Patents by Inventor David E. Briles

David E. Briles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190351043
    Abstract: The present embodiments provide compositions and methods related to novel recombinant protein immunogens, comprising specific portions of alpha helical domains (aHD) and proline rich regions (PRD) of pneumococcal surface protein A (PspA), which portions are linked to provide aHD-PRD constructs. The aHD and PRD proteins constituting the aHD-PRD constructs are selected to maximize cross-reactivity and provide protection against a broad spectrum of pneumococcal serotypes. Immunogenic compositions, including vaccines, comprising at least one aHD PRD construct may also include a non-linked aHD portion. Also provided are recombinant nucleic acid molecules that encode aHD-PRD constructs, vectors and recombinant host cells containing such molecules, aHD-PRD expression products, use of such nucleic acid molecules to express aHD-PRD constructs by recombinant techniques, and use of the expression products to elicit an immune or protective response against pneumococcal disease in a suitable host.
    Type: Application
    Filed: December 1, 2017
    Publication date: November 21, 2019
    Applicants: The UAB Research Foundation, The University of Tokyo
    Inventors: David E. BRILES, Hiroshi KIYONO, Robert KNELLER, Reshmi MUKERJI, Kristopher GENSCHMER, Yoshikazu YUKI
  • Patent number: 9132179
    Abstract: Provided herein are compositions designed to reduce or prevent bacterial infections (for example pneuomococcal infections), nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a pneumococcal neuraminidase, phosphocholine, pneumococcal teichoic acid, pneumococcal lipoteichoic acid, or an antigenic portion of either neuraminidase, phosphocholine, pneumococcal teichoic acid, pneumococcal lipoteichoic acid. Optionally, the composition can comprise any combination of a pneumococcal neuraminidase, a phosphocholine, a pneumococcal teichoic acid, a pneumococcal lipoteichoic acid or an antigenic portion of any one of these. Optionally the agents are detoxified. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein.
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: September 15, 2015
    Assignee: The UAB Research Foundation
    Inventors: Frederik W. Van Ginkel, David E. Briles, James M. Watt
  • Patent number: 9080159
    Abstract: Provided herein are compositions designed to reduce or prevent bacterial infections (for example pneuomococcal infections), nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO:19 or a variant thereof that can elicit an anti-neuraminidase immune response. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: July 14, 2015
    Assignee: The UAB Research Foundation
    Inventors: David E. Briles, Susan K. Hollingshead
  • Patent number: 8808704
    Abstract: The embodiments described herein provide for immunogenic portions of Streptococcus pneumoniae surface protein A and surface protein C lacking alpha helical structure.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: August 19, 2014
    Assignee: The UAB Research Foundation
    Inventors: Susan K. Hollingshead, David E. Briles
  • Publication number: 20140004138
    Abstract: Provided herein are compositions designed to reduce or prevent bacterial infections (for example pneuomococcal infections), nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO:19 or a variant thereof that can elicit an anti-neuraminidase immune response. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.
    Type: Application
    Filed: November 7, 2012
    Publication date: January 2, 2014
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: David E. Briles, Susan K. Hollingshead
  • Patent number: 8329195
    Abstract: Provided herein are compositions designed to reduce or prevent pneuomococcal infections, nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 19 or a variant thereof that can elicit an anti-neuraminidase immune response. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: December 11, 2012
    Assignee: The UAB Research Foundation
    Inventors: David E. Briles, Susan K. Hollingshead
  • Patent number: 8252546
    Abstract: Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic polypeptides. Further provided is a method of diagnosing pneumococcal infection (e.g., pneumonia) in a subject by obtaining a biological sample from the subject and detecting one or more pneumococcal antigens that are selectively expressed during invasion (e.g., PcpA or fragments thereof).
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: August 28, 2012
    Assignee: The UAB Research Foundation
    Inventors: David E. Briles, Susan K. Hollingshead
  • Publication number: 20110104168
    Abstract: Provided herein are compositions designed to reduce or prevent pneuomococcal infections, nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 19 or a variant thereof that can elicit an anti-neuraminidase immune response. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.
    Type: Application
    Filed: May 23, 2007
    Publication date: May 5, 2011
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: David E. Briles, Susan K. Hollingshead
  • Publication number: 20110002962
    Abstract: Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PcpA and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
    Type: Application
    Filed: August 17, 2007
    Publication date: January 6, 2011
    Applicants: THE UAB RESEARCH FOUNDATION, SANOFI PASTEUR LTD.
    Inventors: David E. Briles, Susan K. Hollingshead, Jeremy Yethon, Joe Wang
  • Publication number: 20100227341
    Abstract: Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic polypeptides. Further provided is a method of diagnosing pneumococcal infection (e.g., pneumonia) in a subject by obtaining a biological sample from the subject and detecting one or more pneumococcal antigens that are selectively expressed during invasion (e.g., PcpA or fragments thereof).
    Type: Application
    Filed: August 17, 2007
    Publication date: September 9, 2010
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: David E. Briles, Susan K. Hollingshead
  • Publication number: 20090170162
    Abstract: The embodiments described herein provide for immunogenic portions of Streptococcus pneumoniae surface protein A and surface protein C lacking alpha helical structure.
