Patents by Inventor David Dodds

David Dodds has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12258333
    Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Grant
    Filed: October 20, 2023
    Date of Patent: March 25, 2025
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Elizabeth Mary Beck, Steven John Durrant, Sarah Skerratt, Robert Pullin, Gorka Etxebarria Jardi, David Matthew Shaw, Nadia M. Ahmad, Christopher Wray, Anisa Nizarali Virani, Kiri North, James Dodd, Michael Edward O'Donnell, Bhairavi Galan, Ronald Marcellus Knegtel, Ewa Iwona Chudyk, Joanne Louise Pinder, Stephen Andrew Thomson, Lidio Marx Carvalho Meireles, Dean Stamos, Yvonne Schmidt, Joseph Pontillo, Sara S. Hadida Ruah, Timothy Donald Neubert, Dennis James Hurley, Jinglan Zhou
  • Patent number: 12259393
    Abstract: “The present disclosure provides methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers having an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Grant
    Filed: April 4, 2024
    Date of Patent: March 25, 2025
    Assignee: Glyphic Biotechnologies, Inc.
    Inventors: Asmamaw Wassie, Daniel Masao Estandian, Andrew John Price, Boyang Hua, Joshua Young Cynming Yang, David Dodd, Gerardo Fabian Delgado, Elaine Jean Su
  • Patent number: 12259394
    Abstract: The present disclosure provides methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers having an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Grant
    Filed: April 4, 2024
    Date of Patent: March 25, 2025
    Assignee: Glyphic Biotechnologies, Inc.
    Inventors: Asmamaw Wassie, Daniel Masao Estandian, Andrew John Price, Boyang Hua, Joshua Young Cynming Yang, David Dodd, Gerardo Fabian Delgado, Elaine Jean Su
  • Publication number: 20240344057
    Abstract: Disclosed herein are methods and compositions comprising a polymerase and a phosphorylated nucleoside, wherein the polymerase and the nucleoside are covalently linked by a cleavable linker at the terminal phosphate group. Further disclosed herein are enzymatic polynucleotide synthesis using polymerase and nucleotide conjugation strategies.
    Type: Application
    Filed: April 26, 2024
    Publication date: October 17, 2024
    Inventors: Jeremy LACKEY, David DODD
  • Publication number: 20240337661
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Application
    Filed: April 4, 2024
    Publication date: October 10, 2024
    Inventors: Daniel Masao ESTANDIAN, Asmamaw WASSIE, Andrew John PRICE, Boyang HUA, Joshua Young Cynming YANG, David DODD, Gerardo Fabian DELGADO, Elaine Jean SU
  • Publication number: 20240337660
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Application
    Filed: April 4, 2024
    Publication date: October 10, 2024
    Inventors: Daniel Masao ESTANDIAN, Asmamaw WASSIE, Andrew John PRICE, Boyang HUA, Joshua Young Cynming YANG, David DODD, Gerardo Fabian DELGADO, Elaine Jean SU
  • Publication number: 20240319468
    Abstract: An optical system is provided that includes a conduit fitting, a first connector, a first conduit, a first ferrule and a first nut. The conduit fitting includes a receptacle. The first connector is disposed within the receptacle. The first connector includes a first bore, a first counterbore and a first port radially outboard of the first bore. The first conduit includes a first optics line and a first fluid passage. The first conduit projects longitudinally into the first counterbore and is attached to the first connector. The first optics line projects longitudinally into the first bore. The first fluid passage is fluidly coupled with the first port. The first ferrule circumscribes the first connector. The first nut is threaded onto the conduit fitting and is configured to wedge the first ferrule radially between the first connector and the conduit fitting.
    Type: Application
    Filed: March 21, 2023
    Publication date: September 26, 2024
    Inventors: Eli Warren, David Dodds, Bryan J. Hackett, Alan E. Ingram, Michael F. Sabol, Nicholas O'Gara, Kyle Hardwick
  • Patent number: 12095729
    Abstract: A method of configuring a filter to perform pattern matching against input data is provided. The method includes receiving one or more rules, each rule including one or more field specifiers, each field specifier including a value specifier that specifies a value to be matched and a location specifier that specifies a location in the input data. For each rule of the one or more rules an empty buffer is initialized. For each field specifier the value specified by the field specifier is appended to the buffer, and the buffer contents are inserted into contents of a probabilistic data structure representing all of the field specifiers of the rule. The probabilistic data structure is configured to receive a query that includes query buffer contents determined from the input data and respond with a match status of probably present based on a predetermined probability, or definitely not present.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: September 17, 2024
    Assignee: NETSCOUT SYSTEMS TEXAS, LLC
    Inventors: Brian St. Pierre, Timothy David Dodd, Steinthor Bjarnason
  • Patent number: 11970697
    Abstract: Disclosed herein are methods and compositions comprising a polymerase and a phosphorylated nucleoside, wherein the polymerase and the nucleoside are covalently linked by a cleavable linker at the terminal phosphate group. Further disclosed herein are enzymatic polynucleotide synthesis using polymerase and nucleotide conjugation strategies.
