Patents by Inventor David Driver

David Driver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to tau and methods of treatment therewith
    Patent number: 10011653
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: July 3, 2018
    Assignee: Eli Lilly and Company
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
  • ANTIBODIES TO TAU AND USES THEREOF
    Publication number: 20170107278
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Application
    Filed: November 10, 2016
    Publication date: April 20, 2017
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
  • Antibodies to tau and uses thereof
    Patent number: 9527909
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: December 27, 2016
    Assignee: Eli Lilly and Company
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
  • ANTIBODIES TO TAU AND USES THEREOF
    Publication number: 20160251420
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Application
    Filed: February 18, 2016
    Publication date: September 1, 2016
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
  • NON-EQUILIBRIUM TWO-SITE ASSAYS FOR LINEAR, ULTRASENSITIVE ANALYTE DETECTION
    Publication number: 20150044666
    Abstract: Methods and kits related to non-equilibrium, ultrasensitive two-site assays for detecting analytes are provided. In one aspect, a two-site assays for detecting analytes under non-equilibrium analyte binding conditions, using low concentrations of reporter specificity molecule (e.g., reporter antibody) and kits for performing the same is provided. In another aspect, methods for selecting antibodies or specificity molecules with low dissociation constants for use as reporter antibodies in non-equilibrium two-site immunoassays, including two-site immuno-PCR assays, and assays performed with those antibodies, are also provided.
    Type: Application
    Filed: January 11, 2013
    Publication date: February 12, 2015
    Inventors: Edward Jablonski, Thomas H. Adams, David Driver, Thomas Brendan Ryder
  • Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
    Patent number: 8647864
    Abstract: Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: February 11, 2014
    Assignee: Novartis AG
    Inventors: John M Polo, Thomas W Dubensky, Jr., Ilya Frolov, Jason P Gardner, Gillis Otten, Susan Barnett, David A Driver
  • Eukaryotic layered vector initiation systems
    Patent number: 7977091
    Abstract: The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: July 12, 2011
    Assignee: Novartis Vaccines & Diagnostics, Inc.
    Inventors: Thomas W. Dubensky, Jr., John M Polo, Carlos E Ibanez, Stephen M. W. Chang, Douglas J Jolly, David A Driver, Barbara A Belli
  • Compositions and Methods for Generating an Immune Response Utilizing Alphavirus-Based Vector Systems
    Publication number: 20100266631
    Abstract: Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses.
    Type: Application
    Filed: June 29, 2010
    Publication date: October 21, 2010
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.
    Inventors: John Polo, Thomas W. Dubensky, JR., Ilya Frolov, Jason P. Gardner, Gillis Otten, Susan Barnett, David A. Driver
  • Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
    Patent number: 7771979
    Abstract: Methods are provided for generating immune responses utilizing alphavirus-based vector systems.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: August 10, 2010
    Assignee: Novartis Vaccines & Diagnostics, Inc.
    Inventors: John Polo, Thomas W. Dubensky, Jr., Ilya Frolov, Jason P. Gardner, Gillis Otten, Susan Barnett, David A. Driver
  • Eukaryotic Layered Vector Initiation Systems
    Publication number: 20100173412
    Abstract: The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors.
    Type: Application
    Filed: August 10, 2009
    Publication date: July 8, 2010
    Inventors: Thomas W. Dubensky, JR., John M. Polo, Carlos E. Ibanez, Stephen M.W. Chang, Douglas J. Jolly, David A. Driver, Barbara A. Belli
  • Eukaryotic layered vector initiation systems
    Patent number: 7572628
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: August 11, 2009
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Carlos E. Ibanez, Stephen M. W. Chang, Douglas J. Jolly, David A. Driver, Barbara A. Belli
  • Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
    Publication number: 20080226598
    Abstract: Methods are provided for generating immune responses utilizing alphavirus-based vector systems.
    Type: Application
    Filed: February 27, 2007
    Publication date: September 18, 2008
    Inventors: John Polo, Thomas W. Dubensky, Ilya Frolov, Jason P. Gardner, Gillis Otten, Susan Barnett, David A. Driver
  • Monitoring message queues and starting processing applications
    Publication number: 20070118841
    Abstract: Allowing queue messages to be pulled by one or more applications. A method may be practiced, for example, in a computing environment including applications configured to receive messages from queues. The method includes correlating applications to queues by correlating queue names to application locations. A queue is monitored to discover new messages in the queue. The method further includes receiving a notification that a new message has been added to the queue. An indication is provided to an activation service to allow the activation service to activate an application correlated to the queue and to allow the application to pull the new message from the queue.