    Type: Application
    Filed: February 1, 2007
    Publication date: July 2, 2009
    Applicant: THE UNIVERSITY OF ALABAMA RESEARCH FOUNDATION
    Inventors: Susan K. Hollingshead, David E. Briles
  • Patent number: 7189404
    Abstract: The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned sequences of a C-terminal region of an alpha helical region of PspA. Additionally, the families are further comprised of clades, wherein PspAs from strains which belong to a clade exhibit greater than 75% sequence homology in aligned sequences of the C-terminal region of the alpha helix of PspA. Vaccine compositions of the present invention preferably comprise a minimum of 4 and a maximum of 6 strains representing a single clade each, and the at least two PspAs are optionally serologically or broadly cross-reactive.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: March 13, 2007
    Assignee: The UAB Research Foundation
    Inventors: Robert S. Becker, David E. Briles, Susan Hollingshead
  • Patent number: 7078042
    Abstract: Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: July 18, 2006
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Susan K. Hollingshead, Alexis Brooks-Walter
  • Patent number: 7049419
    Abstract: Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: May 23, 2006
    Assignee: The UAB Research Foundation
    Inventors: David E. Briles, Susan K. Hollingshead, Alexis Brooks-Walter
  • Publication number: 20040077847
    Abstract: The present invention relates to pneumococcal genes, portions thereof, expression products therefrom and uses of such genes, portions and products; especially to genes of Streptococcus pneumoniae, e.g., the gene encoding pneumococcal surface protein A (PspA), i.e., the pspA gene, the gene encoding pneumococcal surface protein A-like proteins, such as pspA-like genes, e.g., the gene encoding pneumococcal surface protein C (PspC), i.e., the pspC gene, portions of such genes, expression products therefrom, and the uses of such genes, portions thereof and expression products therefrom.
    Type: Application
    Filed: November 19, 2002
    Publication date: April 22, 2004
    Inventors: David E. Briles, Larry S. McDaniel, Edwin Swiatlo, Janet Yother, Marilyn J. Crain, Susan Hollingshead, Rebecca Tart, Alexis Brooks-Walter
  • Publication number: 20040067237
    Abstract: The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned sequences of a C-terminal region of an alpha helical region of PspA. Additionally, the families are further comprised of clades, wherein PspAs from strains which belong to a clade exhibit at least 75% sequence homology in aligned sequences of the C-terminal region of the alpha helix of PspA. Vaccine compositions of the present invention preferably comprise a minimum of 4 and a maximum of 6 strains representing a single clade each, and the at least two PspAs are optionally serologically or broadly cross-reactive.
    Type: Application
    Filed: September 30, 2003
    Publication date: April 8, 2004
    Inventors: Robert S. Becker, David E. Briles, Susan Hollingshead
  • Patent number: 6638516
    Abstract: The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned sequences of a C-terminal region of an alpha helical region of PspA. Additionally, the families are further comprised of clades, wherein PspAs from strains which belong to a clade exhibit at least 75% sequence homology in aligned sequences of the C-terminal region of the alpha helix of PspA. Vaccine compositions of the present invention preferably comprise a minimum of 4 and a maximum of 6 strains representing a single clade each, and the at least two PspAs are optionally serologically or broadly cross-reactive.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: October 28, 2003
    Assignee: The UAB Research Foundation
    Inventors: Robert S. Becker, David E. Briles, Susan Hollingshead
  • Patent number: 6592876
    Abstract: PspAs, portions thereof, DNA therefor, and immunological compositions, primers and probes based thereon are disclosed claimed.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: July 15, 2003
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Larry S. McDaniel, Edwin Swiatlo, Janet Yother, Alexis Brooks-Walter
  • Publication number: 20030059438
    Abstract: Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g.
    Type: Application
    Filed: April 23, 1999
    Publication date: March 27, 2003
    Applicant: NIXON PEABODY LLP
    Inventors: DAVID E. BRILES, SUSAN K. HOLLINGSHEAD, ALEXIS BROOKS-WALTER
  • Patent number: 6500613
    Abstract: The present invention relates to pneumococcal genes, portions thereof, expression products therefrom and uses of such genes, portions and products; especially to genes of Streptococcus pneumoniae, e.g., the gene encoding pneumococcal surface protein A (PspA), i.e., the pspA gene, the gene encoding pneumococcal surface protein A-like proteins, such as pspA-like genes, e.g., the gene encoding pneumococcal surface protein C (PspC), i.e., the pspC gene, portions of such genes, expression products therefrom, and the uses of such genes, portions thereof and expression products therefrom.
    Type: Grant
    Filed: September 16, 1996
    Date of Patent: December 31, 2002
    Assignee: University of Alabama at Birmingham
    Inventors: David E. Briles, Larry S. McDaniel, Edwin Swiatlo, Janet Yother, Marilyn J. Crain, Susan Hollingshead, Rebecca Tart, Alexis Brooks-Walter