Abstract: Described here are systems and methods for testing neurostimulation settings and measuring their effects on neural activity, which may then be used to select subject-specific neurostimulation settings. In general, the present disclosure provides systems and methods that utilize neural recordings to help determine the neurostimulation settings that maximally reduce a particular neural activity.

Abstract: Neurostimulation, such as electrical and/or magnetic neurostimulation, is controlled using an adaptive real-time state space (ARTISTS) control framework to determine and/or adjust stimulation settings (e.g., stimulation waveforms). The ARTISTS control framework generally includes an adaptive autoregressive model of the nervous system's response to stimulation, an amended Kalman filter to estimate the state and coefficients of the autoregressive model, and a linear quadratic regulator to determine the stimulation waveform to be delivered.

Abstract: Precision functional mapping (PFM) is used to inform the planning, guidance, and/or monitoring of neuromodulation, including non-invasive brain stimulation, deep brain stimulation, prefrontal cortical stimulation, intracranial electrical stimulation, focused ultrasound-based neuromodulation, pharmacological-based neuromodulation, or the like.

Abstract: A medical device is controlled based in part on a Bayesian preference learning-based optimization of the control parameters of the device. The Bayesian preference learning-based optimization is implemented to identify personalized optimal control parameters based on user preference for control parameter settings. The Bayesian preference learning-based optimization provides automatic tuning of the control parameters of the medical device based on feedback data, such as user response data, to achieve a user-specific therapy or effect.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: An implantable blood pressure monitor has two or more elements configured to wrap at least part way around a blood vessel. Changes in pressure within the blood vessel may be sensed by detecting movements of the elements or forces applied to the elements. A blood pressure monitor may be implanted without surgery. The blood pressure monitor may transmit real time blood pressure information to a receiver by wireless data transmission.

Abstract: User-specific neurostimulation settings are efficiently determined and optimized based on an optimized set of population-based neurostimulation settings. The population data are clustered and a set of test settings for a new user are selected as settings that efficiently discriminate between the clusters. User preference of the test settings are used to map the user to a particular cluster of settings, which can be used to determine user-specific neurostimulation settings. The user-based settings can be iteratively updated and/or optimized using information from the population data, such as by using average preference score surfaces in the population data to identify and/or filter new test settings for the user.

Abstract: A neuromodulation system, especially a neurostimulation system, for treating a patient, especially for enhancing at least one autonomous function such as blood circulation and/or respiration, wherein the system comprises: at least one signal input module, which is configured to receive at least one or more signals being indicative for blood circulation, especially being indicative for pulse and/or blood pressure, at least one control module, wherein the control module is connected to the signal input module, wherein the control module is configured to adapt the neurostimulation provided by the neuromodulation system on the basis of the signal(s) received by the signal input module.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: A guide insert for use in insertion of a medical tool into a patient and an associated method of using the guide insert in a medical device are disclosed. The guide insert includes a base sized and shaped to be inserted into an opening of a grid of the medical device, a rotatable structure configured to fit on or within the base, and a securing cap configured to secure the rotatable structure to the base and to prevent rotation of the rotatable structure when secured.

Abstract: A device for testing a rotor blade of an aircraft. The device is configured to receive and secure a shaft of the rotor blade. Once secured, the device is configured to allow for inputting combined loads and bending moments into the rotor blade to simulate the rotor blade behavior in flight. A testing assembly is also disclosed that includes the device and the rotor blade and methods of use that provide for testing the rotor blade.

Abstract: A printing system includes a substrate support, a printhead assembly positioned facing the substrate support, and an imager. The printhead assembly includes a plurality of dispensing nozzles extending in an ejection direction towards the substrate support and a plurality of marks. The imager is movable relative to the printhead assembly and oriented in a direction opposite to the ejection direction for capturing at least one image including the plurality of marks indicating positions of the plurality of dispensing nozzles in the printhead assembly.

Abstract: A method includes positioning an ultrasound transducer system to direct focused ultrasound energy into a subject's tissue, configuring the ultrasound transducer system to direct focused ultrasound energy into target nervous system tissue in the subject's tissue configured to cause heating of the target nervous system tissue to reversibly modulate neural activity, and delivering focused ultrasound energy to target nervous system tissue based on the configured ultrasound transducer system. A system includes a dual-mode ultrasound transducer and a controller configured to deliver focused ultrasound energy.

Abstract: A device for testing a rotor blade of an aircraft. The device is configured to receive and secure a shaft of the rotor blade. Once secured, the device is configured to allow for inputting combined loads and bending moments into the rotor blade to simulate the rotor blade behavior in flight. A testing assembly is also disclosed that includes the device and the rotor blade and methods of use that provide for testing the rotor blade.

Abstract: An extraventricular drain system can include a catheter. The catheter can have a shaft including a proximal end and a distal end, a lumen extended along a length of the catheter, and a drain located on the shaft. The drain can be fluidly coupled with the lumen. In an example, an electrode can be located along the shaft at an axial location. A reference contact can be located on the shaft at an axial location further from the distal end than the electrode. The electrode and the reference contact can be configured for electrical communication with a processing unit. In a further example, a first pressure port and a second pressure port can be located at the distal end and have different respective axial locations and respective radial locations. The first and second pressure ports can be in fluid communication with a first and second pressure sensors respectively.

Abstract: The present approach relates to the manufacture and use of guides inserts for use in the insertion of certain tools into a patient. Guide inserts as discussed herein allow tools to be inserted at arbitrary, including non-perpendicular, orientations relative to a grid in which the guide insert is positioned. Both customizable and configurable guide inserts are contemplated and described.

Abstract: The system and method of the invention pertains to an MR-guided breast biopsy procedure, specifically as to quickly identifying the biopsy location. More particularly, the system utilizes a diagnostic imaging modality such as magnetic resonance imaging (MRI) to locate one or more lesions in a human breast. Non-rigid registration between uncompressed screening images (where the lesion has been previously identified) and the compressed biopsy images enables easier identification of the biopsy site, hence shortening the biopsy procedure.

Abstract: An imaging system includes an imager adapted to obtain an image of a desired region of interest of a subject and a coil positioned on the desired region of interest of the subject. The coil includes a plurality of markings disposed at a plurality of locations on the coil. The imaging system also includes a position indication device having a user interface adapted to receive input from a user indicating which of the plurality of markings corresponds to a desired scan plane of the subject.