Abstract: A method for detecting a change in a neurological condition in a subject is provided herein. The method includes delivering electrical stimulation to the subject’s brain, measuring a cortical reverberation response to the electrical stimulation, analyzing characteristics of the measured cortical reverberation response, and determining a likelihood of change in the neurological condition in the subject based on changes in the analyzed characteristics of the cortical reverberation response over time. The electrical stimulation may include low-intensity electrical pulses delivered at regular intervals. The analyzed characteristics may include amplitude, duration, or decay slope of the cortical reverberation response. A progressive decline in these characteristics over time may indicate autoregulatory failure or other neurological condition changes in the subject.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: User-specific neurostimulation settings are efficiently determined and optimized based on an optimized set of population-based neurostimulation settings. The population data are clustered and a set of test settings for a new user are selected as settings that efficiently discriminate between the clusters. User preference of the test settings are used to map the user to a particular cluster of settings, which can be used to determine user-specific neurostimulation settings. The user-based settings can be iteratively updated and/or optimized using information from the population data, such as by using average preference score surfaces in the population data to identify and/or filter new test settings for the user.

Abstract: Methods of processing substrates in a processing tool having a plurality of miniature modular charged particle devices include obtaining a first digital image of a feature of a movable object using an optical inspection system; determining a first position of the movable object based on the digital image using readings from a first plurality of position sensors having a first accuracy; based on the first position, and a predetermined dimension of the processing tool, moving the movable object such that the feature is within an exposure area of a charged particle device; obtaining a second digital image of the feature using the charged particle device; and determining a second position of the movable object based on the second digital image and readings from a second plurality of position sensors. Other methods include using a second charged particle device to perform a print plan when a first device is not operated.

Abstract: A method includes positioning an ultrasound transducer system to direct focused ultrasound energy into a subject's tissue, configuring the ultrasound transducer system to direct focused ultrasound energy into target nervous system tissue in the subject's tissue configured to cause heating of the target nervous system tissue to reversibly modulate neural activity, and delivering focused ultrasound energy to target nervous system tissue based on the configured ultrasound transducer system. A system includes a dual-mode ultrasound transducer and a controller configured to deliver focused ultrasound energy.

Abstract: A neurostimulation system includes a plurality of stimulation electrodes, a plurality of recording electrodes, a waveform generator in electrical communication with the plurality of stimulation electrodes, and one or more computing devices in electrical communication with the plurality of recording electrodes and the waveform generator. The one or more computing devices cause the waveform generator to electrically excite the plurality of stimulation electrodes of the plurality of stimulation electrodes. After electrically exciting the stimulation electrodes, a neural signal is received from the plurality of recording electrodes. The neural signal is determined to be an electrically evoked compound action potential (“ECAP”) by determining one or more features of the neural signal. One or more stimulation parameters are determined based on one or more characteristics of the ECAP.

Abstract: User-specific neurostimulation settings are efficiently determined and optimized based on an optimized set of population-based neurostimulation settings. The population data are clustered and a set of test settings for a new user are selected as settings that efficiently discriminate between the clusters. User preference of the test settings are used to map the user to a particular cluster of settings, which can be used to determine user-specific neurostimulation settings. The user-based settings can be iteratively updated and/or optimized using information from the population data, such as by using average preference score surfaces in the population data to identify and/or filter new test settings for the user.

Abstract: Described here are systems and methods for testing neurostimulation settings and measuring their effects on neural activity, which may then be used to select subject-specific neurostimulation settings. In general, the present disclosure provides systems and methods that utilize neural recordings to help determine the neurostimulation settings that maximally reduce a particular neural activity.

Abstract: Neurostimulation, such as electrical and/or magnetic neurostimulation, is controlled using an adaptive real-time state space (ARTISTS) control framework to determine and/or adjust stimulation settings (e.g., stimulation waveforms). The ARTISTS control framework generally includes an adaptive autoregressive model of the nervous system's response to stimulation, an amended Kalman filter to estimate the state and coefficients of the autoregressive model, and a linear quadratic regulator to determine the stimulation waveform to be delivered.

Abstract: Precision functional mapping (PFM) is used to inform the planning, guidance, and/or monitoring of neuromodulation, including non-invasive brain stimulation, deep brain stimulation, prefrontal cortical stimulation, intracranial electrical stimulation, focused ultrasound-based neuromodulation, pharmacological-based neuromodulation, or the like.

Abstract: A medical device is controlled based in part on a Bayesian preference learning-based optimization of the control parameters of the device. The Bayesian preference learning-based optimization is implemented to identify personalized optimal control parameters based on user preference for control parameter settings. The Bayesian preference learning-based optimization provides automatic tuning of the control parameters of the medical device based on feedback data, such as user response data, to achieve a user-specific therapy or effect.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: An implantable blood pressure monitor has two or more elements configured to wrap at least part way around a blood vessel. Changes in pressure within the blood vessel may be sensed by detecting movements of the elements or forces applied to the elements. A blood pressure monitor may be implanted without surgery. The blood pressure monitor may transmit real time blood pressure information to a receiver by wireless data transmission.

Abstract: User-specific neurostimulation settings are efficiently determined and optimized based on an optimized set of population-based neurostimulation settings. The population data are clustered and a set of test settings for a new user are selected as settings that efficiently discriminate between the clusters. User preference of the test settings are used to map the user to a particular cluster of settings, which can be used to determine user-specific neurostimulation settings. The user-based settings can be iteratively updated and/or optimized using information from the population data, such as by using average preference score surfaces in the population data to identify and/or filter new test settings for the user.

Abstract: A neuromodulation system, especially a neurostimulation system, for treating a patient, especially for enhancing at least one autonomous function such as blood circulation and/or respiration, wherein the system comprises: at least one signal input module, which is configured to receive at least one or more signals being indicative for blood circulation, especially being indicative for pulse and/or blood pressure, at least one control module, wherein the control module is connected to the signal input module, wherein the control module is configured to adapt the neurostimulation provided by the neuromodulation system on the basis of the signal(s) received by the signal input module.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: A method includes positioning an ultrasound transducer system to direct focused ultrasound energy into a subject's tissue, configuring the ultrasound transducer system to direct focused ultrasound energy into target nervous system tissue in the subject's tissue configured to cause heating of the target nervous system tissue to reversibly modulate neural activity, and delivering focused ultrasound energy to target nervous system tissue based on the configured ultrasound transducer system. A system includes a dual-mode ultrasound transducer and a controller configured to deliver focused ultrasound energy.