Abstract: Provided are compositions and methods that include one or more of: (1) a Class 2 CRISPR/Cas effector protein, a nucleic acid encoding the effector protein, and/or a modified host cell comprising the effector protein (and/or a nucleic acid encoding the same); (2) a CRISPR/Cas guide RNA that binds to and provides sequence specificity to the Class 2 CRISPR/Cas effector protein, a nucleic acid encoding the CRISPR/Cas guide RNA, and/or a modified host cell comprising the CRISPR/Cas guide RNA (and/or a nucleic acid encoding the same); and (3) a CRISPR/Cas transactivating noncoding RNA (trancRNA), a nucleic acid encoding the CRISPR/Cas trancRNA, and/or a modified host cell comprising the CRISPR/Cas trancRNA (and/or a nucleic acid encoding the same).

Abstract: An implantable system includes an implantable medical device (IMD) and a non-transvenous lead that is configured to be implanted outside of a heart. The IMD includes an output configured to be connected at least to the lead, a current generator (CG) circuit configured to generate pacing pulses, a switching circuit coupled between the CG circuit and the output, one or more capacitors coupled in parallel with the CG circuit and the switching circuit, and a control circuit coupled to the CG circuit. The control circuit is configured to manage the CG circuit to generate the pacing pulses with a constant current at the output.

Abstract: Described herein are methods, devices and systems for efficiently storing data for sensed biological signals. A sensed biological signal, or an amplitude and/or filtered version thereof, is provided to an N-bit ADC of an IMD to produce an N-bit data value indicative of an amplitude of the biological signal at a point in time. One of a plurality of chords of a compression curve is selected, based on a magnitude of the N-bit data value, and used to produce an M-bit data value, which is a compressed version of the N-bit data value, wherein M<N. The M-bit data value is stored as an M-bit data slice within memory of the IMD, and can be expanded to a reproduced N-bit data value after being uploaded to a non-implanted device or system.

Abstract: An implantable system includes an implantable medical device (IMD) and a non-transvenous lead that is configured to be implanted outside of a heart. The IMD includes an output configured to be connected at least to the lead, a current generator (CG) circuit configured to generate pacing pulses, a switching circuit coupled between the CG circuit and the output, one or more capacitors coupled in parallel with the CG circuit and the switching circuit, and a control circuit coupled to the CG circuit. The control circuit is configured to manage the CG circuit to generate the pacing pulses with a constant current at the output.

Abstract: Circuits, devices and methods are provided to manage modifications to protected registers within an implantable medical device (IMD). The circuit comprises a bus controller that includes an address register, an unlock register and a protected register (PR) enable unit. The PR enable unit sets a protect enable signal to an access state based on content loaded into the unlock register. A peripheral block includes a protected register that retains content for operating the IMD. The peripheral block includes a register access input to receive the protected enable signal. A PR write control unit is provided to enable an attempted write of the content from a data interface to the protected register when the protected enable signal has an access state.

Abstract: Circuits, devices and methods are provided to manage modifications to protected registers within an implantable medical device (IMD). The circuit comprises a bus controller that includes an address register, an unlock register and a protected register (PR) enable unit. The PR enable unit sets a protect enable signal to an access state based on content loaded into the unlock register. A peripheral block includes a protected register that retains content for operating the IMD. The peripheral block includes a register access input to receive the protected enable signal. A PR write control unit is provided to enable an attempted write of the content from a data interface to the protected register when the protected enable signal has an access state.

Abstract: An implantable medical device (IMD) may include a communication module, a therapy control module, a firmware control module, and a service application. The communication module is configured to wirelessly communicate over an RF link with an external device. The therapy control module is configured to deliver therapy to the patient, and may include a reprogrammable therapy logic circuit configured to operate the therapy control module in a reprogrammable mode of operation, and base-therapy state machine (BTSM) logic circuit configured to operate the therapy control module in a base therapy mode of operation. The firmware control module may include CPU and a memory. The service application may be stored in the memory. The firmware control module is configured to launch the service application, and the BTSM logic circuit provides a base level of sensing and pacing therapy while the communications module in parallel maintains the RF link with the external device.

Abstract: An implantable medical device (IMD) may include a communication module, a therapy control module, a firmware control module, and a service application. The communication module is configured to wirelessly communicate over an RF link with an external device. The therapy control module is configured to deliver therapy to the patient, and may include a reprogrammable therapy logic circuit configured to operate the therapy control module in a reprogrammable mode of operation, and base-therapy state machine (BTSM) logic circuit configured to operate the therapy control module in a base therapy mode of operation. The firmware control module may include CPU and a memory. The service application may be stored in the memory. The firmware control module is configured to launch the service application, and the BTSM logic circuit provides a base level of sensing and pacing therapy while the communications module in parallel maintains the RF link with the external device.