Patents by Inventor David E. Clapham
David E. Clapham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200209259Abstract: Methods for identifying compounds that modulate polycystin-1/polycystin-2 (PKD1/PKD2) ion channel activity or cilium/plasma membrane trafficking are provided. Related reagents and uses of the compounds are also provided.Type: ApplicationFiled: March 8, 2017Publication date: July 2, 2020Applicant: Children's Medical Center CorporationInventors: Markus G. Delling, David E. Clapham, Julia F. Doerner
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Publication number: 20130289520Abstract: The present invention provides methods and compositions for highly precise spatial and temporal control over cytosolic delivery of compounds, in particular, those compounds that would otherwise be cell-impermeable. Among other things, the present invention provides a composition for targeted drug delivery comprising a nanoparticle, a targeting moiety specific for a cell type of interest, a light-activated drug delivery system, wherein the nanoparticles are associated with the targeting moiety and the light-activated drug delivery system.Type: ApplicationFiled: April 22, 2011Publication date: October 31, 2013Applicants: CHILDREN'S HOSPITAL BOSTON, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Sebastien Febvay, Davide Maurizio Marini, David E. Clapham
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Publication number: 20130102495Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.Type: ApplicationFiled: May 30, 2012Publication date: April 25, 2013Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: David E. CLAPHAM, Dejian REN
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Publication number: 20130072403Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.Type: ApplicationFiled: January 30, 2012Publication date: March 21, 2013Applicant: Children's Medical Center CorporationInventors: Magdalene M. Moran, Jayhong A. Chong, Ian Scott Ramsey, David E. Clapham
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Publication number: 20130067603Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.Type: ApplicationFiled: February 10, 2012Publication date: March 14, 2013Inventors: Magdalene M. Moran, Jayhong A. Chong, Ian Scott Ramsey, David E. Clapham
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Patent number: 8211666Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.Type: GrantFiled: October 30, 2003Date of Patent: July 3, 2012Assignee: Children's Medical Center CorporationInventors: David E. Clapham, Dejian Ren
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Patent number: 8110668Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.Type: GrantFiled: August 4, 2003Date of Patent: February 7, 2012Assignee: Children's Medical Center CorporationInventors: Magdalene M. Moran, Jayhong A. Chong, Ian Scott Ramsey, David E. Clapham
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Publication number: 20090249499Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.Type: ApplicationFiled: October 2, 2008Publication date: October 1, 2009Inventors: Magdalene M. Moran, Jayhong A. Chong, Ian Scott Ramsey, David E. Clapham
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Publication number: 20080311578Abstract: The present invention provides methods and compositions for expressing eukaryotic membrane proteins.Type: ApplicationFiled: January 15, 2008Publication date: December 18, 2008Applicant: Hydra Biosciences, Inc.Inventors: Jayhong A. Chong, Magdalene M. Moran, David E. Clapham
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Patent number: 7339029Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.Type: GrantFiled: April 21, 2004Date of Patent: March 4, 2008Assignee: Children's Medical Center CorporationInventors: Deijan Ren, David E. Clapham, David L. Garbers, Timothy A. Quill
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Publication number: 20040157292Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.Type: ApplicationFiled: October 30, 2003Publication date: August 12, 2004Applicant: Children's Medical CenterInventors: David E. Clapham, Dejian Ren
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Patent number: 5260578Abstract: A scanning confocal microscope (50) capable of providing ultraviolet (UV) excitation. The optical train substantially corrects scanning and focusing errors over the wavelength range that includes UV and visible wavelengths. In a particular embodiment, the lenses (27, 30') in the common path portion of the optical train are corrected for chromatically induced scanning errors while extra lenses (60, 65) are provided in the forward UV path to correct for focusing errors due to longitudinal chromatic (visible/UV) aberration.Type: GrantFiled: April 30, 1992Date of Patent: November 9, 1993Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allison C. Bliton, David E. Clapham, James D. Lechleiter