Patents by Inventor David DeTomaso

David DeTomaso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNE CELLS WITH COMBINATION GENE PERTURBATIONS
    Publication number: 20250222103
    Abstract: Provided herein are recombinant nucleic acids that reduce expression of CD5, CBLB, CISH, DGKA, DGKZ, DNMT3A, MAP4K1, NR4A1, PTPN2, TET2, or ZC3H12A and cells comprising such recombinant nucleic acids. Also provided are methods of making and using such cells.
    Type: Application
    Filed: March 14, 2025
    Publication date: July 10, 2025
    Inventors: Adam Litterman, Brenal Singh, John Gagnon, David Detomaso, Ashley Cass, Levi Gray-Rupp, Samuel Williams
  • MODULATION OF A PATHOGENIC PHENOTYPE IN TH1 CELLS
    Publication number: 20240108689
    Abstract: The subject matter disclosed herein is generally directed to pathogenic Th1 cells whose phenotype is dependent on IL-23R signaling. Th1 cell specific therapeutic targets and gene programs are disclosed herein. In particular, inhibition of CD160 reduces Th1 cell pathogenicity.
    Type: Application
    Filed: January 21, 2022
    Publication date: April 4, 2024
    Inventors: Vijay K. Kuchroo, Ramnik Xavier, Mathias Pawlak, David DeTomaso, Nir Yosef