    Type: Application
    Filed: November 22, 2005
    Publication date: May 24, 2007
    Inventors: David Driver, Geoffrey Kizer, Krishnan Srinivasan, Uday Hedge
  • Reliably transferring queued application messages
    Publication number: 20060168023
    Abstract: The present invention extends to methods, systems, and computer program products for reliably and securely transferring queued application messages. Application messages are (e.g.,. binary or text) encoded and then encapsulated in transfer messages, enqueue messages, and dequeue responses such that composable protocol elements used in application messages can be reused in the transfer messages, enqueue messages, and dequeue responses. Transfer message headers are encoded and then encapsulated along with encoded application messages such that composable protocol elements used in transfer headers and application messages can be reused in the store and forward messages. Application messages, transfer messages, enqueue messages, dequeue responses, and store and forward messages can all be configured in accordance with the same messaging protocol, such as, for example, Simple Object Access Protocol.
    Type: Application
    Filed: December 10, 2004
    Publication date: July 27, 2006
    Applicant: Microsoft Corporation
    Inventors: Krishnan Srinivasan, Craig Critchley, Uday Hegde, Alan Geller, David Driver, Richard Hill, Rodney Limprecht
  • Reliably transferring queued application messages
    Publication number: 20060168052
    Abstract: The present invention extends to methods, systems, and computer program products for reliably and securely transferring queued application messages. Application messages are (e.g., binary or text) encoded and then encapsulated in transfer messages, enqueue messages, and dequeue responses such that composable protocol elements used in application messages can be reused in the transfer messages, enqueue messages, and dequeue responses. Transfer message headers are encoded and then encapsulated along with encoded application messages such that composable protocol elements used in transfer headers and application messages can be reused in the store and forward messages. Application messages, transfer messages, enqueue messages, dequeue responses, and store and forward messages can all be configured in accordance with the same messaging protocol, such as, for example, Simple Object Access Protocol.
    Type: Application
    Filed: June 23, 2005
    Publication date: July 27, 2006
    Applicant: Microsoft Corporation
    Inventors: Krishnan Srinivasan, Craig Critchley, Uday Hegde, Alan Geller, David Driver, Richard Hill, Rodney Limprecht
  • Interface infrastructure for creating and interacting with web services
    Publication number: 20060150200
    Abstract: A web services namespace pertains to an infrastructure for enabling creation of a wide variety of applications. The infrastructure provides a foundation for building message-based applications of various scale and complexity. The infrastructure or framework provides APIs for basic messaging, secure messaging, reliable messaging and transacted messaging. In some embodiments, the associated APIs are factored into a hierarchy of namespaces in a manner that balances utility, usability, extensibility and versionability.
    Type: Application
    Filed: December 3, 2004
    Publication date: July 6, 2006
    Applicant: Microsoft Corporation
    Inventors: Shy Cohen, Geary Eppley, Douglas Purdy, James Johnson, Stephen Millet, Stephen Swartz, Vijay Gajjala, Aaron Stern, Alexander DeJarnatt, Alfred Lee, Anand Rjagopalan, Anastasios Kasiolas, Chaitanya Upadhyay, Christopher Kaler, Craig Critchley, David Levin, David Driver, David Wortendyke, Douglas Walter, Elliot Waingold, Erik Christensen, Erin Honeycutt, Eugene Shvets, Evgeny Osovetsky, Giovanni Della-Libera, Jesus Ruiz-Scougall, John Doty, Jonathan Wheeler, Kapil Gupta, Kenneth Wolf, Krishnan Srinivasan, Lance Olson, Matthew Tavis, Mauro Ottaviani, Max Feingold, Michael Coulson, Michael Marucheck, Michael Vernal, Michael Dice, Mohamed-Hany Ramadan, Mohammad Makarechian, Natasha Jethanandani, Richard Dievendorff, Richard Hill, Ryan Sturgell, Saurab Nog, Scott Seely, Serge Sverdlov, Siddhartha Puri, Sowmyanarayanan Srinivasan, Stefan Batres, Stefan Pharies, Tirunelveli Vishwanath, Tomasz Janczuk, Uday Hegde, Umesh Madan, Vaithialingam Balayogan, Vipul Modi, Yaniv Pessach, Yasser Shohoud
  • Reliably transferring queued application messages
    Publication number: 20060130069
    Abstract: The present invention extends to methods, systems, and computer program products for reliably and securely transferring queued application messages. Application messages are (e.g.,. binary or text) encoded and then encapsulated in transfer messages, enqueue messages, and dequeue responses such that composable protocol elements used in application messages can be reused in the transfer messages, enqueue messages, and dequeue responses. Transfer message headers are encoded and then encapsulated along with encoded application messages such that composable protocol elements used in transfer headers and application messages can be reused in the store and forward messages. Application messages, transfer messages, enqueue messages, dequeue responses, and store and forward messages can all be configured in accordance with the same messaging protocol, such as, for example, Simple Object Access Protocol.
