Patents by Inventor David Diller

David Diller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180298031
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Application
    Filed: June 22, 2018
    Publication date: October 18, 2018
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
  • Patent number: 10030034
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: July 24, 2018
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
  • Publication number: 20160347767
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Application
    Filed: January 26, 2016
    Publication date: December 1, 2016
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
  • Patent number: 9266874
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: February 23, 2016
    Assignee: LIGAND PHARMACEUTICALS INCORPORATED
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
  • Patent number: 9001619
    Abstract: Disclosed herein are various embodiments of methods and systems for determining the orientation and direction of first motion of a fault or fracture by optimizing an azimuthally-dependent attribute of signals generated by microseismic sources, comprising: recording microseismic data traces using a of sensors located at a plurality of sensor positions; subdividing the subsurface volume into spatial volumes corresponding to selected time intervals and comprising a plurality of voxels; for each voxel, applying a time shift to the microseismic data traces that is substantially equal to a travel time from each voxel to the corresponding sensor position, and determining for the voxel the orientation and direction of first motion of the fault or fracture corresponding to a maximum value for the voxel of at least one azimuthally-dependent attribute of the microseismic data traces.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: April 7, 2015
    Assignee: Global Microseismic Services, Inc.
    Inventors: David Diller, Barry Fish, Ran Xuan, Charles John Sicking
  • Publication number: 20140155379
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 5, 2014
    Applicant: Ligand Pharmaceuticals Incorporated
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
  • Publication number: 20130100770
    Abstract: Disclosed herein are various embodiments of methods and systems for determining the orientation and direction of first motion of a fault or fracture by optimizing an azimuthally-dependent attribute of signals generated by microseismic sources, comprising: recording microseismic data traces using a of sensors located at a plurality of sensor positions; subdividing the subsurface volume into spatial volumes corresponding to selected time intervals and comprising a plurality of voxels; for each voxel, applying a time shift to the microseismic data traces that is substantially equal to a travel time from each voxel to the corresponding sensor position, and determining for the voxel the orientation and direction of first motion of the fault or fracture corresponding to a maximum value for the voxel of at least one azimuthally-dependent attribute of the microseismic data traces.
    Type: Application
    Filed: October 19, 2011
    Publication date: April 25, 2013
    Applicant: Global Microseismic Services, Inc.
    Inventors: David Diller, Barry Fish, Ran Xuan, Charles John Sicking
  • Publication number: 20110218189
    Abstract: The present invention relates to a pyrrolo[2,3-d]pyrimidin-2-yl-amine derivative according to formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising one or more of said pyrrolo[2,3-d]pyrimidine-2-ylamine derivatives and to their use in therapy, for instance in the treatment of PKC? mediated disorders.
    Type: Application
    Filed: April 8, 2009
    Publication date: September 8, 2011
    Applicant: N.V. ORGANON
    Inventors: Andrew Laird Roughton, Koc-kan Ho, Michael Ohlmeyer, David Diller, Irina Neagu, Celia Kingsbury, Jui-Hsiang Chan, Johannes Petrus, Mmaria Lommerse, Neeltje Miranda Teerhuis, Jacobus Comelis Henricus Maria Wijkmans, Ralf Plate
  • Patent number: 7989459
    Abstract: A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC?. inhibitors, and their methods of use are disclosed. The genus is represented by the formula I: wherein R1 is chosen from nitrogen-attached heterocyclyl, nitrogen-attached substituted heterocyclyl wherein the point of attachment is a nitrogen heteroatom, and R2 is chosen from aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, hetroarylalkyl, and substituted heteroarylalkyl.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: August 2, 2011
    Assignee: Pharmacopeia, LLC
    Inventors: Andrew Roughton, Yajing Rong, Koc Kan Ho, Michael Ohlmeyer, David Diller
  • Patent number: 7919490
    Abstract: The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: April 5, 2011
    Assignee: Wyeth LLC
    Inventors: Irina Neagu, David Diller, Celia Kingsbury, Adolph C. Bohnstedt, Michael J. Ohlmeyer, Vidyadhar Paradkar, Nasrin Ansari
  • Patent number: 7902187
    Abstract: The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: March 8, 2011
    Assignee: Wyeth LLC
    Inventors: Irina Neagu, David Diller, Celia Kingsbury, Adolph C. Bohnstedt, Michael J. Ohlmeyer, Vidyadhar Paradkar, Nasrin Ansari
  • Publication number: 20110046131
    Abstract: A chemical genus of purines, which are useful as PKC? inhibitors, is disclosed.