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: April 30, 2024
    Assignee: Twist Bioscience Corporation
    Inventors: Jeremy Lackey, David Dodd
  • Publication number: 20240124918
    Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
    Type: Application
    Filed: March 27, 2023
    Publication date: April 18, 2024
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
  • Publication number: 20240084351
    Abstract: Provided herein are composition and process for using a device for the reduction of the oxidized state of phosphorylated or non-phosphorylated nicotinamide adenine dinucleotide to the reduced state, using a catalyst to enable the reduction of the oxidized form of the phosphorylated or non-phosphorylated nicotinamide adenine dinucleotide by hydrogen, and methods for providing the hydrogen.
    Type: Application
    Filed: January 31, 2022
    Publication date: March 14, 2024
    Applicant: BIOCHEMINSIGHTS, INC.
    Inventors: David Dodds, William Armiger, Benedict Schwegler
  • Publication number: 20240073184
    Abstract: A method of configuring a filter to perform pattern matching against input data is provided. The method includes receiving one or more rules, each rule including one or more field specifiers, each field specifier including a value specifier that specifies a value to be matched and a location specifier that specifies a location in the input data. For each rule of the one or more rules an empty buffer is initialized. For each field specifier the value specified by the field specifier is appended to the buffer, and the buffer contents are inserted into contents of a probabilistic data structure representing all of the field specifiers of the rule. The probabilistic data structure is configured to receive a query that includes query buffer contents determined from the input data and respond with a match status of probably present based on a predetermined probability, or definitely not present.
    Type: Application
    Filed: August 30, 2022
    Publication date: February 29, 2024
    Applicant: NetScout Systems Texas, LLC
    Inventors: Brian St. Pierre, Timothy David Dodd, Steinthor Bjarnason
  • Publication number: 20240068027
    Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
    Type: Application
    Filed: March 22, 2023
    Publication date: February 29, 2024
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
  • Publication number: 20240035081
    Abstract: Methods of sequencing molecules based on luminescence lifetimes and/or intensities are provided. In some aspects, methods of sequencing nucleic acids involve determining the luminescence lifetimes, and optionally luminescence intensities, of a series of luminescently labeled nucleotides incorporated during a nucleic acid sequencing reaction. In some aspects, the disclosure provides compositions comprising luminescently labeled nucleotides.
    Type: Application
    Filed: September 23, 2022
    Publication date: February 1, 2024
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
  • Publication number: 20230407247
    Abstract: The present disclosure relates generally to the use of a plastic and/or pliable, sterile container, such as a bag, bottle, or pouch as a sterile enclosure for the culturing of plant cells in a liquid medium.
    Type: Application
    Filed: May 17, 2023
    Publication date: December 21, 2023
    Inventors: Luciano Luiz Bueno, Shreyas Joshi, Franklin Magnum, David Dodds
  • Publication number: 20230399668
    Abstract: The present disclosure provides in vitro methods for producing cotton fiber, including methods using cotton varietals the were discovered to be particularly amendable for use in the presently disclosed in vitro methods of cotton fiber production.
    Type: Application
    Filed: October 26, 2021
    Publication date: December 14, 2023
    Inventors: Luciano Luiz Bueno, Paula Maria Elbl, David Dodds, Anat Tewari, Leticia Silveira De Sousa Luz
  • Publication number: 20230175062
    Abstract: Provided herein are compositions, devices, systems and methods for single molecule sensing. Further provided are devices for nucleic acid sequencing. The compositions, devices, systems and methods described herein provide improved retrieval of biomolecule-based information.
    Type: Application
    Filed: December 7, 2022
    Publication date: June 8, 2023
    Inventors: Jeremy LACKEY, Andres FERNANDEZ, David DODD, Alexander GORYAYNOV
  • Publication number: 20230158469
    Abstract: Provided herein are compositions, devices, systems and methods for DNA oligomer synthesis. Further provided are devices comprising addressable electrodes controlling polynucleotide synthesis (deprotection, extension, or cleavage, etc.). The compositions, devices, systems and methods described herein provide improved synthesis, storage, density, and retrieval of biomolecule-based information.
    Type: Application
    Filed: October 31, 2022
    Publication date: May 25, 2023
    Inventors: Jeremy LACKEY, David DODD, Stefan PITSCH
  • Patent number: 11655504
    Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: May 23, 2023
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
  • Patent number: 11613772
    Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: March 28, 2023
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd