Patents by Inventor David D. Newbold

David D. Newbold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10675602
    Abstract: The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: June 9, 2020
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. DuBose, Douglas L. Millard
  • Publication number: 20190262791
    Abstract: The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
    Type: Application
    Filed: May 7, 2019
    Publication date: August 29, 2019
    Applicant: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. DuBose, Douglas L. Millard
  • Patent number: 10300443
    Abstract: The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: May 28, 2019
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. DuBose, Douglas L. Millard
  • Publication number: 20170333861
    Abstract: The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
    Type: Application
    Filed: August 7, 2017
    Publication date: November 23, 2017
    Applicant: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. DuBose, Douglas L. Millard
  • Patent number: 9724664
    Abstract: The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: August 8, 2017
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. Dubose, Douglas L. Millard
  • Publication number: 20170067801
    Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 9, 2017
    Applicant: Bend Research, Inc.
    Inventors: David D. Newbold, Douglas L. Millard, Erwin Y. Yu, Paul T. Jeffers, Jeffrey W. Weber
  • Patent number: 9499782
    Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: November 22, 2016
    Assignee: Bend Research, Inc.
    Inventors: David D. Newbold, Douglas L. Millard, Erwin Y. Yu, Paul T. Jeffers, Jeffrey W. Weber
  • Patent number: 9358478
    Abstract: A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: June 7, 2016
    Assignee: Bend Research, Inc.
    Inventors: Daniel E. Dobry, James M. Mullin, Douglas L. Millard, Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. Dubose
  • Patent number: 9248584
    Abstract: The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: February 2, 2016
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. DuBose, Douglas L. Millard
  • Publication number: 20150273354
    Abstract: A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
    Type: Application
    Filed: June 12, 2015
    Publication date: October 1, 2015
    Applicant: BEND RESEARCH, INC.
    Inventors: Daniel E. Dobry, James M. Mullin, Douglas L. Millard, Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. Dubose
  • Patent number: 9084976
    Abstract: A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: July 21, 2015
    Assignee: Bend Research, Inc.
    Inventors: Daniel E. Dobry, James M. Mullin, Douglas L. Millard, Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. Dubose
  • Publication number: 20140087413
    Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
    Type: Application
    Filed: May 4, 2012
    Publication date: March 27, 2014
    Applicant: Bend Research, Inc.
    Inventors: David D. Newbold, Douglas L. Millard, Erwin Y. Yu, JR., Paul T. Jeffers, Jeffrey W. Weber
  • Publication number: 20130193598
    Abstract: The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.
    Type: Application
    Filed: September 22, 2011
    Publication date: August 1, 2013
    Applicant: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. DuBose, Douglas L. Millard
  • Publication number: 20130165371
    Abstract: A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
    Type: Application
    Filed: September 1, 2011
    Publication date: June 27, 2013
    Applicant: BEND RESEARCH, INC.
    Inventors: Daniel E. Dobry, James M. Mullin, Douglas L. Millard, Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. Dubose
  • Publication number: 20120015924
    Abstract: The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
    Type: Application
    Filed: March 19, 2010
    Publication date: January 19, 2012
    Inventors: Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. Dubose, Douglas L. Millard
  • Patent number: 7625507
    Abstract: Reduced levels of drug degradation in drug-containing multiparticulates are obtained by an extrusion/melt-congeal process.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: December 1, 2009
    Assignee: Pfizer Inc.
    Inventors: Roderick J. Ray, Leah E. Appel, David D. Newbold, Dwayne T. Friesen, Scott B. McCray, David K. Lyon, James B. West, Marshall D. Crew, Joshua R. Shockey
  • Patent number: 7030338
    Abstract: A laser drilling system forms an opening in the coating of a pharmaceutical dosage form and includes an orienting assembly to correctly orient dosage forms, a debris removal assembly to reduce buildup of and reduce exposure to drilling debris and a quality control assembly to verify that the opening formed conforms to predetermined specifications.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: April 18, 2006
    Assignee: Pfizer, Inc.
    Inventors: Mark S. Carruthers, Christopher D. Craig, Douglas L. Millard, David D. Newbold, Kenny R. Spence, Avinash G. Thombre
  • Patent number: 6059857
    Abstract: A system for the ultrapurification of organic solvents comprising (1) a membrane-based vapor permeation step for selective removal of water vapor from the solvent, wherein a countercurrent sweep stream is used that has a particular partial pressure of water vapor, (2) a filtration step for selective removal of particulates, and (3) an ion exchange step for selective removal of ionic species.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: May 9, 2000
    Assignee: Bend Research, Inc.
    Inventors: Roderick J. Ray, David D. Newbold, Dwayne T. Friesen, Scott B. McCray, Lori A. Ray
  • Patent number: 5843209
    Abstract: Membrane-based vapor permeation system for selective removal of a vapor from a fluid feed stream, wherein a countercurrent sweep stream is used that has a particular partial pressure of the vapor to be removed.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: December 1, 1998
    Assignee: Bend Research, Inc.
    Inventors: Roderick J. Ray, David D. Newbold, Dwayne T. Friesen, Scott B. McCray
  • Patent number: 5753008
    Abstract: A vapor permeation method and apparatus for removing a vapor from a vaporous feed stream, the method and apparatus utilizing highly solvent-resistant composite hollow fiber membranes and a permeate flow countercurrent to the feed flow, wherein the support of the composite membrane is formed by solution casting and has been rendered sufficiently solvent-resistant by a post-casting step to retain at least 20 of its burst pressure when soaked in the solvent used to cast the support.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: May 19, 1998
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, Scott B. McCray, David D. Newbold, Roderick J. Ray