Abstract: Balloon catheters for delivery of prosthetic hear valves are provided. The balloon catheters are configured to deploy a prosthetic heart valve through inflation. The balloon catheters are further configured with one or more retention bumpers to reduce or prevent migration of the prosthetic heart valve during delivery. Balloon catheters described herein are configured with substantially incompressible retention bumpers that promote longitudinal inflation fluid flow.

Abstract: Balloon catheters for delivery of prosthetic hear valves are provided. The balloon catheters are configured to deploy a prosthetic heart valve through inflation. The balloon catheters are further configured with one or more retention bumpers to reduce or prevent migration of the prosthetic heart valve during delivery. Balloon catheters described herein are configured with substantially incompressible retention bumpers that promote longitudinal inflation fluid flow.

Abstract: An information processing system, the information processing apparatus comprising circuitry configured to: control a display device to display a first image to a user; detect a gaze location of the user corresponding to a portion of the first image observed by the user; acquire one or more content properties of the first image displayed to the user based on an analysis of the first image; acquire user response data relating to the user's autonomic response to the display of the first image; and determine a state of the user's mental condition based on the user response data, the one or more content properties of the first image and the gaze location of the user, wherein the mental condition includes at least one of anxiety and/or depression.

Abstract: A system for determining an indicator value of cognitive impairment in a user comprising circuitry configured to: receive motion data from a wearable device worn by the user during a time period comprised of a first time period and a second time period, the second time period being after the first time period; compare the motion data received during the second time period with stored reference motion data, the stored reference motion data representing reference motion carried out when performing a predetermined task during the second period of time; determine the predetermined task based upon the comparison; compare the motion data received during the first time period with further stored reference motion data, the further stored reference motion data representing reference motion carried out when performing the determined predetermined task during the first time period; and determine the indicator value of the cognitive impairment based upon a comparison between the motion data received during the first time

Abstract: An information processing apparatus is provided for measuring a level of cognitive function in a user. the information processing apparatus comprising circuitry configured to: acquire a function specific to a user, the function characterizing the user's perception of sound: generate an audio sound based on the function specific to the user, wherein the audio sound is generated. for the user, to originate from a source location within a three-dimensional environment: determine a second location within the three-dimensional environment from where the user considers the audio sound to have originated based on a response of the user to the generation of the audio sound: and measure the level of cognitive function in the user in accordance with a difference between the source location and the second location.

Abstract: A package for a medical device such as an intermittent catheter has a case and a cap connected by threads. The case includes a hollow tube which is closed at one end and open at the other. A shoulder is formed near one end of the case. Above the shoulder is a cylindrical ferrule that includes external threads. The cap has internal threads selectably engageable with the threads on the ferrule to form a liquid-tight seal between the cap and case when the cap is installed on the case.

Abstract: A computer-implemented method for measuring cognitive load of a user creating a creative work in a creative work system, may include generating at least one verbal statement capable of provoking at least one verbal response from the user, prompting the user to vocally interact with the creative work system by vocalizing the at least one generated verbal statement to the user via an audio interface of the creative work system, and obtaining the at least one verbal response from the user via the audio interface, and determining the cognitive load of the user based on the at least one verbal response obtained from the user, wherein generating the at least one verbal statement is based on at least one predicted verbal response suitable for determining the cognitive load of the user.

Abstract: An apparatus comprising means for: obtaining a predicted breathing sequence of a user; obtaining a desired breathing phase for consuming a first media content; and causing rendering of the first media content to the user at a first time which is based, at least in part, on a predicted time in the predicted breathing sequence at which the desired breathing phase occurs.

Abstract: A computer-implemented method and an apparatus for generating an action-to-feature mapping of a visual artwork may include initializing a system to create a visual artwork in, and obtaining an input stream of data recording a creation of a visual artwork from the system, and identifying, based on the input stream of data, at least one time series of utensil actions capable of reproducing the visual artwork, and obtaining at least one image of the visual artwork, and generating the action-to-feature mapping based on the at least one time series of utensil actions and on the at least one image of the visual artwork, thereby recognizing at least one artistic feature of the visual artwork. The action-to-feature mapping may include at least one pair of at least one utensil action of the at least one time series of utensil actions and the at least one artistic feature.

Abstract: Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Pol?) activity, in particular inhibit Pol? activity by inhibiting ATP dependent helicase domain activity of Pol?. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Pol? such as cancer, including homologous recombination (HR) deficient cancers.