    Type: Application
    Filed: October 19, 2007
    Publication date: February 24, 2011
    Inventors: Irina Neagu, Andrew Laird Roughton, Koc-Kan Ho, David Diller, Jui-Hsiang Chan, Michael Ohlmeyer, Celia Kingsbury, Johannes Petrus Maria Lommerse, Neeltje Miranda, Jacobus Cornelis Henricus Maria Wijkmans
  • Publication number: 20090281075
    Abstract: A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC? inhibitors, and their methods of use are disclosed.
    Type: Application
    Filed: November 7, 2008
    Publication date: November 12, 2009
    Applicant: PHARMACOPEIA, INC.
    Inventors: Andrew L. Roughton, Yajing Rong, Koc-Kan Ho, Michael J. Ohlmeyer, David Diller, Ray Jui-Hsiang Chan, Gaifa Lai
  • Publication number: 20090069289
    Abstract: The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection.
    Type: Application
    Filed: August 22, 2008
    Publication date: March 12, 2009
    Applicant: PHARMACOPEIA, INC.
    Inventors: Irina Neagu, David Diller, Celia Kingsbury, Adolph C. Bohnstedt, Michael J. Ohlmeyer, Vidyadhar Paradkar, Ansari Nasrin
  • Publication number: 20080214580
    Abstract: The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection.
    Type: Application
    Filed: October 4, 2007
    Publication date: September 4, 2008
    Applicant: PHARMACOPEIA, INC.
    Inventors: Irina Neagu, David Diller, Celia Kingsbury, Adolph C. Bohnstedt, Michael J. Ohlmeyer, Vidyadhar Paradkar, Nasrin Ansari
  • Publication number: 20080085909
    Abstract: A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC? inhibitors, and their methods of use are disclosed.
    Type: Application
    Filed: February 2, 2007
    Publication date: April 10, 2008
    Applicant: Pharmacopeia Drug Discovery, Inc.
    Inventors: Andrew Roughton, Yajing Rong, Koc Kan Ho, Michael Ohlmeyer, David Diller
  • Publication number: 20080032971
    Abstract: Compounds of the formula are disclosed as Mnk2 inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.
    Type: Application
    Filed: March 9, 2007
    Publication date: February 7, 2008
    Applicant: PHARMACOPEIA DRUG DISCOVERY, INC.
    Inventors: Andrew Cole, Marc-Raleigh Brescia, Joan Zhang, Zahid Hussain, David Diller, Axel Metzger, Gulzar Ahmed, Ian Henderson
  • Publication number: 20070078605
    Abstract: A high-throughput molecular docking facility is presented for screening combinatorial libraries to identify binding ligands and ultimately pharmaceutical compounds. The facility employs a pre-docking conformational search to generate multiple solution conformations of a ligand. The molecular docking facility includes: generating a binding site image of the protein, the binding site image having multiple hot spots; matching hot spots of the binding site image to atoms in at least one solution conformation of the multiple solution conformations of the ligand to obtain at least one ligand position relative to the protein in a ligand-protein complex formation; and optimizing the at least one ligand position while allowing translation, orientation and rotatable bonds of the ligand to vary, and while holding the protein fixed.
    Type: Application
    Filed: April 21, 2006
    Publication date: April 5, 2007
    Inventors: David Diller, Kenneth Merz
  • Publication number: 20060276488
    Abstract: N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-? expression utilizing compounds of the present invention are also disclosed.
    Type: Application
    Filed: July 12, 2006
    Publication date: December 7, 2006
    Inventors: Gulzar Ahmed, Axel Metzger, Ian Henderson, David Diller, Jun Wen, Stephen Wrobleski, Katerina Leftheris, Chunjian Liu
  • Publication number: 20060206269
    Abstract: A set of molecules, the members of which have the same type of biological activity, are represented as one-dimensional strings of atoms. The one-dimensional strings of all members of the set are aligned, in order to obtain a multiple alignment profile of a consensus active compound. The one-dimensional multiple alignment profile is used in deriving a one-dimensional QSAR model to identify other compounds likely to have the same biological activity, and also may be used to derive a three-dimensional multiple alignment profile of the molecules in the set.
    Type: Application
    Filed: November 21, 2005
    Publication date: September 14, 2006
    Applicant: Pharmacopeia Drug Discovery, Inc.
    Inventors: David Diller, Norman Wang, Robert DeLisle, Andrei Anghelescu