Abstract: A catheter assembly comprises a catheter, with a proximal end for insertion into the body and a distal end, and a wetting mechanism comprising a base and a body. The body comprises a fluid reservoir. The base and body are rotatable with respect to one another to define a first configuration and a second configuration of the wetting mechanism. The fluid reservoir comprises an opening configured to allow fluid to exit the fluid reservoir to wet the catheter when in the second configuration. The fluid reservoir comprises a sealing element configured to provide a fluid-tight seal between the opening and the base when in the first configuration. The sealing element is resiliently deformed by compression between the base and body and inhibits inadvertent rotation of the base with respect to the body. The catheter is preferably an intermittent male urinary catheter. The sealing element is preferably an O-ring.

Abstract: A catheter assembly comprises a catheter, a sleeve and a wetting mechanism. The catheter comprising a proximal end for insertion into the body and a distal end. The sleeve is configured to enclose the catheter, and the wetting mechanism is arranged at the proximal end of the catheter. The wetting mechanism comprises a base and a body: the body comprises a fluid reservoir, and the base and body are rotatable with respect to one another to define a first configuration and a second configuration of the wetting mechanism. In the second configuration, the wetting mechanism permits release of fluid from the fluid reservoir into the sleeve to wet the catheter. Preferably, in the first configuration the wetting mechanism inhibits release of fluid from the fluid reservoir into the sleeve. Preferably, the catheter is an intermittent male urinary catheter. Preferably, the body is longer than the base.

Abstract: Disclosed is a housing for a catheter, the housing comprising: a body; a cap assembly comprising a cap and a tamper-evidence ring, wherein the cap is attached to the body and the tamper-evidence ring in an unopened configuration and is configured to be irreversibly detached from the tamper-evidence ring when the cap is removed from the body, the housing further comprising at least one anti-rotation mechanism to prevent rotation of the tamper-evidence ring upon rotation of the cap, and at least one axial retention mechanism configured to axially retain the tamper-evidence ring when irreversibly detached from the cap.

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

Abstract: An intermittent catheter, preferably a female intermittent catheter, is provided in an assembly. The assembly may include a cap which may be attachable to the base of the assembly in use, and/or a seal which misaligns with sealing surfaces of a chamber wall and a moveable insert in use. It may have a two-step deployment, and/or a sheath that pulls out a storage chamber. Internal and external housing may define the storage chamber. The housing may have a filling aperture and/or the storage chamber may comprise an insert configured to move axially in response to rotation.

Abstract: An intermittent catheter, preferably a female intermittent catheter, is provided in an assembly. The assembly may include a cap which may be attachable to the base of the assembly in use, and/or a seal which misaligns with sealing surfaces of a chamber wall and a moveable insert in use. It may have a two-step deployment, and/or a sheath that pulls out a storage chamber. Internal and external housing may define the storage chamber. The housing may have a filling aperture and/or the storage chamber may comprise an insert configured to move axially in response to rotation.

Abstract: The invention is directed to a food package that includes a writing section that is dedicated to receiving a written message. Specifically, the package writing section allows a user to easily customize a message to a recipient by writing or drawing directly within the section. In this way, the user ensures that the message is seen by the recipient when accessing the package.

Abstract: Described is a catheter arrangement in which a sealed container of wetting agent is provided in a housing cap. The sealed container is pierced with a piercing member such that the wetting agent is directed towards the catheter. The wetting agent may bypass a handling surface of the catheter whilst being directed to the catheter tube.

Abstract: An intermittent catheter, preferably a female intermittent catheter, is provided in an assembly. The assembly may include a cap which may be attachable to the base of the assembly in use, and/or a seal which misaligns with sealing surfaces of a chamber wall and a moveable insert in use. It may have a two-step deployment, and/or a sheath that pulls out a storage chamber. Internal and external housing may define the storage chamber. The housing may have a filling aperture and/or the storage chamber may comprise an insert configured to move axially in response to rotation.

Abstract: Disclosed is a housing for a catheter, the housing comprising: a body; a cap assembly comprising a cap and a tamper-evidence ring, wherein the cap is attached to the body and the tamper-evidence ring in an unopened configuration and is configured to be irreversibly detached from the tamper-evidence ring when the cap is removed from the body, the housing further comprising at least one anti-rotation mechanism to prevent rotation of the tamper-evidence ring upon rotation of the cap, and at least one axial retention mechanism configured to axially retain the tamper-evidence ring when irreversibly detached from the cap.

Abstract: An intermittent catheter, preferably a female intermittent catheter, is provided in an assembly. The assembly may include a cap which may be attachable to the base of the assembly in use, and/or a seal which misaligns with sealing surfaces of a chamber wall and a moveable insert in use. It may have a two-step deployment, and/or a sheath that pulls out a storage chamber. Internal and external housing may define the storage chamber. The housing may have a filling aperture and/or the storage chamber may comprise an insert configured to move axially in response to rotation.

Abstract: An intermittent catheter, preferably a female intermittent catheter, is provided in an assembly. The assembly may include a cap which may be attachable to the base of the assembly in use, and/or a seal which misaligns with sealing surfaces of a chamber wall and a moveable insert in use. It may have a two-step deployment, and/or a sheath that pulls out a storage chamber. Internal and external housing may define the storage chamber. The housing may have a filling aperture and/or the storage chamber may comprise an insert configured to move axially in response to rotation.

Abstract: An intermittent catheter, preferably a female intermittent catheter, is provided in an assembly. The assembly may include a cap which may be attachable to the base of the assembly in use, and/or a seal which misaligns with sealing surfaces of a chamber wall and a moveable insert in use. It may have a two-step deployment, and/or a sheath that pulls out a storage chamber. Internal and external housing may define the storage chamber. The housing may have a filling aperture and/or the storage chamber may comprise an insert configured to move axially in response to rotation.

Abstract: Described is a catheter arrangement in which a sealed container of wetting agent is provided in a housing cap. The sealed container is pierced with a piercing member such that the wetting agent is directed towards the catheter. The wetting agent may bypass a handling surface of the catheter whilst being directed to the catheter tube.

Abstract: The invention relates to water soluble 18F-prosthetic groups and the synthesis and use of 18F-labeled biological molecules containing the 18F-prosthetic groups for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

Abstract: The invention relates to water soluble 18F-prosthetic groups and the synthesis and use of 18F-labeled biological molecules containing the 18F-prosthetic groups for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

Abstract: The invention relates to water soluble 18F-prosthetic groups and the synthesis and use of 18F-labeled biological molecules containing the 18F-prosthetic groups for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

Abstract: A hidden siding fastener is provided. The hidden siding fastener includes an upper nail hem hook and an opposing lower pressure point, fold point and lock engagement hook extending therefrom. The nail hem hook is threaded through the back side of a lower piece of siding panel so that the lock engagement hook can nest into a siding lock slot of the same siding panel. Thereby, a separate upper piece of siding panel and specifically its siding lock hook can operatively associate with the lock engagement hook and fold point in a locked engagement, while the pressure point urges a more secure locked engagement between the two pieces of siding panel.