    Type: Application
    Filed: June 23, 2005
    Publication date: June 15, 2006
    Applicant: Microsoft Corporation
    Inventors: Krishnan Srinivasan, Craig Critchley, Uday Hegde, Alan Geller, David Driver, Richard Hill, Rodney Limprecht
  • Application program interface for network software platform
    Publication number: 20050246716
    Abstract: An application program interface (API) provides a set of functions, including a set of base classes and types that are used in substantially all applications accessing the API, for application developers who build Web applications on Microsoft Corporation's .NET™ platform.
    Type: Application
    Filed: June 23, 2005
    Publication date: November 3, 2005
    Applicant: Microsoft Corporation
    Inventors: Adam Smith, Anthony Moore, Brian LaMacchia, Anders Hejlsberg, Brian Grunkemeyer, Caleb Doise, Christopher Brumme, Christopher Anderson, Corina Feuerstein, Craig Sinclair, Daniel Takacs, David Ebbo, David Driver, David Mortenson, Erik Christensen, Erik Olson, Fabio Yeon, Gopala Kakivaya, Gregory Fee, Hany Ramadan, Henry Sanders, Jayanth Rajan, Jeffrey Cooperstein, Jonathan Hawkins, James Hogg, Joe Long, John McConnell, Jesus Ruiz-Scougall, James Miller, Julie Bennett, Krzysztof Cwalina, Lance Olson, Loren Kohnfelder, Michael Magruder, Manish Prabhu, Radu Palanca, Raja Krishnaswamy, Shawn Burke, Sean Trowbridge, Seth Demsey, Shajan Dasan, Stefan Pharies, Suzanne Cook, Tarun Anand, Travis Muhlestein, Yann Christensen, Yung-shin Lin, Ramasamy Krishnaswamy, Joseph Roxe, Alan Boshier, David Bau
  • Application program interface for network software platform
    Publication number: 20050240943
    Abstract: An application program interface (API) provides a set of functions, including a set of base classes and types that are used in substantially all applications accessing the API, for application developers who build Web applications on Microsoft Corporation's .NET™ platform.
    Type: Application
    Filed: June 23, 2005
    Publication date: October 27, 2005
    Applicant: Microsoft Corporation
    Inventors: Adam Smith, Anthony Moore, Brian LaMacchia, Anders Hejlsberg, Biran Grunkemeyer, Caleb Doise, Christopher Brumme, Christopher Anderson, Corina Feuerstein, Craig Sinclair, Daniel Takacs, David Ebbo, David Driver, David Mortenson, Erik Christensen, Erik Olson, Fabio Yeon, Gopala Kakivaya, George Fee, Hany Ramadan, Henry Sanders, Jayanth Rajan, Jeffrey Cooperstein, Jonathan Hawkins, James Hogg, Joe Long, John McConnell, Jesus Ruiz-Scougall, James Miller, Julie Bennett, Krzysztof Cwalina, Lance Olson, Loren Kohnfelder, Michael Magruder, Manish Prabhu, Radu Palanca, Raja Krishnaswamy, Shawn Burke, Sean Trowbridge, Seth Demsey, Shajan Dasan, Stefan Pharies, Suzanne Cook, Tarun Anand, Travis Muhlestein, Yann Christensen, Yung-shin Lin, Ramasamy Krishnaswamy, Joseph Roxe, Alan Boshier, David Bau
  • Displacement sandwich immuno-PCR
    Publication number: 20050026161
    Abstract: The present invention is directed to labeling antibodies with DNA in a convenient kit format for the purpose of producing and utilizing nucleic acid detection immunoassays. The process comprises treating a reporter antibody with a chemically activated strand of DNA, which serves as a template for any DNA amplification system. The reporter antibody-DNA conjugate is used to form a complex with corresponding antigen. The complex can be detected by the production of multiple copies of the DNA template. The kit may also provide an activated DNA sequence to label a capture antibody. The DNA conjugated to the capture antibody is modified to contain a high affinity binding ligand for the purpose of coating a solid support. The coated solid support functions to capture the immune complex containing reporter antibody in a sandwich assay format. The DNA sequence of the capture antibody may also have properties providing for the detachment of the complex from the solid support.
    Type: Application
    Filed: November 3, 2003
    Publication date: February 3, 2005
    Inventors: Edward Jablonski, David Driver, Thomas Adams