Abstract: Provided herein is a topical antibiotic composition that includes an external antibiotic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical antibiotic composition.

Abstract: Provided herein is a topical analgesic composition that includes an external analgesic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical analgesic composition.

Abstract: A product dispensing clock includes a housing and a reservoir arranged in the housing. The reservoir holds a number of dispensable products. A dispenser is arranged in the housing adjacent the reservoir. The dispenser receives at least one of the dispensable products from the reservoir. A collection chamber is defined in the housing. The dispenser dispenses the dispensable products received from the reservoir to the collection chamber for a user to collect the dispensable products. A controller activates the dispenser at a predetermined time interval to dispense the dispensable products to the collection chamber for collection by the user.

Abstract: In some embodiments, virtualization methods for generating a binaural signal in response to channels of a multi-channel audio signal, which apply a binaural room impulse response (BRIR) to each channel including by using at least one feedback delay network (FDN) to apply a common late reverberation to a downmix of the channels. In some embodiments, input signal channels are processed in a first processing path to apply to each channel a direct response and early reflection portion of a single-channel BRIR for the channel, and the downmix of the channels is processed in a second processing path including at least one FDN which applies the common late reverberation. Typically, the common late reverberation emulates collective macro attributes of late reverberation portions of at least some of the single-channel BRIRs. Other aspects are headphone virtualizers configured to perform any embodiment of the method.

Abstract: The invention provides new heteroaromatic compounds having the general formula (I?), or a solvate or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: A product dispensing clock includes a housing and a reservoir arranged in the housing. The reservoir holds a number of dispensable products. A dispenser is arranged in the housing adjacent the reservoir. The dispenser receives at least one of the dispensable products from the reservoir. A collection chamber is defined in the housing. The dispenser dispenses the dispensable products received from the reservoir to the collection chamber for a user to collect the dispensable products. A controller activates the dispenser at a predetermined time interval to dispense the dispensable products to the collection chamber for collection by the user.

Abstract: A product dispensing clock includes a housing and a reservoir arranged in the housing. The reservoir holds a number of dispensable products. A dispenser is arranged in the housing adjacent the reservoir. The dispenser receives at least one of the dispensable products from the reservoir. A collection chamber is defined in the housing. The dispenser dispenses the dispensable products received from the reservoir to the collection chamber for a user to collect the dispensable products. A controller activates the dispenser at a predetermined time interval to dispense the dispensable products to the collection chamber for collection by the user.

Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.

Abstract: Surgical punch tools and methods of using the same are disclosed herein. A surgical punch tool may include a stationary base component having a planar bottom side. The planar bottom side may include one or more posts extending therefrom. Each post may include an associated sharp pin. A movable actuation portion may be configured to move each sharp pin from a non-actuated position within the corresponding post to an actuated position extending through the base component and from the corresponding post.

Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.

Abstract: Surgical punch tools and methods of using the same are disclosed herein. A surgical punch tool may include a stationary base component having a planar bottom side. The planar bottom side may include one or more posts extending therefrom. Each post may include an associated sharp pin. A movable actuation portion may be configured to move each sharp pin from a non-actuated position within the corresponding post to an actuated position extending through the base component and from the corresponding post.

Abstract: A surgical robotic arm (520) for use with an external vision system (512) includes onboard control and at least four degrees of articulation. The robotic arm (520) can position various tools (534) in the surgical theatre responsive to positional feedback from the vision system (512). Exemplary tools (534) include a handpiece (519) that includes a motorized burr or saw, a cutting guide (542) for a handheld saw, and a laser to actively define a resection area for a surgeon. The tool (534) or a reference point on the arm (520) relative to the tool (534) includes fiducial marks to register the position of the tool (534) with the vision system (512). Exemplary tools (534) are especially suited for knee and hip arthroplasty and can be moved under processor or manual control.

Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.

Abstract: Surgical punch tools and methods of using the same are disclosed herein. A surgical punch tool may include a stationary base component having a planar bottom side. The planar bottom side may include one or more posts extending therefrom. Each post may include an associated sharp pin. A movable actuation portion may be configured to move each sharp pin from a non-actuated position within the corresponding post to an actuated position extending through the base component and from the corresponding post.

Abstract: Surgical punch tools and methods of using the same are disclosed herein. A surgical punch tool may include a stationary base component having a planar bottom side. The planar bottom side may include one or more posts extending therefrom. Each post may include an associated sharp pin. A movable actuation portion may be configured to move each sharp pin from a non-actuated position within the corresponding post to an actuated position extending through the base component and from the corresponding post.

Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.

Abstract: A data processing system generates a scorecard analysis that displays multiple scorecard windows, each directed to a specific different perspective on a particular business function. Each perspective may have at least one corresponding objective, and each objective may have at least one corresponding key performance indicator. Each scorecard may include drill down capability from a top level analysis to more detailed information on a perspective, objective, or key performance indicator.

Abstract: A rod handling device includes a pivot rod, first clamp assembly pivotingly coupled to the pivot rod, a second clamp assembly pivotingly coupled to the pivot rod, and at least one locking assembly configured to move between a locked position and an unlocked position. While in the locked position the locking assembly prevents rotation between the first clamp assembly and the second clamp assembly. The rod handling device also includes a biasing member coupled to the pivot rod, the biasing member being configured to urge the locking assembly toward the locked position.

Abstract: A data processing system generates a scorecard analysis that displays multiple scorecard windows, each directed to a specific different perspective on a particular business function. Each perspective may have at least one corresponding objective, and each objective may have at least one corresponding key performance indicator. Each scorecard may include drill down capability from a top level analysis to more detailed information on a perspective, objective, or key performance indicator.