Abstract: A computer-implemented method and an apparatus for generating and running a creative tutorial algorithm for creating a visual artwork may include obtaining data defining a creative objective and identifying the creative objective based on the data defining the creative objective, and obtaining information about at least one targeted artistic style and identifying the at least one targeted artistic style based on the information about the at least one targeted artistic style, and accessing a plurality of predetermined artistic styles and identifying, based on the plurality of predetermined artistic styles, at least one predetermined artistic style matching the at least one targeted artistic style, thereby specifying at least one targeted predetermined artistic style, and generating the creative tutorial algorithm. The creative tutorial algorithm is configured to include instructions on how to reproduce the creative objective in terms of the at least one targeted predetermined artistic style.

Abstract: The present disclosure relates to a computer-implemented method for handwriting-to-text-summarization, comprising obtaining, via a user interface of a system, a handwriting input representing a handwriting of a user of the system for handwriting-to-text-summarization, recognizing a text in the handwriting input, extracting at least one dynamic feature of the handwriting from the handwriting input, generating a text summary of the text, wherein generating the text summary is based on the text and on the at least one dynamic feature of the handwriting. The present disclosure also relates to a system for handwriting-to-text-summarization, comprising a user interface comprising a capturing subsystem configured to capture a handwriting of a user of the system, and wherein the system is configured to run the method for handwriting-to-text-summarization.

Abstract: A prolapse prevention device formed by a continuous wire-like structure having a first end and a second end disconnected from each other. The continuous wire-like structure is substantially straight in a delivery configuration. The prolapse prevention device in a deployed configuration includes a centering ring of the continuous wire-like structure configured to seat adjacent to and upstream of an annulus of a heart valve in situ, a vertical support of the continuous wire-like structure which extends from the centering ring and includes an apex configured to seat against a roof of an atrium in situ, and a leaflet backstop of the continuous wire-like structure extending radially inward from the centering ring and configured to contact at least at least a first leaflet of the heart valve in situ to exert a pressure in a downstream direction on the first leaflet to prevent the first leaflet from prolapsing into the atrium.

Abstract: A writing instrument configured to apply a writing material or liquid to a surface, comprising a socket, and a ball arranged in the socket, characterized by at least one first component which is arranged to come into contact with the ball, wherein the at least one first component comprises a first material having surface properties such that the friction coefficient between the ball and the at least one first component decreases when the force acting from the ball on the at least one first component increases at least within a certain range of forces.

Abstract: A writing instrument may include a self-healing sealing component to prevent the internal components of the writing instrument from drying out.

Abstract: An apparatus comprising means for, a method comprising, and a computer program that performs: preventing rendering, via the apparatus, of a message received at the apparatus; determining an association between the received message and an external, real object; and enabling rendering of the message via the apparatus in response to a change from a first physical relationship between a user and the external, real object to a second physical relationship between the user and the external, real object.

Abstract: A computer-implemented method for designing a user-specific electronic tattoo that comprises obtaining a user-input is provided. The user-input includes one or more desired functions of the electronic tattoo and a desired appearance of the electronic tattoo. The method further comprises generating a design of the electronic tattoo based on the user-input. The generation of the design of the electronic tattoo includes determining an electronic circuit design which is capable of achieving the one or more desired functions. The generation further includes designing a final image of the electronic tattoo that mimics the desired appearance and incorporates the electronic circuit design.

Abstract: An apparatus comprising means for: rendering first content to a first user, the first content being based on recorded content associated with a second user; eye tracking in a time interval following the rendering of the first content to obtain eye-tracking data of the first user; determining first data indicative of whether or not there is a match between the eye-tracking data of the first user and reference eye-tracking data associated with the recorded content associated with the second user; receiving second data indicative of whether or not there is a match between eye-tracking data of the second user and reference eye-tracking data associated with recorded content associated with the first user; and if both the first and second data are indicative of a match, then providing the first user with a telecommunication option configured to initiate communication with the second user.

Abstract: A writing instrument comprises a body, a first data handling subsystem arranged in the body and configured to transmit and/or receive data, and a haptic feedback subsystem arranged in the body and configured to receive data from the first data handling subsystem. The haptic feedback subsystem is configured to provide a haptic feedback to a user based on data received from the first data handling subsystem.

Abstract: According to various, but not necessarily all, embodiments there is provided an apparatus comprising means for binocularly displaying visual content as a first image directed towards a first eye of a user and as a second image directed towards a second eye of the user. The first image comprises a first area in which a blue spectral component of the visual content is reduced as compared to a corresponding first area of the second image. The second image comprises a second, different area in which a blue spectral component of the visual content is reduced as compared to a corresponding second area of the first image.