Patents by Inventor David D. Roberts

David D. Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic kit and diagnostic method utilizing carbohydrate receptors
    Patent number: 5225330
    Abstract: A diagnostic kit for detecting the presence of microorganisms, comprising an insoluble substrate; and a carbohydrate receptor immobilized on the insoluble substrate, the carbohydrate receptor being capable of adsorbing microorganisms; and a labelled reagent useful for detecting the presence of microorganisms bound to the carbohydrate receptors and a method for detecting the presence of specified microorganisms in a sample, which comprises contacting a sample to be tested with carbohydrate receptors immobilized on an insoluble substrate; and determining the extent of binding of microorganisms in the sample to the carbohydrate receptors by use of a labelled reagent.
    Type: Grant
    Filed: October 5, 1989
    Date of Patent: July 6, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Victor Ginsburg, Howard C. Krivan, David D. Roberts
  • Carbohydrate receptor for bacteria and method for use thereof
    Patent number: 5217715
    Abstract: The invention is a carbohydrate receptor for pathogenic bacteria. The receptor is a purified carbohydrate compound that is a member selected from the group consisting of fucosyl-asialo GM1, asialo GM1, and asialo GM2. The invented receptor can be included in a composition having a pharmaceutically acceptable carrier. The invention includes methods for purifying, detecting, or removing bacteria from diseased tissue. The applicants have discovered a carbohydrate receptor for a variety of different species of disease-producing bacteria. The structure of the receptor is N-acetylgalactosamine-beta-1-4-galactose-beta-1-4-glucose, abreviated GalNAc.beta.1-4Gal.beta.1-4Glc. The receptor is present in human and animal tissues as complex molecules and can serve as the attachment site for bacterial infection. For example, fucosyl-asialo GM1, asialo GM1, and asialo GM2 are three biological molecules which occur in cell membranes and contain the carbohydrate receptor.
    Type: Grant
    Filed: August 1, 1988
    Date of Patent: June 8, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Howard C. Krivan, Ginsburg Victor, David D. Roberts
  • Adhesion of Mycoplasma pneumoniae and Mycoplasma hominus to sulfatide
    Patent number: 5089479
    Abstract: The invention is a carbohydrate receptor for Mycoplasma pneumoniae and Mycoplasma hominus and its use to detect mycoplasma in biological fluids and diseased tissue and cells. The receptor can be included in a composition having a pharmaceutically acceptable carrier. Methods are provided for purifying, detecting, or removing mycoplasma from diseased tissue or fluids. The receptor includes sulfatides, dextran sulfate, sialyloligosaccharides, and mixtures thereof.
    Type: Grant
    Filed: November 28, 1988
    Date of Patent: February 18, 1992
    Inventors: Howard C. Krivan, Victor Ginsburg, David D. Roberts