent number: 8361733Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: GrantFiled: October 14, 2010Date of Patent: January 29, 2013Assignee: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Publication number: 20120100076Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: ApplicationFiled: December 29, 2011Publication date: April 26, 2012Applicant: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Publication number: 20110053137Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: ApplicationFiled: October 14, 2010Publication date: March 3, 2011Applicant: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Patent number: 7838253Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: GrantFiled: February 15, 2008Date of Patent: November 23, 2010Assignee: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Patent number: 7834150Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: GrantFiled: February 15, 2008Date of Patent: November 16, 2010Assignee: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Publication number: 20080242841Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: ApplicationFiled: February 15, 2008Publication date: October 2, 2008Applicant: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Publication number: 20080241872Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: ApplicationFiled: February 15, 2008Publication date: October 2, 2008Applicant: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Patent number: 7371841Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: GrantFiled: January 27, 2003Date of Patent: May 13, 2008Assignee: Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser
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Publication number: 20030219834Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.Type: ApplicationFiled: January 27, 2003Publication date: November 27, 2003Applicant: The Regents of the University of CaliforniaInventors: David Julius, David D. McKemy, Werner M. Neuhausser