Abstract: A blow-molded container including a finish and a base. The finish defines an opening at a first end of the container that provides access to an internal volume. The base includes a diaphragm and a standing surface. The diaphragm extends radially outward from a central push-up portion. The standing surface of the container is at a second end of the container. In response to an internal vacuum caused by hot-filling and closing the container, the diaphragm is configured to move passively from an as-blown first configuration to a second configuration in which the diaphragm is closer to the first end of the container as compared to the as-blown first configuration. The diaphragm is configured to move from the second configuration to an activated third configuration in which the diaphragm is closer to the first end of the container in response to the diaphragm being externally actuated by a tool.

Abstract: A child resistant closure for use on a container that include an inner closure member having a threaded portion and an inclined surface, and an outer closure member coupled to the inner closure member for axial translation therebetween. A series of engagement features extend between the inner and outer closure to permit selective engagement of the outer closure to the inner closure to effect removal of the child resistant closure. The outer closure includes at least one finger spring member being inwardly directed and contacting the inclined surface of the inner closure member, thereby biasing the outer closure member into an operationally disengaged position. The finger spring member T-shaped in cross-section.

Abstract: A method for acquiring a remote object is provided. The method comprises obtaining a sequence of position samples of the remote object, identifying one or more sets of spatially clustered position samples from among the obtained position samples, and applying curve-fitting to at least one set of spatially clustered position samples to obtain a trajectory of the set of spatially clustered position samples. Also provided is a method for tracking a remote object. The method comprising obtaining an estimated trajectory of the object, obtaining one or more position samples of the object, comparing the obtained position samples with positions computed based on the estimated trajectory, and determining that the object is being tracked based on whether the obtained position samples are consistent with the computed positions.

Abstract: Friction reducers for hydraulic fracturing fluids, hydraulic fracturing fluids containing the friction reducers, and methods of making and using same are disclosed. The friction reducers comprise ethylene oxide polymers, propylene oxide polymers, ethylene oxide-propylene oxide co-polymers, and combinations thereof, and can further comprise a dispersant, such as polypropylene glycol. The friction reducer formulations can be active across a wide range of brine salinities, and tolerant of high levels of divalent cations in solution. The friction reducers can have a cloud point temperature, above which temperature they can precipitate out of solution and deposit on a surface of a hydrocarbon-bearing formation to inhibit hydration of the shale formations lining the fractures.

Abstract: A system for deploying a first object for capturing, immobilising or disabling a second object is provided. The system comprises the first object, a projectile for carrying the first object therein,and a launcher for launching the projectile towards the second object,wherein the projectile is configured for deploying the first object in the vicinity of the second object for capturing, immobilising or disabling the second object.

Abstract: A plastic container including an upper portion, a base, a plurality of surface features, and a substantially cylindrical portion. The upper portion has a mouth defining an opening into the container. The base is movable to accommodate vacuum forces generated within the container thereby decreasing the volume of the container. The plurality of surface features are included with the base and are configured to accommodate vacuum forces. The substantially cylindrical portion extends between the upper portion and the base.

Abstract: Friction reducers for hydraulic fracturing fluids, hydraulic fracturing fluids containing the friction reducers, and methods of making and using same are disclosed. The friction reducers comprise ethylene oxide polymers, propylene oxide polymers, ethylene oxide-propylene oxide co-polymers, and combinations thereof, and can further comprise a dispersant, such as polypropylene glycol. The friction reducer formulations can be active across a wide range of brine salinities, and tolerant of high levels of divalent cations in solution. The friction reducers can have a cloud point temperature, above which temperature they can precipitate out of solution and deposit on a surface of a hydrocarbon-bearing formation to inhibit hydration of the shale formations lining the fractures.

Abstract: Processes for preparing extracts of natural products such as plant material, and for preparing purified extracts from crude extracts of natural products, by extraction with hot gas. Apparatus suitable for use in preparing extracts of natural products are also described.

Abstract: A plastic container has a base adapted for vacuum pressure absorption. The base portion includes a chime extending from a body portion to a contact ring which defines a surface upon which the container is supported. The base further includes a central portion defined in at least part by a pushup having a generally truncated cone shape in cross section located on a longitudinal axis of the container, and an inversion ring having a generally S shaped geometry in cross section and hinge means formed therein, and circumscribing the pushup. The truncated cone has an overall general diameter that is at most 30% of an overall general diameter of the base and a top surface generally parallel to a support surface.

Abstract: The present invention provides novel methods for enhancing the delivery of transduced cells to a subject, which include both methods of selecting for transduced cells and methods of enhancing the reconstitution by transduced cells in a transplant recipient. The present invention further provides transfer vectors, including lentiviral vectors, useful in practicing the methods of the present invention. The methods and vectors of the present invention may be used in gene therapy of a variety of diseases and disorders, including but not limited to hematological diseases and disorders.

Abstract: The invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

Abstract: A plastic container including an upper portion, a base, a plurality of surface features, and a substantially cylindrical portion. The upper portion has a mouth defining an opening into the container. The base is movable to accommodate vacuum forces generated within the container thereby decreasing the volume of the container. The plurality of surface features are included with the base and are configured to accommodate vacuum forces. The substantially cylindrical portion extends between the upper portion and the base.

Abstract: The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

Abstract: A container body and base being lightweight structures designed to accommodate vacuum forces either simultaneously or in sequence. The container body and base each absorb a significant percentage of the vacuum. By utilizing a lightweight base design to absorb a portion of the vacuum forces enables an overall light-weighting, design flexibility, and effective utilization of alternative vacuum absorbing capabilities on the container body.

Abstract: A container having a finish, a sidewall portion extending from the finish, a base portion extending from the sidewall portion and enclosing the sidewall portion to form a volume therein for retaining a commodity, and a panel area disposed in the sidewall portion. The panel area includes a belt land portion and a pair of inset portions in mirrored arrangement relative to the belt land portion, and a generally oval boundary area surrounding and containing the belt land portion and inset portions.

Abstract: The invention is directed to certain novel compounds directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

Abstract: The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.

Abstract: A plastic container has a base adapted for vacuum pressure absorption. The base portion includes a chime extending from a body portion to a contact ring which defines a surface upon which the container is supported. The base further includes a central portion defined in at least part by a pushup having a generally truncated cone shape in cross section located on a longitudinal axis of the container, and an inversion ring having a generally S shaped geometry in cross section and hinge means formed therein, and circumscribing the pushup. The truncated cone has an overall general diameter that is at most 30% of an overall general diameter of the base and a top surface generally parallel to a support surface.

Abstract: A plastic container has a base adapted for vacuum pressure absorption. The base portion includes a chime extending from a body portion to a contact ring which defines a surface upon which the container is supported. The base further includes a central portion defined in at least part by a pushup having a generally truncated cone shape in cross section located on a longitudinal axis of the container, and an inversion ring having a generally S shaped geometry in cross section and hinge means formed therein, and circumscribing the pushup. The truncated cone has an overall general diameter that is at most 30% of an overall general diameter of the base and a top surface generally parallel to a support surface.