Patents by Inventor David E. Edgren

David E. Edgren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prolonged release active agent dosage form adapted for gastric retention
    Patent number: 6120803
    Abstract: The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
    Type: Grant
    Filed: August 10, 1998
    Date of Patent: September 19, 2000
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Liang-Chang Dong, David E. Edgren, Felix Theeuwes, Phyllis I. Gardner, Francisco Jao, Jason J. Wan
  • Active agent dosage form comprising a matrix and at least two insoluble bands
    Patent number: 5534263
    Abstract: The present invention is directed to an active agent dosage form which is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has on its surface two or more insoluble bands. The invention is also directed to the method for making the active agent dosage form.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: July 9, 1996
    Assignee: Alza Corporation
    Inventors: Patrick S.-L. Wong, David E. Edgren, Liang C. Dong, Vincent J. Ferrari
  • Stereoisomer therapy
    Patent number: 5338550
    Abstract: A dosage form is disclosed comprising a first layer and a second layer. The first layer provides immediate therapy and comprises a drug stereoisomer and the second layer provides prolonged therapy and comprises a drug racemate.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: August 16, 1994
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Gurdish K. Bhatti, Judy A. Magruder
  • Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
    Patent number: 5221536
    Abstract: A dosage form is disclosed comprising an anti-Parkinson's disease drug for administering to a patient in need of anti-Parkinson's disease therapy.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: June 22, 1993
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Howard A. Carpenter, Gurdish K. Bhatti, Atul D. Ayer
  • Dosage form providing immediate therapy followed by prolonged therapy
    Patent number: 5204116
    Abstract: A dosage form is disclosed comprising a first layer and a second layer. The first layer provides immediate therapy and comprises a drug stereoisomer and the second layer provides prolonged therapy and comprises a drug racemate.
    Type: Grant
    Filed: May 1, 1991
    Date of Patent: April 20, 1993
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Gurdish K. Bhatti, Judy A. Magruder
  • Oral osmotic device
    Patent number: 5200194
    Abstract: An osmotic device (10) for delivering a beneficial drug, such as an anti-microbial drug, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a thin semipermeable membrane wall (12) surrounding a compartment (13) housing a beneficial agent (14) that has at least some degree of solubility in aqueous biological fluids, e.g., saliva, and a fibrous support material (15) composed of hydrophilic water-insoluble fibers. A passageway (17) in the wall (12) connects the agent 14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the fibrous support material (15).
    Type: Grant
    Filed: December 18, 1991
    Date of Patent: April 6, 1993
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Gurdish K. Bhatti
  • Dosage form for treating central nervous system disorders
    Patent number: 5192550
    Abstract: A dosage form is disclosed comprising an anti-Parkinson's disease drug for administering to a patient in need of anti-Parkinson's disease therapy.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: March 9, 1993
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Howard A. Carpenter, Gurdish K. Bhatti, Atul D. Ayer
  • Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
    Patent number: 5190763
    Abstract: A dosage form is disclosed comprising an anti-Parkinson's disease drug for administering to a patient in need of anti-Parkinson's disease therapy.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: March 2, 1993
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Howard A. Carpenter, Gurdish K. Bhatti, Atul D. Ayer
  • Annealed composition for pharmaceutically acceptable drug
    Patent number: 5160743
    Abstract: A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: November 3, 1992
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Felix Theeuwes
  • Dosage form for Parkinson's disease, spasticity and muscle spasms
    Patent number: 5128145
    Abstract: A dosage form is disclosed comprising a drug and a maltodextrin polymer for administering to a patient a drug in need of therapy.
    Type: Grant
    Filed: August 2, 1991
    Date of Patent: July 7, 1992
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Gurdish K. Bhatti, Howard A. Carpenter
  • Dosage form comprising drug and maltodextrin
    Patent number: 5057321
    Abstract: A dosage form is disclosed comprising a drug and a maltodextrin polymer for administering to a patient a drug in need of therapy.
    Type: Grant
    Filed: June 13, 1990
    Date of Patent: October 15, 1991
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Gurdish K. Bhatti, Howard A. Carpenter
  • Annealed coats
    Patent number: 5024842
    Abstract: A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.
    Type: Grant
    Filed: April 2, 1990
    Date of Patent: June 18, 1991
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Felix Theeuwes
  • Delivery system
    Patent number: 5006346
    Abstract: A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.
    Type: Grant
    Filed: May 11, 1989
    Date of Patent: April 9, 1991
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Felix Theeuwes
  • Cellulosic dosage form
    Patent number: 4946685
    Abstract: A bilaminate dosage form is disclosed comprising a first lamina and a second lamina with each lamina comprising a cellulose ether composition, and wherein a drug is present in at least one of the lamina. An optional coat is disclosed that surrounds the bilaminate form.
    Type: Grant
    Filed: September 1, 1988
    Date of Patent: August 7, 1990
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Judy A. Magruder, Gurdish K. Bhatti
  • Aqueous based pharmaceutical coating composition for dosage forms
    Patent number: 4931285
    Abstract: A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.
    Type: Grant
    Filed: April 28, 1988
    Date of Patent: June 5, 1990
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Felix Theeuwes
  • Dosage form for delivering acetaminophen or phenylpropanolamine
    Patent number: 4915953
    Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: April 10, 1990
    Assignee: ALZA Corporation
    Inventors: Maureen L. Jordan, Atul D. Ayer, Paul R. Magruder, David E. Edgren
  • Dosage form for delivering a drug at two different rates
    Patent number: 4915954
    Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: April 10, 1990
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, Maureen L. Jordan, Paul R. Magruder, David E. Edgren
  • Controlled release dosage form comprising different cellulose ethers
    Patent number: 4871548
    Abstract: A dosage form is disclosed comprising a low number average molecular weight hydroxypropylmethylcellulose, a high number average molecular weight hydroxypropylmethylcellulose, and a beneficial drug.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: October 3, 1989
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Judy A. Magruder, Gurdish K. Bhatti
  • Dosage form comprising fast agent delivery followed by slow agent delivery
    Patent number: 4814181
    Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: March 21, 1989
    Assignee: ALZA Corporation
    Inventors: Maureen L. Jordan, Atul D. Ayer, Paul R. Magruder, David E. Edgren
  • Dosage form comprising parallel lamine
    Patent number: 4786503
    Abstract: A bilaminated dosage form is disclosed comprising at least 30 weight percent cellulose ether, a first lamina and a second lamina with each lamina comprising a different cellulose ether formulation, and a drug in at least one of the lamina.
    Type: Grant
    Filed: April 6, 1987
    Date of Patent: November 22, 1988
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Judy A. Magruder, Gurdish K. Bhatti